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Projects

12 projects (0,096s) •

Project

Effects of perioperative opioid analgesia on circulating tumor cells in colorectal cancer multicenter randomized clinical trial (NV18-03-00470)

in the early postoperative period and that morphine- but not piritramide-based PA increases of morphine- and piritramide-based PA on CTCs presence in laparoscopic CRC surgery comparing effects of epidural, morphine- and pi...

Oncology

  • 2018 - 2022
    • •
  • 15 056 tis. Kč
    • •
  • 14 993 tis. Kč
    • •
  • MZ
Project

Selection of diagnostic markers of the long-term effect of multifunctional peptide agonists and antagonists targeting µ-, δ- and κ-opioid receptors – search for new possibilities for treatment of chronic pain. (LTAUSA18110)

to morphine for the same period of time. Based on this comparison we shall try to characterize the difference between changes induced by morphine with those induced by a given peptide. In parallel with these experiments, the effect...

Biochemistry and molecular biology

  • 2019 - 2022
    • •
  • 4 982 tis. Kč
    • •
  • 4 982 tis. Kč
    • •
  • MŠMT
Project

Molecular mechanisms of adverse and protective effects of morphine and methadone on the rat heart (IAA501110901)

This project will assess the impact of sustained administration of varying doses of morphine and/or methadone on opioid and adrenergic signaling in the rat heart. A special attention will be devoted to investigating the presumed cardioprotec...

ED - Fyziologie

  • 2009 - 2013
    • •
  • 7 683 tis. Kč
    • •
  • 7 683 tis. Kč
    • •
  • AV ČR
Project

The development of the screening method and the searching of poppy (Papaver somniferum) gene ressources with high thebaine content (GA521/98/0512)

in the morphine syntheses line, therefore it is highly probable that the mutant will exist with the inhibition of thebain conversion to the morphine. The aim othis project is to elaborate......

GC - Pěstování rostlin, osevní postupy

  • 1998 - 2000
    • •
  • 1 271 tis. Kč
    • •
  • 1 271 tis. Kč
    • •
  • GA ČR
Project

Consequences of sustained morphine treatment and withdrawal on the rat brain proteomic and functional studies (GA19-03295S)

Threre is a number of studies dealing with chronic morphine-induced alterations in brain tissue but very little attention has been devoted to withdrawal of the drug. Our current proteomic results pointed out that 20-day withdrawal of the dru...

Physiology (including cytology)

  • 2019 - 2022
    • •
  • 7 821 tis. Kč
    • •
  • 7 767 tis. Kč
    • •
  • GA ČR
Project

Experimental therapy of opiate dependence with psychotropic drugs behavioural and neurobiological aspects. (NF5513)

Repeated morphine administrations: changes/disorders of social behaviour in animal models, therapeutic effects of benzodiazepines, GABA changes studied with RT-PCR an mcrodialysis......

FH - Neurologie, neurochirurgie, neurovědy

  • 1999 - 2001
    • •
  • 2 294 tis. Kč
    • •
  • 2 294 tis. Kč
    • •
  • MZ
Project

The role of appetite regulating peptides in opioid and alcohol dependence. (NT13687)

want to study the role of ghrelin, orexin, insulin, leptin in the opioid (morphine...

FR - Farmakologie a lékárnická chemie

  • 2012 - 2014
    • •
  • 2 654 tis. Kč
    • •
  • 2 654 tis. Kč
    • •
  • MZ
Project

Subcellular distribution of mu- and delta-opioid receptors and functional activity of trimeric G proteins after the long-term morphine stimulation. (GA309/06/0121)

Drug addiction represents a worldwide problem with negative impacts on both drug abusers and society. Opiates bind to receptors expressed in the central nervous(CNS) as well as cells of the immune system. Since direct and reciprocal hormone-mediated ...

ED - Fyziologie

  • 2006 - 2008
    • •
  • 3 975 tis. Kč
    • •
  • 3 975 tis. Kč
    • •
  • GA ČR
Project

Active drug-seeking behavior in prenatally methamphetamine-exposed adult male and female rats (NS10509)

The aim of the planned project is to determine the effect of prenatal methamphetamine (MA) exposure on drug-seeking behavior in adulthood. The following drugs will be tested: (1) the same drug as prenatally (MA); (2) the related drugs (amphetamine, c...

FH - Neurologie, neurochirurgie, neurovědy

  • 2009 - 2011
    • •
  • 3 151 tis. Kč
    • •
  • 3 151 tis. Kč
    • •
  • MZ
Project

Diagnostic methods for laboratory control of Papaver L. authenticity (QK1720263)

Development and validation of diagnostic methods for reliable determination of authenticity of poppy seeds (Papaver somniferum L., var.) in marketed commodities. Official (food) control laboratories will be provided with standardized procedures based...

GM - Potravinářství

  • 2017 - 2019
    • •
  • 11 043 tis. Kč
    • •
  • 11 043 tis. Kč
    • •
  • MZe
  • 1 - 10 out of 12