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552 (0,073s) •

Project

Role of internal time-keeping system in pathogenesis of colorectal cancer (GA13-08304S)

tumorigenesis in colon. Here we wish to test this hypothesis using mouse model of colorectal cancer (CRC), human colon adenocarcinoma cell lines and their subcutaneous xenografts......

ED - Fyziologie

  • 2013 - 2017
    • •
  • 7 406 tis. Kč
    • •
  • 7 406 tis. Kč
    • •
  • GA ČR
Project

Upgrade of the Czech Centre for Phenogenomics developing towards translation research (EF16_013/0001789)

on the aging process genes involved in this process) and oncology (patient xenografts, PDX for the characterization of tumor xenografts including metabolomics. - Testing drugs against cancer.......

EI - Biotechnologie a bionika

  • 2017 - 2020
    • •
  • 62 149 tis. Kč
    • •
  • 62 149 tis. Kč
    • •
  • MŠMT
Project

The canonical Wnt pathway components involved in non-canonical signaling mechanisms (GA18-26324S)

transgenic mouse models, intestinal organoid cultures, and xenografts. The results will be employed to identify the composition of LGR4 protein complexes in mouse intestinal......

Cell biology

  • 2018 - 2022
    • •
  • 9 615 tis. Kč
    • •
  • 8 721 tis. Kč
    • •
  • GA ČR
Project

Cellular and molecular mechanisms of xenotransplantation reaction. Experimental model of corneal transplantation. (NR7816)

during rejection of xenografts and to exploration of the functional role of cytokines survival of corneal xenografts....

EC - Imunologie

  • 2004 - 2006
    • •
  • 2 054 tis. Kč
    • •
  • 2 054 tis. Kč
    • •
  • MZ
Project

Engineered antibodies as platforms for cancer imaging and therapy (GA18-04790S)

using the mouse xenograft model of prostate cancer....

Health-related biotechnology

  • 2018 - 2022
    • •
  • 7 999 tis. Kč
    • •
  • 7 999 tis. Kč
    • •
  • GA ČR
Project

Role of novel suspect molecules associated with resistance of cancer cells to taxanes (GA19-03063S)

in response of corresponding mouse tumor xenografts to taxanes in vivo. We hope that data...

Biochemistry and molecular biology

  • 2019 - 2023
    • •
  • 9 685 tis. Kč
    • •
  • 9 613 tis. Kč
    • •
  • GA ČR
Project

Vascular conduits derived from decellularized cadaveric donor tissues modified with stem cells and 3D bioprint (NW24J-02-00061)

/xenografts do not produce better results than prostheses. The objective is to create existing methods: vascular xenografts and allografts; decellularization; 3D bioprint cells (WJ-MSCs); and cryopreservation. We aim to use preferab...

Cardiac and Cardiovascular systems

  • 2024 - 2027
    • •
  • 6 844 tis. Kč
    • •
  • 6 844 tis. Kč
    • •
  • MZ
Project

New prognostic and predictive markers in patients with mantle cell lymphoma at diagnosis and on treatment (NV17-28980A)

therapy of relapsed MCL, and 5. characterization of new PDX (patient derived xenograft...

FD - Onkologie a hematologie

  • 2017 - 2020
    • •
  • 19 831 tis. Kč
    • •
  • 19 831 tis. Kč
    • •
  • MZ
Project

Humanized patient-derived murine xenografts for experimental therapy of hematologic malignancies and for the study of in vivo acquired drug-resistance (NV19-08-00144)

Hematologic malignancies represent 5th most common type of tumor in the Czech Republic. Patient-derived murine xenografts (PDXs) derived by injection of primary tumor cells into immunodeficient mice became standard tools for confirmation of ...

Hematology

  • 2019 - 2022
    • •
  • 16 966 tis. Kč
    • •
  • 16 966 tis. Kč
    • •
  • MZ
Project

Uncovering the mechanism underlying the tumor-suppressive effects of miR-215 and its substitution as new therapeutic strategy in colorectal cancer (GA16-18257S)

One of the most significantly down-deregulated miRNAs in colorectal cancer (CRC) is miR-215. Our team has previously shown that its expression in tumour tissue is significantly decreased in comparison to adjacent colon tissue and low levels of miR-21...

FR - Farmakologie a lékárnická chemie

  • 2016 - 2020
    • •
  • 7 158 tis. Kč
    • •
  • 6 756 tis. Kč
    • •
  • GA ČR
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