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416 (0,12s) •

Project

Mutants of tumor supressor protein p53 and regulation of thei DNA binding activity (KJB500040502)

repair, cell proliferation and apoptosis. Mutants of p53 protein are found in more than 50% ofcancer cases. Detailed study of p53 mutants, which are presented p53 mutant binding properties to natural binding sequences in l...

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 1 230 tis. Kč
    • •
  • 1 230 tis. Kč
    • •
  • AV ČR
Project

Different Dentition in Mutant and Non-mutant Strain of Mouse. (IAA7039503)

EB - Genetika a molekulární biologie

  • 1995 - 1997
    • •
  • 633 tis. Kč
    • •
  • 633 tis. Kč
    • •
  • AV ČR
Project

Detailed analyses of temperature-dependent mutants of the p53 tumor suppressor in human cells (NS10448)

We propose to perform detailed analysis of 23 temperature-dependent mutants of the p53 tumor suppressor in H1299 human cells to determine the level of temperature-dependency, discriminative character and susceptibility to reactivation by ami...

FD - Onkologie a hematologie

  • 2009 - 2011
    • •
  • 3 140 tis. Kč
    • •
  • 3 140 tis. Kč
    • •
  • MZ
Project

Generation of temperature sensitive cell division cycle mutants in green alga Chlamydomonas reinhardtii (GA204/09/0111)

of conditional cell division cycle mutants generated in 1970s by Leland Hartwell to generate a temperature sensitive cell division cycle mutants in the green alga are:1) produce temperature sensitive cell division cycle mutants...

EB - Genetika a molekulární biologie

  • 2009 - 2011
    • •
  • 2 492 tis. Kč
    • •
  • 2 492 tis. Kč
    • •
  • GA ČR
Project

ADAR RNA editing; how immune systems and brains breach The Central Dogma (GX21-27329X)

rescued Adar mutant mouse embryonic lethality in Adar1; Mavs double mutants will study changes in the glutamate receptors of Adar2 mutant mice that develop seizures. We will study changes in Adar2 as seizures progress in a...

Biochemistry and molecular biology

  • 2021 - 2025
    • •
  • 49 916 tis. Kč
    • •
  • 49 916 tis. Kč
    • •
  • GA ČR
Project

The chaperones and stress factors effect on folding and stability of the wild type and mutant cystathionine beta-synthase (CBS) (GP305/02/D167)

of given protein in a cell. The fate of the mutant proteins is result of competition isto study protein folding of normal and mutant CBS in E. coli and eukaryotic on biochemical properties and oligomeric structure of the wild type ...

EB - Genetika a molekulární biologie

  • 2002 - 2004
    • •
  • 580 tis. Kč
    • •
  • 580 tis. Kč
    • •
  • GA ČR
Project

Local DNA structures and their role in mutant p53 protein function in human tumours (GA22-21903S)

non-B DNA structures. Most missense p53 mutant proteins show reduced sequence. Differences in mutant p53 binding to structured DNAs are poorly understood. We will systematically study binding of common mutant p53s to local...

Oncology

  • 2022 - 2024
    • •
  • 7 056 tis. Kč
    • •
  • 7 056 tis. Kč
    • •
  • GA ČR
Project

The application of CRISPR-Cas9 for the creation of multiple mutants in the genes coding for the nascent polypeptide associated complex (LTC20050)

reproduction. Conventional Arabidopsis thaliana double homozygous mutant in the genes defects in the flowers and siliques. Moreover, seeds of the double homozygous mutant of this project is to employ modern genome editing technique...

Plant sciences, botany

  • 2020 - 2023
    • •
  • 4 863 tis. Kč
    • •
  • 4 863 tis. Kč
    • •
  • MŠMT
Project

Targeted protein degradation in plant hormone cytokinin responses (7AMB17AT027)

(1) Generation of new mutant lines. The CRISPR/Cas9 system for targeted mutagenesis shall be used to generate mutants in genes of ubiquitylation components. Primary goal is to generate mutants in genes AtUBC7, 15, 17, 22, 3...

CE - Biochemie

  • 2017 - 2018
    • •
  • 175 tis. Kč
    • •
  • 175 tis. Kč
    • •
  • MŠMT
Project

Characterization of the pollen phenotype of an Arabidopsis thaliana AtFH3 mutant (KJB600380601)

links both research fields, as the Arabidopsis formin mutant fh3 with disruption laboratory. I intend to characterize specific features of mutant plants and also and crosses of fh3 to other mutant or stably transformed lin...

EB - Genetika a molekulární biologie

  • 2006 - 2007
    • •
  • 517 tis. Kč
    • •
  • 517 tis. Kč
    • •
  • AV ČR
  • 1 - 10 out of 416