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Projects
Modified nucleosides, nucleotides and oligonucleotides and their application in biomedicine (TA03010598)
Modified nucleosides, nucleotides and oligonucleotides are intensively used in medicine mainly as drugs or as components of diagnostic kits. The project is focused of modified oligonucleotides ? hybridisation probes which w...
EB - Genetika a molekulární biologie
- 2013 - 2016 •
- 15 280 tis. Kč •
- 9 880 tis. Kč •
- TA ČR
Řešení projektu: 1. 1. 2013 - 31. 12. 2016
Uznané náklady
Podpora ze státního rozpočtu (65%)
Poskytovatel: Technologická agentura ČR
The novel type of oligonucleotides composed of pyrrolidine nucleosides and enzymaticaly stable phosphonate internucleotide bond (GP203/02/D150)
Novel type of oligonucleotides based on pyrrolidine nucleosides synthesis of the modified oligonucleotides. Tartaric acid would be the key starting material for preparation of pyrrolidine nucleosides. It will react with app...
CC - Organická chemie
- 2002 - 2005 •
- 2 132 tis. Kč •
- 704 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2002 - 1. 1. 2005
Uznané náklady
Podpora ze státního rozpočtu (33%)
Poskytovatel: Grantová agentura České republiky
Towards cyclohexenyl and cyclohexyl locked nucleic acids (GPP207/12/P625)
applicabilityof these modified nucleosides. Further aims of the study are the evaluationThis project is focused on the synthesis of new conformationally locked nucleosides and nucleotides and their incorporation into struc...
CC - Organická chemie
- 2012 - 2014 •
- 3 643 tis. Kč •
- 3 643 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2012 - 31. 12. 2014
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Combinatorial and rational approaches for the synthesis and evaluation of novel modified nucleosides with cytostatic and antimicrobial activity (GAP207/11/0344)
By combining of systematic synthesis of derivatives and analogues of active compounds, combinatorial approaches and rational design, we propose to device and prepare series of novel nucleoside derivatives and screen them for cytostatic and i...
CC - Organická chemie
- 2011 - 2015 •
- 24 168 tis. Kč •
- 24 168 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2011 - 31. 12. 2015
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Modified oligonucleotides derived from 5´-substituted nucleoside 5´-C-phosphonates synthesis and hybridization properties (GP203/04/P273)
Modified oligonucleotides containing the 3´-O-P-CH(R)-5´´ internucleotide linkages derived from 5´-substituted nucleoside 5´-C-phosphonates in the project, and their physico-chemical properties will be studied and the influence of 5...
CC - Organická chemie
- 2004 - 2006 •
- 806 tis. Kč •
- 806 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2004 - 1. 1. 2006
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Structure and Properties of Modified Components of Nucleic Acids (GA13-24880S)
and properties of the modified components of nucleic acids (MCNA), i.e. modified nucleobases, nucleosides and nucleotides, by means of experimental NMR (high-resolution liquid NMR......
CB - Analytická chemie, separace
- 2013 - 2015 •
- 6 006 tis. Kč •
- 6 006 tis. Kč •
- GA ČR
Řešení projektu: 1. 2. 2013 - 31. 12. 2015
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Targeted damage of the DNA repair mechanisms as a tool for cancer therapy (NV15-31604A)
enzymes with the model DNA duplexes modified in critical sites with the structurally diverse unnatural nucleotide units (nucleoside analogs and/or phosphonate types the whole pathway from the design and synthesis of nucleoside<...
EB - Genetika a molekulární biologie
- 2015 - 2018 •
- 17 562 tis. Kč •
- 17 562 tis. Kč •
- MZ
Řešení projektu: 1. 5. 2015 - 31. 12. 2018
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
Syntheses of new prodrug forms of biologically active nucleotide analogues (GA14-00522S)
acyclic nucleoside phosphonates thus far not clinically developed and their transformation to novel non-toxic prodrugs mostly based on peptidomimetics or modified amino potential of acyclic nucleoside phosphonates as antit...
CC - Organická chemie
- 2014 - 2016 •
- 4 481 tis. Kč •
- 4 481 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2014 - 31. 12. 2016
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Grantová agentura České republiky
Synthetic analogues of nucleoside triphosphate transporters development and applications (GA17-14791S)
Modified nucleoside triphosphates (NTPs) are important metabolites in medicinal chemistry and cell biology. Currently, nucleosides capable of penetrating cell membranes are applied to cell cultures. In order to be active me...
CC - Organická chemie
- 2017 - 2021 •
- 6 547 tis. Kč •
- 5 422 tis. Kč •
- GA ČR
Řešení projektu: 1. 1. 2017 - 31. 12. 2021
Uznané náklady
Podpora ze státního rozpočtu (83%)
Poskytovatel: Grantová agentura České republiky
Novel antivirals and antineoplastics (1QS400550501)
on nucleoside, nucleotide and nucleobase structure, to determine their transport for preclinical phase of drug development. The project concerns five groups of modified) purine nucleosides with potential cytostatic or anti...
CC - Organická chemie
- 2005 - 2009 •
- 20 500 tis. Kč •
- 20 500 tis. Kč •
- AV ČR
Řešení projektu: 1. 1. 2005 - 31. 12. 2009
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Akademie věd České republiky
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