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404 (0,086s) •

Project

The development of new microsatellite instability diagnostic tests for therapeutic and prognostic purposes in oncology (TH04010095)

The aim is to develop new tests for microsatellite instability (MSI) diagnostics in oncology using the NGS and to offer an accurate tool for clinicians for diagnostics and use of target therapy treatment. A test for differential dia...

Technologies involving identifying the functioning of DNA, proteins and enzymes and how they influence the onset of disease and maintenance of well-being (gene-based diagnostics and therapeutic interventions [pharmacogenomics, gene-based therapeutics])

  • 2019 - 2022
    • •
  • 14 581 tis. Kč
    • •
  • 8 533 tis. Kč
    • •
  • TA ČR
Project

Microsatellite Instability and Loss of Heterozygosity of Specific Genes in Hematological Malignancies. (IZ3567)

FD - Onkologie a hematologie

  • 1996 - 1998
    • •
  • 1 764 tis. Kč
    • •
  • 1 764 tis. Kč
    • •
  • MZ
Project

Clinical and pothogenetic aspects of telomerase activity in colorectal and breast cancer with respect to their sporadic versus hereditary occurence (NC6741)

, microsatellite, and chromosomal instability, histopathological characteristics...

FD - Onkologie a hematologie

  • 2001 - 2003
    • •
  • 2 544 tis. Kč
    • •
  • 2 502 tis. Kč
    • •
  • MZ
Project

Evolution of genomic instability and disruption of telomere integrity in colorectal cancer (NU22J-03-00028)

on the characteristics of genomic instability. Chromosomal instability (CIN) is the most frequent form of genomic instability while microsatellite instability (MSI) is observed integrity in relation to ge...

Oncology

  • 2022 - 2025
    • •
  • 5 828 tis. Kč
    • •
  • 5 828 tis. Kč
    • •
  • MZ
Project

Etiopathogenetic role and prognostic significance of PAX 2 and PAX 8 expression and microsatelite instability on chromosome 3 and 9 in renal cell carcinoma (NC7519)

The goal of the study is to evaluate tho pathogenetic and prognostic role of expression of genes PAX 2 and PAX 8 and microsatellite on chromosomes 3 and 9 in renal cell carcinoma tissue. Results will be correlated with the histological type ...

FD - Onkologie a hematologie

  • 2003 - 2005
    • •
  • 2 185 tis. Kč
    • •
  • 2 185 tis. Kč
    • •
  • MZ
Project

The expression of PAX5 gene in transitional cell bladder cancer.Its prognostic role and comparing with p53 pathology and chromosome 9 microsalellite instability. (NC5961)

Prospective study evaluated PAX5 expression in the transitional cell bladder cancer,correlation with the p53 pathology and chromosome 9 microsatelite instabillity,prognostic role evaluation.......

FD - Onkologie a hematologie

  • 2000 - 2002
    • •
  • 1 942 tis. Kč
    • •
  • 1 942 tis. Kč
    • •
  • MZ
Project

Detection of mutation in MLH1, MSH2 and APC genes in the sporadic colorectal adenomas (NK7270)

Immunohistochemistry is a new method for detection of the loss of expression of MLH1, MSH2 and APC genes. The aim of the study is to determine the frequency of mutations in the genes mentioned above in soradic colorectal adenomas using this technique...

FE - Ostatní obory vnitřního lékařství

  • 2002 - 2004
    • •
  • 1 445 tis. Kč
    • •
  • 1 426 tis. Kč
    • •
  • MZ
Project

Comprehensive analysis of ovarian sex cord-stromal tumors (NU21-03-00238)

, including microsatellite instability and tumor microenviroment, is still limited due...

Pathology

  • 2021 - 2024
    • •
  • 11 825 tis. Kč
    • •
  • 11 825 tis. Kč
    • •
  • MZ
Project

The study of genetic variability and stability of long term cultures of Norway spruce somatic embryos (GP521/03/P148)

of somaticembryos derived from trees from different stands AFLP and microsatellite analysis duringlong term in vitro cultivation AFLP and microsatellite analysis will be used five years. Within this old samples no genetic insta...

EB - Genetika a molekulární biologie

  • 2003 - 2005
    • •
  • 690 tis. Kč
    • •
  • 690 tis. Kč
    • •
  • GA ČR
Project

Computer analysis of microsatellite expansion in the human genome. (GA302/97/0313)

Eucaryotic genomes contain hundreds of thousands of microsatellite sequences answers tothe following questions:(i)Do all microsatellites expand or are there non-expanding microsatellites in the eucaryotic genomes?(ii)Does t...

EB - Genetika a molekulární biologie

  • 1997 - 1998
    • •
  • 1 046 tis. Kč
    • •
  • 821 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 404