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4 206 (0,106s) •

Project

Intestinal organoids as an in-vitro model for predicting the response to therapies correcting molecular defects in cystic fibrosis (NU20-07-00049)

that the therapeutic response is also affected by non-CFTR genes, called disease modifying CFTR genotype. Modifying genes that can contribute to individualised response modulators. Genotyping of SNPs in these ...

Paediatrics

  • 2020 - 2023
    • •
  • 11 461 tis. Kč
    • •
  • 11 461 tis. Kč
    • •
  • MZ
Project

Development of transgenic tissue lines of spruce (Picea abies) showing high toxicity towards bark beatle (Scolytidae) species. (QH71290)

. Modified versions of cry3A genes will be expressed in E. coli and toxicity tested in vivo. Transgenic spruce embryogennic lines expressing modified cry3A genesBacillus thuringiensis var. tenebrionis delta-endotox...

GK - Lesnictví

  • 2007 - 2011
    • •
  • 10 681 tis. Kč
    • •
  • 10 672 tis. Kč
    • •
  • MZe
Project

Resistance to antibiotics and new derivatives of antibiotics for medical purposes. (PZ-Z2/23)

New or modified antibiotics with improved physico-chemical properties and therapeutic effects. Development of new derivates of lincosamine antibiotics by means of gene engineering or biotransformation.......

FR - Farmakologie a lékárnická chemie

  • 1997 - 2001
    • •
  • 28 602 tis. Kč
    • •
  • 11 300 tis. Kč
    • •
  • MH
Project

Disorders caused by MECP2 mutations in Czech Republic and other genetic factors influencing their phenotype (NT13120)

phenotype with genotypes of functional polymorphisms in several candidate modifier genes.Mutations in the MECP2 gene are mostly identified in patients with Rett syndrome, a severe pervasive developmental disorder and one o...

FH - Neurologie, neurochirurgie, neurovědy

  • 2012 - 2015
    • •
  • 7 663 tis. Kč
    • •
  • 7 663 tis. Kč
    • •
  • MZ
Project

Hybridisation within the wheat (Triticum aestivum)-Elytrigia intermedia-E. repens species complex a probable case of crop - wild relative gene flow (GA206/05/0778)

in agro- and natural ecosystems. Because we know that gene flow can occur but we don't know how the genes can influence natural ecosystems, it is necessary to evaluate the possibility of gene flow before the genetically

EF - Botanika

  • 2005 - 2007
    • •
  • 2 871 tis. Kč
    • •
  • 2 871 tis. Kč
    • •
  • GA ČR
Project

Treatment of spinal cord injury via targeted inhibition of the inflammasome with gene therapy stimulation of motor pathway axon regeneration (LUAUS25141)

of b) gene therapy of modified PI3Kdelta into the motor cortex. This form and inhibition of inflammatory signaling. 2. Validation of modified exosomes in a rat spinal cord injury model 3. Combination of modified e...

Neurosciences (including psychophysiology)

  • 2025 - 2028
    • •
  • 8 502 tis. Kč
    • •
  • 8 502 tis. Kč
    • •
  • MŠMT
Project

Artificial epigenetics Development of a eukaryotic bioorthogonal transcription system for gene expression manipulation in the cell. (GA17-03419S)

Natural DNA modifications are epigenetic signals that are vital for regulation of gene expression. Artificial DNA modifications possess immense potential) and/or transcription factors interact with DNA. We propose to create DNA templates

EB - Genetika a molekulární biologie

  • 2017 - 2019
    • •
  • 9 537 tis. Kč
    • •
  • 9 072 tis. Kč
    • •
  • GA ČR
Project

Research and utilization of genetic mechanisms of wheat governing resistance to rusts, powdery mildew and Fusarium head blight. (EP0960996415)

resistance genes and other genes affecting expression of resistance genes (modifiers and occurrence of new virulences new resistance genes have to be searched for, and genetic background of disease resist...

GE - Šlechtění rostlin

  • 1996 - 1999
    • •
  • 7 280 tis. Kč
    • •
  • 7 080 tis. Kč
    • •
  • MZe
Project

Gene therapy of virus - induced tumors (GA312/96/1211)

on the utilization of the suicide genes, which are capable of making tumour cells sensitive to otherwise non-toxic drugs and to the nature of the interaction between gene-modified of some of the problems of gene t...

EB - Genetika a molekulární biologie

  • 1996 - 1998
    • •
  • 6 290 tis. Kč
    • •
  • 5 990 tis. Kč
    • •
  • GA ČR
Project

Functional modulation of chromatin-modifying enzymes by nuclear phosphoinositides (GA17-09103S)

are crucial for regulation of gene expression and development. Although a lot is known and development. We plan to identify chromatin-modifying enzymes that interact with nuclear in these chromatin modifying complexes both...

EB - Genetika a molekulární biologie

  • 2017 - 2019
    • •
  • 9 384 tis. Kč
    • •
  • 8 589 tis. Kč
    • •
  • GA ČR
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