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16 985 (0,107s) •

Project

Expression of biotransformation enzymes in primary liver cancers (NV17-28231A)

in primary liver cancer, namely hepatocellular carcinoma (HCC). Hepatocytes constitute approx. 80% of liver cell population and form a major biotransformation organ of the human body. Biotransformation affects drug levels ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2017 - 2021
    • •
  • 14 965 tis. Kč
    • •
  • 14 565 tis. Kč
    • •
  • MZ
Project

Cost effectiveness of population-based breast cancer screening in the conditions of the Czech Republic (NO6483)

Verification of cost effectiveness of population-based breast cancer screening in the conditions of the CR through a data model. Standardised screening with quality control is one of the most effective interventions.......

FQ - Veřejné zdravotnictví, sociální lékařství

  • 2001 - 2003
    • •
  • 1 355 tis. Kč
    • •
  • 1 208 tis. Kč
    • •
  • MZ
Project

Electrophilic fatty acids as the important regulators of cellular response to irradiation, genome instability, and carcinogenesis. (GA19-09212S)

electrophilic fatty acids in organism and their potential future usage as the anti-cancer and anti-fibrotic activities described in different models. Some new aspects of NO2-FA action in regulation of cancer cell ...

Cell biology

  • 2019 - 2023
    • •
  • 9 109 tis. Kč
    • •
  • 9 076 tis. Kč
    • •
  • GA ČR
Project

3D yeast colony genomics A model for cancer progression and development of drug resistance in biofilms (7F14083)

colonies and tumor-affected organism and of those regarding defense strategies and signaling within organized yeast communities such as colonies and biofilms have revealed an excellent simple model for investigati...

EB - Genetika a molekulární biologie

  • 2014 - 2017
    • •
  • 25 076 tis. Kč
    • •
  • 25 076 tis. Kč
    • •
  • MŠMT
Project

Role of internal time-keeping system in pathogenesis of colorectal cancer (GA13-08304S)

observed in time-shift workers, are significantly associated with a higher cancer risk tumorigenesis in colon. Here we wish to test this hypothesis using mouse model of colorectal cancer (CRC), human colon adenocarcinoma c...

ED - Fyziologie

  • 2013 - 2017
    • •
  • 7 406 tis. Kč
    • •
  • 7 406 tis. Kč
    • •
  • GA ČR
Project

A study of immunological answer after tumour devitalization in different animal models (GA524/04/0102)

in whole organism including metastases and no relapses were observed. It was explained of devitalization in three different rodent models - mouse melanoma, rat colorectal carcinoma and rat sarcoma. Their progression caused a death ...

EC - Imunologie

  • 2004 - 2006
    • •
  • 6 374 tis. Kč
    • •
  • 4 354 tis. Kč
    • •
  • GA ČR
Project

Utilization of molecular techniques for study of the biological activity of plant derived compounds (1P04OC926.001)

We plan to focus our interest mainly to the area of plat-derived compounds influenced cancer - both with cancero-static and cancer-promoting affect......

CE - Biochemie

  • 2004 - 2007
    • •
  • 5 016 tis. Kč
    • •
  • 1 600 tis. Kč
    • •
  • MŠMT
Project

Screening for and characterization of novel, apoptosis inducing surface molecules of human hematopoietic cells (GA301/99/0350)

as during the postnatal life of an organism. Disruption of its regulation could be one of the causes of such serious human maladies as cancer, various immunodeficiencies and neurodegenerative diseases. The decreased sensitivity of ...

EB - Genetika a molekulární biologie

  • 1999 - 2001
    • •
  • 1 689 tis. Kč
    • •
  • 1 565 tis. Kč
    • •
  • GA ČR
Project

Mechanism of procathepsin D effect on breast cancer cells (IAA501630801)

and cancer cell lines. Increased level of pCD is known to affect multiple stages of tumor how the pCD affects cancer cells. Full understanding of this mechanism prognosis of various cancers. It has been s...

EB - Genetika a molekulární biologie

  • 2008 - 2011
    • •
  • 3 664 tis. Kč
    • •
  • 3 664 tis. Kč
    • •
  • AV ČR
Project

Hedgehog-GLI signalling an indicator of the tumor biological behavior in melanoma, lung cancer and some other tumors and its blocking as an antitumor therapy (NT14005)

models, and immunohistochemical staining. The aim will be focused on identifying new GLI target in these tumors, to determine an affective block of HH as a model and is aberrantly activated in many types of cancers

FD - Onkologie a hematologie

  • 2013 - 2015
    • •
  • 8 475 tis. Kč
    • •
  • 8 475 tis. Kč
    • •
  • MZ
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