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25 (0,088s) •

Project

Circulating microRNAs as non-invasive markers of graft rejection in patients after heart transplantation (NV16-30537A)

Using expression profiling arrays we will identify intracellular (from endomyocardial biopsies) as well as circulating (from plasma, urine and peripheral blood mononuclear cells) miRNAs that will distinguish heart transplant patients with graft rejec...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2016 - 2020
    • •
  • 15 167 tis. Kč
    • •
  • 14 149 tis. Kč
    • •
  • MZ
Project

Molecularly guided radiotherapy or radiochemotherapy based on mikroRNA profile in head and neck cancer patients- a feasibility study. (NV15-31627A)

Radiotherapy is one of the cornerstones of head and neck cancer treatment. Intensification of treatment is improving therapeutic outcomes, but these are still not satisfactory. In our work we address the usage of microRNAs in connection with curative...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 11 546 tis. Kč
    • •
  • 9 929 tis. Kč
    • •
  • MZ
Project

Bone marrow microenvironment analysis in extramedullary relapse of multiple myeloma (NV17-29343A)

Extramedullary relapse (EM) of multiple myeloma is becoming another obstacle on the way towards improvement of quality of life of multiple myeloma (MM) patients. EM is characterized by aggressive disease course and shorter survival. EM is caused by t...

FD - Onkologie a hematologie

  • 2017 - 2021
    • •
  • 9 864 tis. Kč
    • •
  • 9 823 tis. Kč
    • •
  • MZ
Project

Human urinary exosomes - the source of new biomarkers for the diagnosis and follow-up of kidney diseases (NV15-31662A)

The project will study new diagnostic and predictive biomarkers in urinary exosomes in patients with immune-based kidney diseases (lupus nephrititis and ANCA-associated vasculitis) and IgA nephropathy, Urinary exosomes contain proteins and nucleic ac...

FE - Ostatní obory vnitřního lékařství

  • 2015 - 2019
    • •
  • 7 500 tis. Kč
    • •
  • 7 441 tis. Kč
    • •
  • MZ
Project

Using MALDI-TOF mass spectrometry for identification of molecular patterns in relapsed multiple myeloma patients (NU21-03-00076)

Multiple myeloma is the second most common hematological malignancy of the elderly. Median age at diagnosis is 65. Bone marrow transplants as well as new drugs (immunomodulatory drugs, proteasome inhibitors and monoclonal antibodies) significantly in...

Hematology

  • 2021 - 2024
    • •
  • 10 729 tis. Kč
    • •
  • 10 729 tis. Kč
    • •
  • MZ
Project

Finding new diagnostic and therapeutic targets in cartilaginous tumours (NW25-10-00260)

Chondrosarcoma is the second most common primary bone sarcoma and the tumor cells produce cartilage matrix. It is characterized by slow growth, with a tendency to metastasize especially into the lungs. High histological grade and axial location are a...

Orthopaedics

  • 2025 - 2028
    • •
  • 12 397 tis. Kč
    • •
  • 12 397 tis. Kč
    • •
  • MZ
Project

Utility of tissue/circulating microRNAs for response prediction and improvement of restaging accuracy in rectal cancer after neoadjuvant treatment (NV16-31765A)

Alteration of the microRNA regulatory network is one of the key events in pathogenesis of wide range of malignancies including rectal cancer. MicroRNAs are abundant and could be determined not only in tumor tissue, but also in blood plasma, where the...

FD - Onkologie a hematologie

  • 2016 - 2019
    • •
  • 14 599 tis. Kč
    • •
  • 14 599 tis. Kč
    • •
  • MZ
Project

Usage of cerebrospinal fluid microRNAs in diagnosis of brain tumors (NV15-34553A)

Gliomas constitute a morphologically and prognostically diverse group of neoplasms that accounts for more than 60% of primary brain tumors. Similarly, therapy also differs among particular grades of gliomas and, thus, its indication depends on accura...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 5 924 tis. Kč
    • •
  • 5 924 tis. Kč
    • •
  • MZ
Project

Usage of circulating microRNAs for the diagnosis of pancreatic cancer and identification of patients who will not benefit from the surgical resection (NV16-31314A)

Pancreatic ductal adenocarcinoma is one of the most malignant types of cancer. The main reasons of high mortality are late diagnosis and low effectiveness of conventional radiotherapy and chemotherapy. Therefore, the radical surgical resection togeth...

FD - Onkologie a hematologie

  • 2016 - 2019
    • •
  • 12 425 tis. Kč
    • •
  • 12 167 tis. Kč
    • •
  • MZ
Project

Study of urinary/tissue microRNAs as potential biomarkers of urothelial carcinoma of the urinary bladder (NV15-31071A)

Urothelial carcinoma of the urinary bladder (UCUB) is the most common cancer of the urinary tract. It is the 4th most common cancer in men and the 9th most common in women worldwide characterized by the high rates of recurrence. Current diagnostic me...

FD - Onkologie a hematologie

  • 2015 - 2018
    • •
  • 9 348 tis. Kč
    • •
  • 7 984 tis. Kč
    • •
  • MZ
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