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5 087 (0,114s) •

Project

P-glycoprotein and its possible contribution to development of resistance to Imatinib in Bcr-Abl expressing cells (NR9482)

Study of the P-gp contribution to the development of resistance to imatinib in Bcr-Abl positive cells using the direct determination of intracellular content of the drug.......

FD - Onkologie a hematologie

  • 2007 - 2009
    • •
  • 3 184 tis. Kč
    • •
  • 3 116 tis. Kč
    • •
  • MZ
Project

Testing of the new compounds with potential for resistance modulation in multi drug resistant strains (LTC19007)

the activity of transmembrane transporters responsible for multiple drug resistance with the potential to inhibit multiple drug resistance will be tested. These will be substances of the samples will be tested on ...

Microbiology

  • 2019 - 2022
    • •
  • 3 360 tis. Kč
    • •
  • 3 360 tis. Kč
    • •
  • MŠMT
Project

Rare and uncommon flavonolignans Chemo-enzymatic preparation and pharmacological activity (GA18-00150S)

signalization, and their inhibitory activities towards multi-drug resistance (MDR) proteins...

Biochemical research methods

  • 2018 - 2020
    • •
  • 7 591 tis. Kč
    • •
  • 6 859 tis. Kč
    • •
  • GA ČR
Project

Development of Novel Antituberculosis Agents and Prodrugs Effective against Multidrug Resistant Tuberculosis (MEB091034)

, minor multi drug resistance, minimum of side effects, high index selectivityOur investigation is based on molecular modelling of new anti-tuberculosis drugs and prodrugs, their synthesis, antimycobacterial activi...

FR - Farmakologie a lékárnická chemie

  • 2010 - 2011
    • •
  • 112 tis. Kč
    • •
  • 112 tis. Kč
    • •
  • MŠMT
Project

Transporters of the pathogenic Candida yeast species as a target for the development of new antifungal drugs. (GA16-03398S)

conditions, including the presence of antifungal drugs. This project focuses on Candida to proliferate in adverse conditions and to resist to stresses caused by the presence of various drugs. We will exploit several approa...

EE - Mikrobiologie, virologie

  • 2016 - 2018
    • •
  • 4 888 tis. Kč
    • •
  • 4 713 tis. Kč
    • •
  • GA ČR
Project

Antibakteriální bariéra u náhrad lidských kloubů (EI22_002/0000934)

The goal of the project is therefore to create a multi-stage antibacterial barrier, which in the first case will prevent the transmission of infection during the patient's organism is significantly weakened, it will support resistance

Microbiology

  • 2023 - 2026
    • •
  • 15 207 tis. Kč
    • •
  • 0 tis. Kč
    • •
  • MPO
Project

Oncoproteomics Centre (LC07017)

, induction of multidrug resistance, proteomic signatures of anticancer drugs in treated of tumor-drug interactions. Oncoproteomics Centre - research consortium of recognized......

FD - Onkologie a hematologie

  • 2007 - 2011
    • •
  • 58 620 tis. Kč
    • •
  • 57 794 tis. Kč
    • •
  • MŠMT
Project

Targets for Chemotherapy and Drug Resistance in Anaerobic Protozoan Parasites (OC B22.001)

Targets for Chemotherapy and Drug Resistance in Anaerobic Protozoan Parasites...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2003 - 2006
    • •
  • 4 199 tis. Kč
    • •
  • 1 897 tis. Kč
    • •
  • MŠMT
Project

Targets for chemotherapy of infections with anaerobic Protozoa rezistant to 5-nitroimidazoles (OC B9.10)

for therapy of nitroimidazole-resistant organisms. Drug resistance studies will focus activation process and on alternative metabolic pathways enhanced by the drug resistant targets for therapy of the

EE - Mikrobiologie, virologie

  • 1999 - 2002
    • •
  • 3 205 tis. Kč
    • •
  • 1 655 tis. Kč
    • •
  • MŠMT
Project

Method of drug form production, personalized to fit the needs of a specific patient using mathematical simulation and 3D printing (TJ02000383)

dissolution profile, is capable of producing a 3D drawing of a tablet (can also be multi-layered, multi-compartmentalised or contain multiple drugs), that will dissolve) and easy production of multi-drug ...

Pharmacology and pharmacy

  • 2019 - 2021
    • •
  • 4 099 tis. Kč
    • •
  • 3 398 tis. Kč
    • •
  • TA ČR
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