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1 935 (0,061s) •

Project

Promoter methylation analysis of the genes downstream of BRCA1 and BRCA1 - comparison of methylation profiles in mutation carriers and non-carriers (GP301/08/P103)

time.The expression profile difference of BRCA1/2 mutation carriers allows to formulate hypothesis: There is a specific methylation profiles in BRCA1/2 mutation carriersDifferent penetrance of identical mutati...

EB - Genetika a molekulární biologie

  • 2008 - 2010
    • •
  • 1 563 tis. Kč
    • •
  • 1 563 tis. Kč
    • •
  • GA ČR
Project

Development and clinical utility of a new method to identify patients with risk of recurrent colorectal lesions and personalization of their surveillance based on mutation burden and clinical (NU22-08-00424)

and 5 years. Moreover, the mutation profile of all metachronous lesions developed is dependent on the appearance of somatic mutations in protooncogenes and tumor suppressor genes. Based on our previous mutation an...

Gastroenterology and hepatology

  • 2022 - 2025
    • •
  • 14 142 tis. Kč
    • •
  • 12 682 tis. Kč
    • •
  • MZ
Project

The relationship of the androgen receptor gene mutations and changes in the androgen receptor expression in prostate cancer to the biological properties of the tumor and to the hormonal profile (NR8096)

The project is focused on the determination of the relationship of the androgen receptor gene mutations and changes in the AR expression in localized prostate cancer parameters will be compared mutually and related to the hormonal profil...

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 3 119 tis. Kč
    • •
  • 3 110 tis. Kč
    • •
  • MZ
Project

Introducing a testing of somatic mutations in hematopoietic cells (EG16_083/0010326)

The subject of the present project is the introduction of somatic mutations in haematopoietic cells, ie assembling a functional diagnostic test to identify mutations. A product will be created to provide clients with a profile

EB - Genetika a molekulární biologie

  • 2017 - 2020
    • •
  • 31 063 tis. Kč
    • •
  • 1 412 tis. Kč
    • •
  • MPO
Project

Identification and monitoring of prognostic and predictive molecular markers in patients with low risk myelodysplastic syndrome (NV18-03-00227)

of specific mutations at the time of diagnosis in patients with low risk MDS that would predict the disease progression. We will perform a mutational screening will carry out a prospective mutational study in patients with...

Oncology

  • 2018 - 2022
    • •
  • 9 087 tis. Kč
    • •
  • 8 090 tis. Kč
    • •
  • MZ
Project

Genome-wide expression profiling and mutation analysis as the diagnostic basis for personalized pediatric cancer treatment plans a feasibility study (NV16-33209A)

the clinical applicability and feasibility of gene expression and mutational data to drive expression and mutational data to design innovative personalized therapi.........

FD - Onkologie a hematologie

  • 2016 - 2019
    • •
  • 15 042 tis. Kč
    • •
  • 15 042 tis. Kč
    • •
  • MZ
Project

Development of a New Generation Multiparametric Test for Prediction of Colorectal Neoplasia Recurrence (NV17-31909A)

profiles of highly frequent mutated genes (KRAS, TP53, PIK3CA and APC) will be done somatic mutations profiling will be carried out according to multitarget sequencing of mutations (score of heterogenity ...

FE - Ostatní obory vnitřního lékařství

  • 2017 - 2021
    • •
  • 14 888 tis. Kč
    • •
  • 13 294 tis. Kč
    • •
  • MZ
Project

Genes influencing limb patterning morphology and functional genomics of hypodactyly and polydactyly-luxate mutations in the Norway rat (GA304/06/0116)

Spontaneous mutations in model organisms were proven as important tools anddevelopmental analysis of mutations causing limb malformations - hypodactyly (hd for the role of the studied mutations in limb patterning is propose...

EA - Morfologické obory a cytologie

  • 2006 - 2008
    • •
  • 4 826 tis. Kč
    • •
  • 4 772 tis. Kč
    • •
  • GA ČR
Project

Positional cloning of rat hypodactyly - a mutation causing male infertility and limb deformity (GA301/02/0464)

Hypodactyly (Hd) is autosomal recessive mutation afflicting both spermatogenesis and limb development, mapped to chromosome 10 of the rat. Function profiles in Hd carriers will be determined and putative candidate genes will be scre...

EB - Genetika a molekulární biologie

  • 2002 - 2004
    • •
  • 1 970 tis. Kč
    • •
  • 1 970 tis. Kč
    • •
  • GA ČR
Project

Molecular classification in relation to prevention of endometrial cancer recurrence and lifestyle factors (NW24-09-00505)

analysis of dominant mutational profiles associated with a specific molecular subtype relationship of the mutational profile with the extent of staging lymphadenectomy may help with genomic mutational sig...

Human genetics

  • 2024 - 2027
    • •
  • 11 560 tis. Kč
    • •
  • 11 227 tis. Kč
    • •
  • MZ
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