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42 (0,064s) •

Project

The expression of proinflammatory genes in patients with IgA nephropathy and their relation to the disease outcome (NR8913)

Determine correlation among intrarenal expression of MCP-1, RANTES, TGF-beta1, HGF and BMP genes, infiltration of leukocyte into renal tissue, proteinuria and short term otcome of IgA nephropathy. Find out if patients with genotype related a...

FE - Ostatní obory vnitřního lékařství

  • 2006 - 2009
    • •
  • 4 966 tis. Kč
    • •
  • 4 432 tis. Kč
    • •
  • MZ
Project

The role of vasoactive humoral systems in pathogenesis of diabetic nephropathy. (NB6365)

The aims of the project are a) to test the regulation of selected vasoactive humoral systems and their role in the pathogenesis of diabetic nephropathy in type I diabetic patients and healthy subjects and b) to evalute the possibilities of r...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2000 - 2002
    • •
  • 6 135 tis. Kč
    • •
  • 6 135 tis. Kč
    • •
  • MZ
Project

Cyclooxygenase-2 polymorphisms and the development of nephropathy in diabetes (NR9368)

Using molecular biological techniques we will study -765GC polymorphisms in COX-2 gene and their possible impact on monocytic COX-2 phenotype in diabetic patients with nephropathy in comparison with patients without DN and healthy subjects.....

EB - Genetika a molekulární biologie

  • 2007 - 2010
    • •
  • 3 446 tis. Kč
    • •
  • 3 386 tis. Kč
    • •
  • MZ
Project

Genetic variability of pentose phosphate pathway as a modulating factor of the onset and progression of diabetic nephropathy (NR9443)

The project aims to optimise early diagnostics of diabetic nephropathy by means of genetic analysis of transketolase and transaldolase genes and to allow individualised follow-up of diabetics and, eventually, even individualised therapeutic ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2007 - 2009
    • •
  • 3 846 tis. Kč
    • •
  • 3 846 tis. Kč
    • •
  • MZ
Project

Factors affecting the course of IgA nephropathy – the most common primary glomerulonephritis. (LH15168)

We propose to develop noninvasive diagnostic tests for detection of subclinical types of IgA nephropathy, evaluation of disease activity, and assessment of treatment effectiveness. Consequently, these tests will allow to avoid repeat renal b...

EB - Genetika a molekulární biologie

  • 2015 - 2017
    • •
  • 1 896 tis. Kč
    • •
  • 1 896 tis. Kč
    • •
  • MŠMT
Project

New mode of treatment of IgA nephropathy and the ways of monitoring (IZ4216)

The evaluation of the role of prostanoids in treatment of IgA nephropathy using fish oil is the main target of the project.During the one year s treatment with fish oil levels of prostanoids and cytokines will be monitored.......

FE - Ostatní obory vnitřního lékařství

  • 1997 - 1999
    • •
  • 1 841 tis. Kč
    • •
  • 1 620 tis. Kč
    • •
  • MZ
Project

Molecular basis of familial juvenile hyperuricemic nephropathy (NE7046)

Combination of positional cloning and functional genomics approaches will help in elucidation of molecular basis of familial juvenile hyperuricemic nephropathy. This enable correct pre-clinical DNA diagnostic which is vital for efficient tre...

EB - Genetika a molekulární biologie

  • 2002 - 2004
    • •
  • 7 179 tis. Kč
    • •
  • 7 174 tis. Kč
    • •
  • MZ
Project

Study on participation of biotransformation enzymes in development of renal injury and urothelial cancer mediated by aristolochic acid (GA303/09/0472)

Ingestion of aristolochic acid I (AAI) is associated with the development of AAI nephropathy (AAN), which is characterized by chronic renal failure, tubulointestitial fibrosis and urothelial cancer. AAI may also cause a similar type of kidne...

CE - Biochemie

  • 2009 - 2013
    • •
  • 2 892 tis. Kč
    • •
  • 2 892 tis. Kč
    • •
  • GA ČR
Project

The study of interactions among IgA1-glycosylating enzymes in IgA nephropathy (LH11046)

Abnormalities in immunoglobulin A1 (IgA1) O-linked glycosylation belong to the initial cause of IgA nephropathy. Several enzymes-glycosyltransferases (GTs) namely ST6GalNAcII, C1GalT1, C1GalT2, and GalNAcT2 contribute in IgA1 O-glycosylation...

EC - Imunologie

  • 2011 - 2014
    • •
  • 1 822 tis. Kč
    • •
  • 1 822 tis. Kč
    • •
  • MŠMT
Project

Possibilities of diabetic nephropathy modification and prevention of renal failure progression in diabetics. (IZ932)

9F - 9

  • 1992 - 1995
    • •
  • 235 tis. Kč
    • •
  • 470 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 42