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548 (0,123s) •

Project

Mutants of tumor supressor protein p53 and regulation of thei DNA binding activity (KJB500040502)

repair, cell proliferation and apoptosis. Mutants of p53 protein are found in more than 50% ofcancer cases. Detailed study of p53 mutants, which are presented p53 mutant binding properties to nat...

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 1 230 tis. Kč
    • •
  • 1 230 tis. Kč
    • •
  • AV ČR
Project

Detailed analyses of temperature-dependent mutants of the p53 tumor suppressor in human cells (NS10448)

We propose to perform detailed analysis of 23 temperature-dependent mutants of the p53 tumor suppressor in H1299 human cells to determine the level of temperature-dependency, discriminative character and susceptibility to reactivati...

FD - Onkologie a hematologie

  • 2009 - 2011
    • •
  • 3 140 tis. Kč
    • •
  • 3 140 tis. Kč
    • •
  • MZ
Project

Local DNA structures and their role in mutant p53 protein function in human tumours (GA22-21903S)

non-B DNA structures. Most missense p53 mutant proteins show reduced sequence. Differences in mutant p53 binding to structured DNAs are poorly understood. We will systematically study binding of common mutant<...

Oncology

  • 2022 - 2024
    • •
  • 7 056 tis. Kč
    • •
  • 7 056 tis. Kč
    • •
  • GA ČR
Project

Functional analysis of temperature sensitive mutants of tumor suppressor p53 (NR8068)

In the submitted project we propose to analyze temperature and cold senzitive mutations of tumor suppressor p53. We intend to quantify the level of their temperature sensitivity, site-specific transactivation ability and level of reactivatio...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 2 015 tis. Kč
    • •
  • 1 946 tis. Kč
    • •
  • MZ
Project

Wild type and mutant p53 tumor suppressor protein. Intermolecular interactions, changes in conformation and new micro-methods of their analysis (IAA500040513)

of mutated p53, including DNA binding. Almost nothing is known about the mutant p53-specific binding of mutant p53 to scDNA will be investigated. In addition new chemicalThe tumor suppressor protein p...

CE - Biochemie

  • 2005 - 2008
    • •
  • 2 930 tis. Kč
    • •
  • 2 930 tis. Kč
    • •
  • AV ČR
Project

The role of p53 DNA structure-selective binding in brain cancer (GAP301/10/2370)

prognosis and dismal survival. Mutant p53 proteins acquire a -gain of function- activity to non-B DNA structures (DNA triplexes) in regulatory regions of mutant p53 target will identify new glioma markers on the b...

EB - Genetika a molekulární biologie

  • 2010 - 2012
    • •
  • 1 757 tis. Kč
    • •
  • 1 757 tis. Kč
    • •
  • GA ČR
Project

Molecular and cellular consequences of p53 manipulation using heat shock protein inhibitors and E3-ligases. (GA301/08/1468)

circumstances. Many p53 mutant proteins found in human tumours are stabilised compared on the inability of mutant p53 to induce MDM2. Using human tumour cells expressing wild-typep53, mutant 53 and p5...

FD - Onkologie a hematologie

  • 2008 - 2010
    • •
  • 3 063 tis. Kč
    • •
  • 2 925 tis. Kč
    • •
  • GA ČR
Project

Analysis of functional alterations of mutant forms of p53 protein in human cancers. (NC7131)

tumour cells expressing different mutant forms of p53 will be studied. Comprehensive will examine whether cell lines bearing a transcriptionally active mutant p53 can up analysis of the status of specific phosphor...

FD - Onkologie a hematologie

  • 2002 - 2004
    • •
  • 7 615 tis. Kč
    • •
  • 7 568 tis. Kč
    • •
  • MZ
Project

Interactions of wild type and mutant p53 proteins with damaged DNA and their roles in cellular response to anticancer chemotherapy (IAA500040701)

Interactions of tumor suppressor protein p53 with DNA are crucial for its biological activities. It was suggested that not only the wild type (wt) p53 sequence-specific DNA binding, but also ability of both wt and mutant (m...

EB - Genetika a molekulární biologie

  • 2007 - 2010
    • •
  • 4 824 tis. Kč
    • •
  • 4 824 tis. Kč
    • •
  • AV ČR
Project

Interactions of p53 protein and its homologues with DNA and their role in malignant transformation (GA301/02/0831)

of mutant p53 protein. Our project is focused towards biological, biochemical modifications of p53 protein and the response of cells carrying different mutant forms converge on p53. The ability of p53...

FD - Onkologie a hematologie

  • 2002 - 2004
    • •
  • 4 430 tis. Kč
    • •
  • 2 960 tis. Kč
    • •
  • GA ČR
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