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109 (0,156s) •

Project

Radio-frequency characterization of microtubules using micro- and nanosensors (GA15-17102S)

extremely intriguing and biologically omnipresent nanostructures - microtubules of microtubule will be identified based on the orthotropic elastic shell model combined with optimized coarse-grained atomic model of a microtubule...

JA - Elektronika a optoelektronika, elektrotechnika

  • 2015 - 2017
    • •
  • 4 921 tis. Kč
    • •
  • 4 921 tis. Kč
    • •
  • GA ČR
Project

Microtubule-binding function of plant HSP90/82 protein (ME10111)

The goal of the project is to define the role of HSP90/82 associated with its microtubule- and membrane-binding functions in plant cells. Further, using unique biochemical methods, new proteins binding both microtubules and membrane...

EB - Genetika a molekulární biologie

  • 2010 - 2012
    • •
  • 1 650 tis. Kč
    • •
  • 1 650 tis. Kč
    • •
  • MŠMT
Project

Calcium signaling to microtubules in activated mast cells (GA16-25159S)

-dependent protrusions containing microtubules. However, corresponding signaling pathway protein kinases cPKC and MLCK are important for such microtubule reorganization. In this project we will evaluate our hypothesis that cPKC and ...

EA - Morfologické obory a cytologie

  • 2016 - 2018
    • •
  • 6 075 tis. Kč
    • •
  • 5 781 tis. Kč
    • •
  • GA ČR
Project

Role of protein phosphatases in regulation of microtubule organization in mast cells (GA16-23702S)

The activation of mast cells leads to rapid reorganization of microtubules and release of inflammatory mediators. The mechanisms underlying microtubule formation are largely unknown. We have previously shown that γ-tubulin, key regu...

EC - Imunologie

  • 2016 - 2018
    • •
  • 5 458 tis. Kč
    • •
  • 5 400 tis. Kč
    • •
  • GA ČR
Project

Regulation of microtubule formation in brain cancer cells (LH12050)

regulating microtubules in glioblastoma cell lines and gliomas 3. To characterize of microtubule regulatory proteins in glioblastoma cell proliferation and motility Better understanding of microtubule functions in gliomas ...

EA - Morfologické obory a cytologie

  • 2012 - 2015
    • •
  • 3 432 tis. Kč
    • •
  • 3 272 tis. Kč
    • •
  • MŠMT
Project

Microtubules in activated mast cells - targets for innovative therapies (LD13015)

The aims othis project are: 1. To identify composition and function of complexes containing tubulins and signalling molecules in activated mast cells. 2. To characterize gamma-tubulin interactions with phosphoinositide-3-kinase and Src family kinases...

EC - Imunologie

  • 2013 - 2014
    • •
  • 942 tis. Kč
    • •
  • 942 tis. Kč
    • •
  • MŠMT
Project

Regulation of microtubule organization by ufmylation ligase complex and C53 signaling protein (GA19-20716S)

While a role of γ-tubulin complexes in microtubule nucleation is well that modulates microtubule nucleation and stabilizes C53. ER-mitochondria-associated membranes play important role in cellular signaling and microtubules...

Cell biology

  • 2019 - 2021
    • •
  • 7 692 tis. Kč
    • •
  • 7 203 tis. Kč
    • •
  • GA ČR
Project

Megahertz Imaging of Microtubule Dynamics by Interferometric Scattering Microscopy (GA22-11753S)

Microtubules are cytoskeletal polymers composed of tubulin subunits and disassembly. During microtubule disassembly, electron micrographs suggest structural microtubules. However, these transitions of the structure have nev...

Optics (including laser optics and quantum optics)

  • 2022 - 2024
    • •
  • 9 534 tis. Kč
    • •
  • 9 534 tis. Kč
    • •
  • GA ČR
Project

Study of the role of gamma-tubulin complexes in high plant acentrosomal cells by in vitro polymerization of tubulin (GP204/02/D068)

Microtubules are polar polymers organized from defined microtubule organizing MTOCs. g-Tubulin is ubiqitous MTOC component important in microtubule nucleation polymerization developed in our previous grant. Association of g...

EA - Morfologické obory a cytologie

  • 2002 - 2005
    • •
  • 3 366 tis. Kč
    • •
  • 747 tis. Kč
    • •
  • GA ČR
Project

Role of GIT-PIX signaling complex in regulation of microtubule nucleation in mast cells (GA15-22194S)

Gamma-tubulin is essential for nucleation of microtubules. While the role of γ-tubulin ring complexes as microtubule nucleators is well established, regulation of γ-PAK signaling pathway in the regulation of microtubule org...

EA - Morfologické obory a cytologie

  • 2015 - 2017
    • •
  • 5 725 tis. Kč
    • •
  • 5 725 tis. Kč
    • •
  • GA ČR
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