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Projects

2 362 projects (0,112s)

Project

Phylogeography, selection and mutation rate at the whole-genome level Inference from mtDNA sequences of the house mouse (GA16-23773S)

and colonisation history of mtDNA haplotypes, their introgression across the HMHZ, rate of heteroplasmy, mutation rate, the role of selection, and phenotypic correlates are able to introgress across, which are susceptible ...

EG - Zoologie

  • 2016 - 2020
  • 9 979 tis. Kč
  • 9 685 tis. Kč
  • GA ČR
Project

Analysis of genetic background of Diamond-Blackfan anemia (GP301/04/P199)

ribosomal protein S19 (RPS19) has been found to be mutated in 25% of DBA patients. However, theinfluence of RPS19 mutations on DBA pathogenesis has not been elucidated function of mutated RPS19 in translation and/or 2) dis...

FD - Onkologie a hematologie

  • 2004 - 2005
  • 599 tis. Kč
  • 599 tis. Kč
  • GA ČR
Project

Improvement of the prevention of the most common chromosomal abberations and cystic fibrosis in the preimplantation phase of development. (NR7962)

of IVF success rates and prevention of these severe errors of prenatal and postnatal phase.Preimplantation screening (PGS) of chromosomal aberrations will improve IVF success rates diagnosis (PGD) of CF mutations will circ...

EB - Genetika a molekulární biologie

  • 2004 - 2006
  • 999 tis. Kč
  • 998 tis. Kč
  • MZ
Project

New molecular markers for monitoring of residual disease in acute myeloid leukemia patients (NS10632)

, mutation, and methylation in samples from AML patients. Evaluation of correlation of results of gene expression, mutation and methylation with the course of patients? treatment. The individualization of treatment and increased

FD - Onkologie a hematologie

  • 2009 - 2011
  • 7 576 tis. Kč
  • 7 576 tis. Kč
  • MZ
Project

Exploring the impact of somatic expansion rates on quantitative progression marker candidates (Voice) in early stages of Repeat Expansion Disorders (9F25002)

Aim 1: Identify and characterize molecularly a population of patients carrying repeat expansion mutations at early disease stages/prodromal (within 5 years, and somatic expansion index and somatic expansion rate Aim 2: Study longi...

Clinical neurology

  • 2025 - 2028
  • 6 206 tis. Kč
  • 6 206 tis. Kč
  • MŠMT
Project

Proteomic analysis of adaptive mutations in antibiotic resistant bacteria during long time cultivations (GA310/03/0292)

it starts to accumulate secondary adaptive mutations, which improve the fitness resistance stays. The aim of this project is to study these types of mutations continuous cultivation technologies to get closer to the low growth ...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 2003 - 2005
  • 2 296 tis. Kč
  • 2 296 tis. Kč
  • GA ČR
Project

The identification and the characterization of the leukemia-inhibitory factor gene mutations in the population of women with idiopathic infertility (GA301/02/1232)

low pregnancy rates of routinely used assisted reproduction techniques. The key failure. Our experiments will focus on mutations that can result in the decreased LIF spontaneously. LIF gene mutations will be identified usi...

FK - Gynekologie a porodnictví

  • 2002 - 2004
  • 1 700 tis. Kč
  • 1 700 tis. Kč
  • GA ČR
Project

Genetic screening of patients with Hirschsprung´s disease in the Czech Republic (GP301/06/P425)

%) or hereditary forms (25%). Germ-line mutations in the RET proto-oncogene (10q11.2) are found along the whole gene, where the detection rate is totally 20% and in familiar form of positive samples to detect germ-line mutations...

EB - Genetika a molekulární biologie

  • 2006 - 2008
  • 1 192 tis. Kč
  • 1 192 tis. Kč
  • GA ČR
Project

The prevalence of thrombophilias in women with abruptio placentae. (NH6986)

The assesment of the incidence of the thrombophilic disorders in women with placental abruption. The observe thrombophilic markrs are Leiden mutation of the factor V. clotting cascade, mutation of MTHFR methylentetrahydrofolatreduct...

FK - Gynekologie a porodnictví

  • 2002 - 2004
  • 1 841 tis. Kč
  • 1 837 tis. Kč
  • MZ
Project

The influence of thrombophilic factors to the risk of postoperative venous thromboembolism (VTE) in patients indicated for elective surgery for cancer in the abdominal cavity. (NT13251)

thrombophilias (1691 G> A) and F II 20210 G> A mutations (with prevalence of heterozygote of tumorous process as well, including the survival rate of carcinoma patients. Results risk rate in patients operated for GIT carci...

FJ - Chirurgie včetně transplantologie

  • 2012 - 2015
  • 8 129 tis. Kč
  • 8 129 tis. Kč
  • MZ
  • 1 - 10 out of 2 362