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9 232 (0,137s) •

Project

*Modulators of skin barrier properties and their use in drugs formulation. (FT-TA2/012)

*Research and development oriented towards new modulators of the skin barrier properties and preparations for dermal and transdermal delivery of active substances in pharmacy or cosmetics. Elaboration of data for i...

FR - Farmakologie a lékárnická chemie

  • 2005 - 2007
    • •
  • 22 129 tis. Kč
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  • 9 950 tis. Kč
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  • MPO
Project

Understanding the mechanisms of epidermal lipid barrier formation, damage and repair implications for skin diseases (GA25-17203S)

in the experimentally perturbed skin lipid barrier with the potential for the therapy of skinThe main protective barrier of our body, necessary for terrestrial survival, is primarily located in the intercellular m...

Pharmacology and pharmacy

  • 2025 - 2027
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  • 11 956 tis. Kč
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  • 11 704 tis. Kč
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  • GA ČR
Project

Lipid membrane models – a new tool for studying pathophysiology of skin diseases at a molecular level (GA13-23891S)

membrane models of the lipid skin barrier in atopic dermatitis and other skin diseases, their precursors and degradation products, for a competent/incompetent skin barrier of correcting the properties...

FR - Farmakologie a lékárnická chemie

  • 2013 - 2017
    • •
  • 9 734 tis. Kč
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  • 9 734 tis. Kč
    • •
  • GA ČR
Project

Novel Insights into the Nanostructure of the Skin Lipid Barrier by Biophysical Methods (GF22-20839K)

The skin lipid barrier, an extracellular ceramide-based multilamellar lipid understanding of the lipid function in healthy and diseased skin lipid barrier. mechanisms and conditions of lipid assembly into a functio...

Biophysics

  • 2022 - 2025
    • •
  • 7 911 tis. Kč
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  • 7 911 tis. Kč
    • •
  • GA ČR
Project

Synthesis and structure-activity relationships of skin ceramides and agents targeting them (GAP207/11/0365)

components of the skin barrier. The methodical approach combines knowledge from the field changes on the skin barrier function. To gain more mechanistic insight, permeability target the ceramide membranes in the <...

FR - Farmakologie a lékárnická chemie

  • 2011 - 2013
    • •
  • 2 034 tis. Kč
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  • 2 034 tis. Kč
    • •
  • GA ČR
Project

Interdependencies between Inflammatory Processes and Barrier Lipids in Diseased Skin (GC16-25687J)

of the physiological processes leading to a competent skin barrier and disturbances in skin biology and lipid chemistry and biophysics, we will study how pro-inflammatory cytokines and immune cells influence the formation ...

FR - Farmakologie a lékárnická chemie

  • 2016 - 2018
    • •
  • 7 313 tis. Kč
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  • 7 313 tis. Kč
    • •
  • GA ČR
Project

Corneocyte lipid envelope lipid-protein binding mechanisms and barrier rescue in ichthyosis models (GA24-10736S)

as the role of CLE in skin barrier. Since oxidized acylceramides have a potential in skin barrier. In collaboration with University Toulouse, we will study the possibilities of the skin barrier r...

Biophysics

  • 2024 - 2026
    • •
  • 8 301 tis. Kč
    • •
  • 8 301 tis. Kč
    • •
  • GA ČR
Project

Ultralong chain ceramides in membrane models of healthy and diseased skin barrier (GC19-09135J)

-periodicity lamellar phases in the skin barrier, which are essential components for life organization of the skin lipid barrier to environmental stressors that are encountered envelope in healthy skin and...

Biophysics

  • 2019 - 2021
    • •
  • 7 012 tis. Kč
    • •
  • 6 957 tis. Kč
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  • GA ČR
Project

Integrated design methodology of nanoformulation processes for (trans-)dermal delivery of actives (GA19-09600S)

and lipid model membranes which will imitate both the healthy and diseased skin barrier parameters for different types of nanoformulations, their physico-chemical properties and performance on skin absorption for ...

Pharmacology and pharmacy

  • 2019 - 2023
    • •
  • 9 552 tis. Kč
    • •
  • 9 289 tis. Kč
    • •
  • GA ČR
Project

The effect of anti IL-17 therapy on skin and gut microbiota and intestinal barrier function in psoriasis patients (NU22J-05-00056)

the integrity of the skin barrier as well. New biomarkers associated with the composition. In addition, we will analyze the markers of compromised skin- and gut barrier integrity virulent commensal strains that ca...

Immunology

  • 2022 - 2025
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  • 6 524 tis. Kč
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  • 6 524 tis. Kč
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  • MZ
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