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1 013 (0,095s) •

Project

Modulation of mitochondrial functions in cancer cells by the mitochondrially targeted vitamin E analogues (GAP305/12/1708)

the complexII of the mitochondrial respiratory chain and production of oxidativestress. Our preliminary data suggest that mitochondrially targeted vitamin E analogues (MitoVES) significantly affect mitochondrial transc...

EB - Genetika a molekulární biologie

  • 2012 - 2014
    • •
  • 4 944 tis. Kč
    • •
  • 4 944 tis. Kč
    • •
  • GA ČR
Project

Synthetic lethal interactions of the mitochondrial integrated stress response in MYC-driven tumors (GA25-16629S)

, the mitochondrially activated ISR (mitoISR) restores mitochondrial homeostasis or triggers therapy resistance in aggressive cancers that overexpress MYC transcription factors to the inhibition of mitochondrial ge...

Cell biology

  • 2025 - 2027
    • •
  • 9 694 tis. Kč
    • •
  • 9 694 tis. Kč
    • •
  • GA ČR
Project

Dynamic changes of mitochondrial DNA and transcription profiles in Silene vulgaris (GA521/09/0261)

S. vulgaris is a natural model of mtch genomic fluidity, occurring also in some lineages of crop plants. We aim to analyze in details polymorphism in mitochondrial (mtch) DNA and in the transcription profiles of mtch genes of S. vul...

EB - Genetika a molekulární biologie

  • 2009 - 2012
    • •
  • 2 290 tis. Kč
    • •
  • 2 290 tis. Kč
    • •
  • GA ČR
Project

Mitochondrial DNA genetics in relation to mitochondrial network dynamics and pathogenesis (GAP305/12/1247)

of mitochondrial DNA (mtDNA, clusters of several molecules circular mtDNA and maintenance resting, transcription, and replicative states of mt nucleoids, investigate their redistribution in relation to fission/fusion of mitocho...

EB - Genetika a molekulární biologie

  • 2012 - 2016
    • •
  • 7 635 tis. Kč
    • •
  • 7 635 tis. Kč
    • •
  • GA ČR
Project

Mechanism of ROS generation and mitochondrial permeabilization (GA204/08/0811)

of dimerisation viadisulfide bridges and mitochondrial translocation of Bax, or by transcriptional upregulation of Noxa that removes Mcl-1 from Bak in the mitochondrial outer the molecular mechanism of ROS generation and <...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 4 386 tis. Kč
    • •
  • 4 386 tis. Kč
    • •
  • GA ČR
Project

Role of mitochondrial lipoperoxidation in concert with uncoupling in feedback downregulation of oxidative stress (GA303/07/0105)

We will study a role of mitochondrial lipoperoxidation & mitochondrial of mitochondrial superoxide production exists. Confocal microscopy will be used to study or with silenced cells for UCP2 transcript  (INS1-E). ...

CE - Biochemie

  • 2007 - 2011
    • •
  • 4 900 tis. Kč
    • •
  • 4 900 tis. Kč
    • •
  • GA ČR
Project

Molecular aspects and biochemical and clinical consequences of maternally inherited mitochondrial disorders (NR8065)

Maternally inherited mitochondrial disorders due to mtDNA mutations represent a heterogeneous group of diseases, which predominantly affect the function of tissues mtDNA mutations, the expression of mtDNA genes, stability of the transcri...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 4 910 tis. Kč
    • •
  • 4 909 tis. Kč
    • •
  • MZ
Project

Redox signaling by mitochondrial reactive oxygen species (GA17-01813S)

(diabetes, neurodegenerations, cancer). Mitochondrial superoxide formation and hypoxic and adaptation. We’ll reveal mechanisms of delayed superoxide burst, thus HIF1α transcription reprogramming at hypoxia. We’ll uncover mechanisms...

ED - Fyziologie

  • 2017 - 2019
    • •
  • 6 793 tis. Kč
    • •
  • 6 631 tis. Kč
    • •
  • GA ČR
Project

Can activation of transcription factor Nrf2 attenuate oxidative stress and its consequences following status epilepticus? (GA18-07908S)

Status epilepticus (SE), both in adult and immature brain, is associated with oxidative stress, mitochondrial dysfunction and inflammation.The aim of the project is to determine whether Nrf2/ARE signaling pathway could serve as a therapeutic...

Neurosciences (including psychophysiology)

  • 2018 - 2022
    • •
  • 5 683 tis. Kč
    • •
  • 5 056 tis. Kč
    • •
  • GA ČR
Project

Functional analysis of prohibitin in the primitive flagellate Trypanosoma brucei (GP204/06/P423)

Prohibitins (Phb proteins) are ubiquitous, abundant and evolutionarily highly conserved nuclear encoded mitochondrial proteins that seem to participate in a wide, a correlation between the increased transcription of the Phb gene and...

EB - Genetika a molekulární biologie

  • 2006 - 2008
    • •
  • 341 tis. Kč
    • •
  • 341 tis. Kč
    • •
  • GA ČR
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