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731 (0,199s) •

Project

The prevalence of thrombophilias in women with abruptio placentae. (NH6986)

The assesment of the incidence of the thrombophilic disorders in women with placental abruption. The observe thrombophilic markrs are Leiden mutation of the factor V. clotting cascade, mutation of MTHFR methylentetrahydrofolatreduct...

FK - Gynekologie a porodnictví

  • 2002 - 2004
    • •
  • 1 841 tis. Kč
    • •
  • 1 837 tis. Kč
    • •
  • MZ
Project

Clinical significance and electrophysiological evaluation of KCNQ1 gene mutation c.926C>T (p.T309I) as a possible long QT syndrome founder mutation (NV16-30571A)

Mutations in genes encoding cardiac ionic channels and related proteins characterized by its own mutation; the same mutation found in unrelated families living in the same region may represent the founder mutation....

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2016 - 2020
    • •
  • 10 413 tis. Kč
    • •
  • 10 381 tis. Kč
    • •
  • MZ
Project

Prevalence of known mutations and search for new gene mutations and polymorphisms in patients with MODY diabetes in the Czech Republic. (NB6122)

Known mutations will be estimated and new mutations and polymorphisms will be searched in 5 genes responsible for MODY diabetes by direct gene sequencing. Consequently, genotype-phenotype correlation based on clinical and laboratory...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2000 - 2002
    • •
  • 2 615 tis. Kč
    • •
  • 2 613 tis. Kč
    • •
  • MZ
Project

Introducing a testing of somatic mutations in hematopoietic cells (EG16_083/0010326)

The subject of the present project is the introduction of somatic mutations in haematopoietic cells, ie assembling a functional diagnostic test to identify mutations in selected sections of human DNA, including the development of an...

EB - Genetika a molekulární biologie

  • 2017 - 2020
    • •
  • 31 063 tis. Kč
    • •
  • 1 412 tis. Kč
    • •
  • MPO
Project

Intermittent androgen blockade abd androgen receptor mutation (NR7798)

Mechanism why intermittent androgen blockade selects androgen receptor mutations and why regaing sensitivity to therapy is only temporary will be researched. Whether androgen receptor mutations are responsible for progression to hor...

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 478 tis. Kč
    • •
  • 398 tis. Kč
    • •
  • MZ
Project

Trihetromeric NMDA receptors - physiological and pathophysiological functional properties (LTAUSA19122)

mutations. The project focuses mainly on the analysis of the effect of previously unexplored mutations on NMDAR physiology, the evaluation of the significance of mutations when incorporated in the native triheteromeric NMD...

Neurosciences (including psychophysiology)

  • 2020 - 2022
    • •
  • 5 396 tis. Kč
    • •
  • 5 396 tis. Kč
    • •
  • MŠMT
Project

Explaining metastatic potential of colorectal cancer through whole-exome sequening and immune cell and telomere landscape (GA23-05609S)

sequencing (WES). We search for critical mutations and mutation signatures that are associated with the metastatic process. Numbers of mutations (tumor mutation burden of mutations, mutation sign...

Oncology

  • 2023 - 2025
    • •
  • 12 109 tis. Kč
    • •
  • 12 109 tis. Kč
    • •
  • GA ČR
Project

Molecular analysis of the APC and MYH genes in families affected with familial adenomatous polyposis or multiple adenomas (NR8103)

Genetic causes of FAP, AFAP and multiple adenomas in the selected set of families with no demonstrable germline APC mutation. Analysis of invisible germline APC mutations and of germline MYH mutations. Mutation ana...

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 2 846 tis. Kč
    • •
  • 2 810 tis. Kč
    • •
  • MZ
Project

Early identification of CLL patients with yet unselected p53 mutation (NT13519)

Mutations in p53 are associated with particularly poor prognosis in chronic lymphocytic leukemia. These harmful mutations are frequently selected by conventional technology with the extreme sensitivity of mutation detection...

FD - Onkologie a hematologie

  • 2012 - 2015
    • •
  • 7 745 tis. Kč
    • •
  • 7 745 tis. Kč
    • •
  • MZ
Project

Analysis of plant gene regulation systems by constitutive gene activation (GA204/97/0154)

will beused. Three types of mutations will be scored in the offspring: 1. Flower morphoregulatory mutations. 2. Toot morphoregulatory mutations. 3. Mutations with increased sensitivity to mutagens. New mutatio...

EB - Genetika a molekulární biologie

  • 1997 - 1999
    • •
  • 4 900 tis. Kč
    • •
  • 3 042 tis. Kč
    • •
  • GA ČR
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