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116 (0,083s) •

Project

Microenvironment of malignant melanoma as a factor of tumor aggressiveness (GA16-05534S)

Cancer microenvironment is a very important factor participating in the control of biological properties of many types of malignant tumors. Our previous research demonstrated that various cell types such as cancer-associated fibroblasts on t...

EA - Morfologické obory a cytologie

  • 2016 - 2018
    • •
  • 9 848 tis. Kč
    • •
  • 8 801 tis. Kč
    • •
  • GA ČR
Project

Mechanical Regulation of Mitochondria Function and Glycolysis in Liver Cancer Cells (GA22-18634S)

The stiffness of the cellular microenvironment represents a crucial mechanical activity to variable stiffness of the microenvironment. Concerning liver cancer cells, knowledge in current literature, on how the stiffness of micro...

Cell biology

  • 2022 - 2024
    • •
  • 8 706 tis. Kč
    • •
  • 8 378 tis. Kč
    • •
  • GA ČR
Project

Bone marrow microenvironment analysis in extramedullary relapse of multiple myeloma (NV17-29343A)

independence from the bone marrow microenvironment. This grant aims to clarify factors coupled with independence of these cells from the bone marrow microenvironment and the role of the MM tumor microenvironment in this pr...

FD - Onkologie a hematologie

  • 2017 - 2021
    • •
  • 9 864 tis. Kč
    • •
  • 9 823 tis. Kč
    • •
  • MZ
Project

Complex assessment of microenvironment and its impact on clinical course of chronic lymphocytic leukemia. (NT13412)

1. Assessment of selected markers of microenvironment in CLL: membrane antigens (CD49d, CD31, CD105, CD54), circulating plasma proteins (sCD105, angiopoietin-2, endostatin, thrombospondin-1, TGF-beta1), genes affecting angiogenesis (FGF-2, C...

FD - Onkologie a hematologie

  • 2012 - 2015
    • •
  • 3 024 tis. Kč
    • •
  • 3 024 tis. Kč
    • •
  • MZ
Project

Biology and therapeutic significance of leukemic cells and their interaction with the bone marrow microenvironment (NS10473)

on their microenvironment, as proved by their typical localization in the bone marrow, thus we intend feeder layer that mimics in vitro the microenvironment of the bone marrow.......

FD - Onkologie a hematologie

  • 2009 - 2011
    • •
  • 7 714 tis. Kč
    • •
  • 7 714 tis. Kč
    • •
  • MZ
Project

THE EFFECT OF HPMA DRUG BASED THERAPY ON THE LOCAL TUMOR MICROENVIRONMENT (IAA400200702)

of tumor microenvironment could help us to design a new polymeric conjugates...

CD - Makromolekulární chemie

  • 2007 - 2011
    • •
  • 5 878 tis. Kč
    • •
  • 5 878 tis. Kč
    • •
  • AV ČR
Project

Analysis of stromal microenvironment, molecular and immunohistochemical aspects of malignant melanoma. (NV16-30954A)

of stromal microenvironment. Selected mutations will be functionally tested in culture...

EA - Morfologické obory a cytologie

  • 2016 - 2019
    • •
  • 13 678 tis. Kč
    • •
  • 13 678 tis. Kč
    • •
  • MZ
Project

Coupled chemo-mechanical model of normal and cancer microenvironment (GA23-04974S)

microenvironment regulate epithelial morphogenesis and tumorigenesis using an iterative will contribute a missing coupled chemo-mechanical model of tissue microenvironment......

Applied mechanics

  • 2023 - 2025
    • •
  • 8 170 tis. Kč
    • •
  • 8 139 tis. Kč
    • •
  • GA ČR
Project

Effect of cell stiffness and microenvironment as a therapy response predictor in head and neck cancer (GA18-03978S)

This project represents step to personalized medicine in therapy of head and neck squamous cell carcinoma (HNSCC). We will focus on evaluation of effect of tumour microenvironment (TME) during chemotherapeutic treatment. Our study will revea...

Otorhinolaryngology

  • 2018 - 2022
    • •
  • 10 243 tis. Kč
    • •
  • 9 693 tis. Kč
    • •
  • GA ČR
Project

The role of stem cells and factors of epithelial-mesenchymal transition in cancer stromal microenvironment alteration (GAP304/10/1070)

microenvironment might help todevelop new strategies for tumor treatment based on an impact...

FD - Onkologie a hematologie

  • 2010 - 2012
    • •
  • 2 497 tis. Kč
    • •
  • 2 497 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 116