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1 316 (0,204s) •

Project

Mitochondrial energetic metabolism in neonatal period (NT11186)

The development of new noninvasive methods for diagnostics of mitochondrial disorders in minimal amount of samples is crucial for analysis of mitochondrial of mitochondrial disorders in neonates, enable ea...

FG - Pediatrie

  • 2010 - 2014
    • •
  • 9 836 tis. Kč
    • •
  • 9 836 tis. Kč
    • •
  • MZ
Project

New diagnostic algorithms for mitochondrial disorders in children (NT14156)

clinical course of mitochondrial disorders in children of post-newborn periodMitochondrial diseases are characterized by the broad spectrum of clinical symptoms and a very high degree of genetic heterogeneity. This may lea...

FG - Pediatrie

  • 2013 - 2015
    • •
  • 4 830 tis. Kč
    • •
  • 4 830 tis. Kč
    • •
  • MZ
Project

Investigation of cerebrospinal fluid in diagnostics of inborn errors of neurotransmitter metabolism and mitochondrial diseases. (NS10561)

phenotype of patients with confirmed mitochondrial disorder. The part of the project will be analyses of specific proteins in CSF in patients with mitochondrial disorders.The paediatric neurotransmitter disord...

FG - Pediatrie

  • 2009 - 2011
    • •
  • 4 599 tis. Kč
    • •
  • 4 599 tis. Kč
    • •
  • MZ
Project

Mitochondrial disorders with instability of mitochondrial DNA (NV17-30965A)

Mitochondrial disorders (MD) with estimated incidence 1:4000 are caused and mortality. OXPHOS biogenesis is under dual genetic control, mitochondrial DNA (mtDNA will elucidate genetic bases of mitochondrial DNA ins...

EB - Genetika a molekulární biologie

  • 2017 - 2021
    • •
  • 13 003 tis. Kč
    • •
  • 12 960 tis. Kč
    • •
  • MZ
Project

Molecular basis of mitochondrial disorders (GA302/95/1063)

EB - Genetika a molekulární biologie

  • 1995 - 1997
    • •
  • 5 065 tis. Kč
    • •
  • 5 065 tis. Kč
    • •
  • GA ČR
Project

Molecular aspects and biochemical and clinical consequences of maternally inherited mitochondrial disorders (NR8065)

Maternally inherited mitochondrial disorders due to mtDNA mutations represent a heterogeneous group of diseases, which predominantly affect the function of tissues will be studied with demand to improve genetic counceling and preven...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 4 910 tis. Kč
    • •
  • 4 909 tis. Kč
    • •
  • MZ
Project

Study of molecular basis of cytochrome c oxidase deficiency (GP303/03/D132)

Study of mitochondrial disorders on a biochemical and molecular level and analyses of functional impact of these disorders on cells and tissues represent one collaboration between Laboratory for study of mitochondrial

FG - Pediatrie

  • 2003 - 2006
    • •
  • 1 511 tis. Kč
    • •
  • 1 511 tis. Kč
    • •
  • GA ČR
Project

Modulators of mitochondrial enzymes for treatment of neurodegenerative disorders (NV15-28967A)

The mitochondrial enzymes seem to be next target for molecular design in term of Alzheimer Disease (AD) treatment. They are well known for their interaction with ß and cell death. The inhibition of ß-amyloid interaction with mitochondria...

FR - Farmakologie a lékárnická chemie

  • 2015 - 2018
    • •
  • 8 122 tis. Kč
    • •
  • 8 122 tis. Kč
    • •
  • MZ
Project

Mitochondrial dysfunctions in bipolar affective disorder (NV15-28616A)

processes associated or provoking bipolar affective disorder (BD), new diagnostic and questionnaires; selected mitochondrial parameters (citrate synthase and electron transport chain complexes activities, ATP production and mit...

FL - Psychiatrie, sexuologie

  • 2015 - 2018
    • •
  • 7 502 tis. Kč
    • •
  • 7 502 tis. Kč
    • •
  • MZ
Project

Study of natural course of the mitochondrial diseases and new diagnostic approach (NS9782)

To characterize the natural course of the mitochondrial diaseases including differential diagnostic algorithms and to create a tool for measuring life quality of patients suffering from these disorders.......

FG - Pediatrie

  • 2008 - 2011
    • •
  • 2 727 tis. Kč
    • •
  • 2 727 tis. Kč
    • •
  • MZ
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