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1 320 (0,099s) •

Project

Modulators of mitochondrial enzymes for treatment of neurodegenerative disorders (NV15-28967A)

The mitochondrial enzymes seem to be next target for molecular design in term of Alzheimer Disease (AD) treatment. They are well known for their interaction with ß and cell death. The inhibition of ß-amyloid interaction with mit...

FR - Farmakologie a lékárnická chemie

  • 2015 - 2018
    • •
  • 8 122 tis. Kč
    • •
  • 8 122 tis. Kč
    • •
  • MZ
Project

Synthesis of compounds affecting mitochondrial enzymes as potential drugs for Alzheimer disease (LD14009)

of mitochondrial enzymes. These compounds have potential to block interaction of beta-amyloid with mitochondrial enzymes. The novel compounds will be prepared on University of Hradec Kralove studying the modulator...

CC - Organická chemie

  • 2014 - 2015
    • •
  • 1 364 tis. Kč
    • •
  • 1 364 tis. Kč
    • •
  • MŠMT
Project

Mitochondiral diseases caused by depletion and mutation of mitochondrial DNA (ME 226)

of the mitochondrial enzymes analysed with the help of biochemical, immunochemicalInherited mitochondrial diseases caused by disorders in oxidative phosphorylation enzymes represent biochemically, genetically and ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1998 - 2000
    • •
  • 1 040 tis. Kč
    • •
  • 389 tis. Kč
    • •
  • MŠMT
Project

Pathophysiological function of mitochondrial glycerophopsphate dehydrogenase - production of reactive oxygen species (GA303/06/1261)

The purpose of the project is to characterize ROS production by mitochondrial glycerophosphate dehydrogenase (mGPDH) and other mitochondrial enzymes with respect production by particular enzyme complex on mitoc...

CE - Biochemie

  • 2006 - 2008
    • •
  • 4 089 tis. Kč
    • •
  • 4 089 tis. Kč
    • •
  • GA ČR
Project

Mitochondrial diseases caused by inherited disorders of ATP synthase (NR7790)

Characterization of molecular etiopathogenic mechanisms of mitochondrial diseases that are caused by specific defects of mitochondrial ATP synthase due to different mutations in mtDNA ATP6 gene, or by nuclear defects affecting biosy...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2004 - 2006
    • •
  • 6 285 tis. Kč
    • •
  • 4 359 tis. Kč
    • •
  • MZ
Project

Study of molecular basis of cytochrome c oxidase deficiency (GP303/03/D132)

collaboration between Laboratory for study of mitochondrial enzymes also succeeded in deeper characterisation of some known and even new mitochondrial disorders and Department recently discovered several new mutations in g...

FG - Pediatrie

  • 2003 - 2006
    • •
  • 1 511 tis. Kč
    • •
  • 1 511 tis. Kč
    • •
  • GA ČR
Project

Inherited mitochondrial diseases. (IZ4179)

The project is focused at molecular basis of disorders of mitochondrial energyconverting enzymes,in particular the defects of biosynthesis of cytochrome c oxidase,ATPase,and defects in mtDNA encoded subunits of NADH dehydrogenase. W...

FG - Pediatrie

  • 1997 - 1999
    • •
  • 4 209 tis. Kč
    • •
  • 4 194 tis. Kč
    • •
  • MZ
Project

Phosphonate biosynthesis and degradation – a novel mitochondrial pathway involved in global phosphorus turnover? (GM21-19798M)

unexpectedly widespread phosphonate enzymes in eukaryotic genomes and predict that they comprise a novel mitochondrial pathway. To test this, we will computationally map phosphonate enzyme distribution, expression, and cel...

Microbiology

  • 2021 - 2025
    • •
  • 21 111 tis. Kč
    • •
  • 21 111 tis. Kč
    • •
  • GA ČR
Project

Mechanism of ATP synthase biogenesis and the role of TMEM70 protein (GAP303/11/0970)

ATP synthase is the key enzyme of mitochondrial energy provision, responsible for production of most cellular ATP. Enzyme biogenesis results from expression of both nuclear and mtDNA genes encoding 16 different types of

CE - Biochemie

  • 2011 - 2015
    • •
  • 8 963 tis. Kč
    • •
  • 8 963 tis. Kč
    • •
  • GA ČR
Project

Interactions between sulfur metabolism and mitochondrial bioenergetics (GA19-08786S)

The main objective of this research project is to determine to which extent and by which mechanisms the metabolism of sulfur compounds interacts with mitochondrial function. Studies of extremely deranged pathways in genetic models will help...

Biochemistry and molecular biology

  • 2019 - 2022
    • •
  • 10 956 tis. Kč
    • •
  • 10 956 tis. Kč
    • •
  • GA ČR
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