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Projects

351 projects (0,19s) •

Project

The mitochondrial genome and oxidative phosphorylation system in metabolic syndrome (OC08017)

Mitochondrial oxidative phosphorylation (OXPHOS) provides most of energy and mitochondrial genes. Dysfunction of OXPHOS are known to cause numerous types of mitochondrial diseases. Mitochondrial malfunction is also...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2008 - 2011
    • •
  • 1 706 tis. Kč
    • •
  • 1 706 tis. Kč
    • •
  • MŠMT
Project

Modulation of mitochondrial functions in cancer cells by the mitochondrially targeted vitamin E analogues (GAP305/12/1708)

the complexII of the mitochondrial respiratory chain and production of oxidativestress. Our preliminary data suggest that mitochondrially targeted vitamin E analogues (MitoVES) significantly affect mitochondrial transcript...

EB - Genetika a molekulární biologie

  • 2012 - 2014
    • •
  • 4 944 tis. Kč
    • •
  • 4 944 tis. Kč
    • •
  • GA ČR
Project

The prevalence and significance of mitochondrial metabolic defects in the myocardium of end-stage heart failure patients (NT14050)

of mitochondrial abnormalities in the myocardial tissue of patients with end-stage heart failure. Changes in structure and function of mitochondrial energetic machinery, mtDNA mutations, degree of heteroplasmy and degree of oxidati...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2013 - 2015
    • •
  • 7 142 tis. Kč
    • •
  • 7 142 tis. Kč
    • •
  • MZ
Project

Imaging of mitochondrial substructure by 3D high resolution microscopy (ME09029)

imaging of mitochondrial network morphology in cells and 3D imaging of superposition of mitochondrial nucleoids (clusters of mtDNA) will be achieved. Fluorescent protein (FP membrane marker proteins. Mitochondrial nucleoid...

EA - Morfologické obory a cytologie

  • 2009 - 2012
    • •
  • 2 376 tis. Kč
    • •
  • 2 376 tis. Kč
    • •
  • MŠMT
Project

Genetic analysis of mitochondrial proteome Integration of mitochondrial-nuclear epistasis with disease phenotypes in the rat (LL1204)

Mitochondria accommodate a number of key metabolic pathways. Mitochondrial. The mammalian mitochondrial proteome is uniquely encoded by two genomes – nuclear and mitochondrial (mtDNA). While mtDNA encodes only 13 proteins, ...

EB - Genetika a molekulární biologie

  • 2012 - 2017
    • •
  • 46 094 tis. Kč
    • •
  • 46 094 tis. Kč
    • •
  • MŠMT
Project

Acquisition of the mitochondrial genome by cells with damaged mitochondrial DNA restores the mitochondrial function and tumorigenic capacity (GA15-02203S)

of mitochondria. mtDNA acquisition resulted in gradual recovery in the mitochondrial function mitochondrial transfer, the recovery of mitochondrial function, the cross-talk (retrograde documents intercellular mitochond...

EB - Genetika a molekulární biologie

  • 2015 - 2017
    • •
  • 6 897 tis. Kč
    • •
  • 6 897 tis. Kč
    • •
  • GA ČR
Project

New biological methods in prenatal diagnosis of mitochondrial diseases. (IZ4035)

Electrophoretical,functional and molecular biological analysis of mitochondrial oxidative phosphorylation proteins in early stages of intrauterine development with perspective of prenatal diagnostics in families with mitochondrial e...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1997 - 1999
    • •
  • 3 810 tis. Kč
    • •
  • 3 510 tis. Kč
    • •
  • MZ
Project

Tower of Babel Mitochondrial-nuclear interactions in the gynodioecious species Silene vulgaris investigated with transcriptomics. (GA16-09220S)

Plant mitochondrial genomes are highly rearranged. We propose to utilize an unprecedented level of intraspecific diversity in plant mitochondrial DNA described in Silene vulgaris for the investigation of mitochondrial-nucle...

EF - Botanika

  • 2016 - 2020
    • •
  • 4 964 tis. Kč
    • •
  • 4 857 tis. Kč
    • •
  • GA ČR
Project

Mitochondrial energetic metabolism in neonatal period (NT11186)

The development of new noninvasive methods for diagnostics of mitochondrial disorders in minimal amount of samples is crucial for analysis of mitochondrial of mitochondrial disorders in neonates, enable early genetic counse...

FG - Pediatrie

  • 2010 - 2014
    • •
  • 9 836 tis. Kč
    • •
  • 9 836 tis. Kč
    • •
  • MZ
Project

New diagnostic algorithms for mitochondrial disorders in children (NT14156)

Mitochondrial diseases are characterized by the broad spectrum of clinical symptoms and a very high degree of genetic heterogeneity. This may lead to significant clinical course of mitochondrial disorders in children of post-newborn...

FG - Pediatrie

  • 2013 - 2015
    • •
  • 4 830 tis. Kč
    • •
  • 4 830 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 351