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10 724 (0,149s) •

Project

Pathophyziologie of Chronic Myelogenous Leukemia - Cellular and Mouse Model of the Disease (NC6652)

Cellular lmodel of ligand-inducible and constitutively active abl PTK created by knock-in to our already developed EPOR-tagged ES cells, in vitro differentiation of these cell lines. Role of growth factors in leukemogenesis of CML. Mouse

FD - Onkologie a hematologie

  • 2001 - 2004
    • •
  • 3 692 tis. Kč
    • •
  • 3 592 tis. Kč
    • •
  • MZ
Project

Czech node of INFRAFRONTIER - The European infrastructure for phenotyping and archiving of model mammalian genomes (7E12089)

of genetically modified mouse models, their cryo-archiving, and their distribution fields: archiving and distribution of mouse models/mutants (Archivefrontier/EMMA, European mouse mutant archive) and phen...

EB - Genetika a molekulární biologie

  • 2012 - 2012
    • •
  • 295 tis. Kč
    • •
  • 295 tis. Kč
    • •
  • MŠMT
Project

New mouse model of human aneuploidy syndromes (GA301/06/1334)

mechanisms. The existing mouse models could not be used to distinguish between the alternative hypotheses because all triplicated the mouse orthologs of human chr21 genes. To make such distinction possible in this project,...

EB - Genetika a molekulární biologie

  • 2006 - 2008
    • •
  • 2 957 tis. Kč
    • •
  • 2 957 tis. Kč
    • •
  • GA ČR
Project

Analysis of Extracellular Niche in Mouse Models of Liver Fibrosis (GA18-02699S)

). Using mouse models, we propose to analyze changes in composition of ECM during and altering ECM niche, using newly developed mouse model harboring HSCs with compromized HSC line and mouse primary HSCs t...

Cell biology

  • 2018 - 2022
    • •
  • 8 694 tis. Kč
    • •
  • 7 813 tis. Kč
    • •
  • GA ČR
Project

Deciphering cellular and molecular principles of choroid plexus development (GA25-17360S)

mouse models for lineage tracing and targeted depletion of selected cell types mouse models, will have the potential to boost the knowledge of ChP development will use a combination of single-cell RNA sequencing a...

Cell biology

  • 2025 - 2027
    • •
  • 15 185 tis. Kč
    • •
  • 15 002 tis. Kč
    • •
  • GA ČR
Project

Proteomic analysis of mouse model of hereditary hemochromatosis (GA303/04/0003)

differences in protein expression between mouse model of HH (HFE-knockout mouse) and control mouse intwo tissues critical for iron metabolism - intestinal absorptive......

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2004 - 2006
    • •
  • 3 318 tis. Kč
    • •
  • 2 658 tis. Kč
    • •
  • GA ČR
Project

Effect of DNA copy number variation on fertility of the house mouse (GA16-19158S)

hybrid sterility gene. Prdm9 participates in our mouse models of complete sterility, fertility, and the transmission of copy number variation in our mouse modelsThe PRDM9 protein is an epigenetic factor necessary ...

EB - Genetika a molekulární biologie

  • 2016 - 2020
    • •
  • 4 979 tis. Kč
    • •
  • 4 733 tis. Kč
    • •
  • GA ČR
Project

Rudiments in the mouse model of tooth development (GAP305/12/1766)

in the mouse odontogenesis model, in reality, exclusively concerns rudimentary structures modified mouse strains. Using cre-lox technology, live imaging, in situ hybridization......

EA - Morfologické obory a cytologie

  • 2012 - 2016
    • •
  • 11 005 tis. Kč
    • •
  • 11 005 tis. Kč
    • •
  • GA ČR
Project

Genetic disection of multigenetic predisposition to disease in the mouse model (OK 394)

Tumour of strangulate and procedure to the Leishnania major...

FD - Onkologie a hematologie

  • 1999 - 2001
    • •
  • 5 085 tis. Kč
    • •
  • 1 515 tis. Kč
    • •
  • MŠMT
Project

New strategy for alleviating allergic response Effect of surface bacterial antigens in the prevention and treatment of allergic inflammation in mouse model (8JPL19046)

development in mouse model of airway allergy. We foresee that chemically characterized of allergic immune reaction in mouse model of airway allergy. Unique complementary their immunomodulatory properties in in v...

Microbiology

  • 2019 - 2021
    • •
  • 120 tis. Kč
    • •
  • 117 tis. Kč
    • •
  • MŠMT
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