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Projects

23 projects (0,204s) •

Project

Circulating microRNAs as non-invasive markers of graft rejection in patients after heart transplantation (NV16-30537A)

Using expression profiling arrays we will identify intracellular (from endomyocardial biopsies) as well as circulating (from plasma, urine and peripheral blood mononuclear cells) miRNAs that will distinguish heart transplant patients with graft rejec...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2016 - 2020
    • •
  • 15 167 tis. Kč
    • •
  • 14 149 tis. Kč
    • •
  • MZ
Project

Molecularly guided radiotherapy or radiochemotherapy based on mikroRNA profile in head and neck cancer patients- a feasibility study. (NV15-31627A)

Radiotherapy is one of the cornerstones of head and neck cancer treatment. Intensification of treatment is improving therapeutic outcomes, but these are still not satisfactory. In our work we address the usage of microRNAs in connection with curative...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 11 546 tis. Kč
    • •
  • 9 929 tis. Kč
    • •
  • MZ
Project

Bone marrow microenvironment analysis in extramedullary relapse of multiple myeloma (NV17-29343A)

Extramedullary relapse (EM) of multiple myeloma is becoming another obstacle on the way towards improvement of quality of life of multiple myeloma (MM) patients. EM is characterized by aggressive disease course and shorter survival. EM is caused by t...

FD - Onkologie a hematologie

  • 2017 - 2021
    • •
  • 9 864 tis. Kč
    • •
  • 9 823 tis. Kč
    • •
  • MZ
Project

Human urinary exosomes - the source of new biomarkers for the diagnosis and follow-up of kidney diseases (NV15-31662A)

The project will study new diagnostic and predictive biomarkers in urinary exosomes in patients with immune-based kidney diseases (lupus nephrititis and ANCA-associated vasculitis) and IgA nephropathy, Urinary exosomes contain proteins and nucleic ac...

FE - Ostatní obory vnitřního lékařství

  • 2015 - 2019
    • •
  • 7 500 tis. Kč
    • •
  • 7 441 tis. Kč
    • •
  • MZ
Project

Using MALDI-TOF mass spectrometry for identification of molecular patterns in relapsed multiple myeloma patients (NU21-03-00076)

Multiple myeloma is the second most common hematological malignancy of the elderly. Median age at diagnosis is 65. Bone marrow transplants as well as new drugs (immunomodulatory drugs, proteasome inhibitors and monoclonal antibodies) significantly in...

Hematology

  • 2021 - 2024
    • •
  • 10 746 tis. Kč
    • •
  • 10 746 tis. Kč
    • •
  • MZ
Project

Usage of cerebrospinal fluid microRNAs in diagnosis of brain tumors (NV15-34553A)

Gliomas constitute a morphologically and prognostically diverse group of neoplasms that accounts for more than 60% of primary brain tumors. Similarly, therapy also differs among particular grades of gliomas and, thus, its indication depends on accura...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 5 924 tis. Kč
    • •
  • 5 924 tis. Kč
    • •
  • MZ
Project

Utility of tissue/circulating microRNAs for response prediction and improvement of restaging accuracy in rectal cancer after neoadjuvant treatment (NV16-31765A)

Alteration of the microRNA regulatory network is one of the key events in pathogenesis of wide range of malignancies including rectal cancer. MicroRNAs are abundant and could be determined not only in tumor tissue, but also in blood plasma, where the...

FD - Onkologie a hematologie

  • 2016 - 2019
    • •
  • 14 599 tis. Kč
    • •
  • 14 599 tis. Kč
    • •
  • MZ
Project

Usage of circulating microRNAs for the diagnosis of pancreatic cancer and identification of patients who will not benefit from the surgical resection (NV16-31314A)

Pancreatic ductal adenocarcinoma is one of the most malignant types of cancer. The main reasons of high mortality are late diagnosis and low effectiveness of conventional radiotherapy and chemotherapy. Therefore, the radical surgical resection togeth...

FD - Onkologie a hematologie

  • 2016 - 2019
    • •
  • 12 425 tis. Kč
    • •
  • 12 167 tis. Kč
    • •
  • MZ
Project

Prognostic and predictive molecular factors in patients with metastatic renal cell carcinoma treated with tyrosine kinase inhibitors (NV15-34678A)

The main cause of morbidity and mortality of patients with renal cell carcinoma is the progression to metastatic disease (mRCC). Identification and validation of biomarkers has the potential to improve the therapeutic results in mRCC treated with tyr...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 9 007 tis. Kč
    • •
  • 8 747 tis. Kč
    • •
  • MZ
Project

Application of high-throughput technologies for screening of plasma circulating microRNAs in myelodysplastic syndromes (NV16-33617A)

Circulating microRNAs (miRNAs) are new promising semi-invasive molecular markers of various types of cancer. However, little information is known about their deregulation in myelodysplastic syndromes (MDS). Nowadays, the diagnosis of MDS is based on ...

FD - Onkologie a hematologie

  • 2016 - 2019
    • •
  • 7 861 tis. Kč
    • •
  • 7 861 tis. Kč
    • •
  • MZ
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