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9 (0,055s) •

Project

Astrocyte-microglia communication as a target for stroke therapy (GA23-05327S)

- and space- dependent manner. Astrocytes and microglia represent key components in the stroke pathobiology. To characterize astrocyte-microglia interaction network during by astrocytes and microglia in ischemic mouse brain...

Neurosciences (including psychophysiology)

  • 2023 - 2025
    • •
  • 10 874 tis. Kč
    • •
  • 10 874 tis. Kč
    • •
  • GA ČR
Project

Prioritization of pathways linking aging and Alzheimer’s disease to cognitive decline and dementia (9F24001)

1. Develop a procedure to differentiate human embryonic stem cells (iPSCs) into microglia. 2. Use this model to test the hypotheses that will be formulated based on the results from the "omics" analyses proposed in the next work packages (W...

Other clinical medicine subjects

  • 2024 - 2027
    • •
  • 7 083 tis. Kč
    • •
  • 7 083 tis. Kč
    • •
  • MŠMT
Project

The role of retroviral proteins in brain dysfunction animal model of the schizophrenia (NR8797)

preferentially oriented to microglia dysfunction....

FH - Neurologie, neurochirurgie, neurovědy

  • 2006 - 2009
    • •
  • 11 258 tis. Kč
    • •
  • 11 121 tis. Kč
    • •
  • MZ
Project

The role of glial cells during ischemia/reperfusion and in the course of nervous tissue regeneration. (GA305/06/1316)

glutamate and purinergic receptors, in astrocytes, microglia and NG2 proteoglycan expressing glia. Ca2+ entry perturbations will be correlated with the onset of microglia......

FH - Neurologie, neurochirurgie, neurovědy

  • 2006 - 2008
    • •
  • 3 148 tis. Kč
    • •
  • 3 148 tis. Kč
    • •
  • GA ČR
Project

Glial cells- the key players in the progression of amyotrophic lateral sclerosis (GA19-02046S)

A striking functional heterogeneity exists within astrocytes, NG2-glia, oligodendrocytes and microglia. It is presented in various subpopulations that are characterized by distinct gene expression profiles, functional properties and their po...

Neurosciences (including psychophysiology)

  • 2019 - 2023
    • •
  • 9 950 tis. Kč
    • •
  • 9 734 tis. Kč
    • •
  • GA ČR
Project

Mechanisms of neuronal injury during tick-borne encephalitis virus infection of the CNS. (GA14-29256S)

, microglia and brain microvascular epithelial cells). We propose that the innate immune...

EE - Mikrobiologie, virologie

  • 2014 - 2016
    • •
  • 7 506 tis. Kč
    • •
  • 7 506 tis. Kč
    • •
  • GA ČR
Project

The influence of immune system dysregulation and latent toxoplasmosis on brain morphology in schizophrenia animal models and a prospective volumetric study in patients (NT13843)

, neurodegeneration and microglia activation will be evaluated at PD 90. The human part...

FL - Psychiatrie, sexuologie

  • 2012 - 2015
    • •
  • 8 950 tis. Kč
    • •
  • 8 950 tis. Kč
    • •
  • MZ
Project

Neurovascular unit cells interactions leading to the blood-brain barrier breakdown during tick-borne encephalitis (GA20-30500S)

, pericytes, microglia and endothelial cells) and their interactions within...

Virology

  • 2020 - 2022
    • •
  • 8 098 tis. Kč
    • •
  • 8 098 tis. Kč
    • •
  • GA ČR
Project

Kynurenines and their role in the inflammatory response and pathophysiology of cerebral vasospasms following the aneurysmal subarachnoid hemorrhage (NW25-04-00246)

cells, including microglia and astrocytes, as well as the recruitment of peripheral...

Neurosciences (including psychophysiology)

  • 2025 - 2028
    • •
  • 13 891 tis. Kč
    • •
  • 13 891 tis. Kč
    • •
  • MZ
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