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Projects
New Methods for Determination of Neuroactive Steroids and Their Polar Conjugates in Human Tissues and Serum (NR7768)
We intend to develop new high sensitive and selective methods for determination of neuroactive pregnanolone isomers by means of gass chromatgraphy with mass spectrometry (GC-MS) with new derivatization techniques. The new quick and sensitive...
FB - Endokrinologie, diabetologie, metabolismus, výživa
- 2004 - 2006 •
- 4 691 tis. Kč •
- 4 194 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2004 - 1. 1. 2006
Uznané náklady
Podpora ze státního rozpočtu (89%)
Poskytovatel: Ministerstvo zdravotnictví
To the role of neuroactive steroids Their metabolism and its influencing under physiological and pathological conditions (NB6702)
The proposed grant is studying the interactions between the levels of neuroactive steroids and homocysteine in physiological and pathological conditions and the influence of exogenous and endogenous factors on the activity of steroi...
FB - Endokrinologie, diabetologie, metabolismus, výživa
- 2001 - 2003 •
- 2 262 tis. Kč •
- 1 956 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2001 - 1. 1. 2003
Uznané náklady
Podpora ze státního rozpočtu (86%)
Poskytovatel: Ministerstvo zdravotnictví
The smoking cessation and hormonal homeostasis oriented to neuroactive steroids (NS10215)
enzyme of the synthesis of neuroactive steroids. We shall focus on the influence of smoking on the synthesis of neuroprotective and immunomodulating 7-hydroxy-steroids. We will map the metabolism of steroids in th...
FB - Endokrinologie, diabetologie, metabolismus, výživa
- 2009 - 2011 •
- 4 441 tis. Kč •
- 4 441 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2009 - 31. 12. 2011
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
Evaluation of the biosynthesis and transport of neuroactive steroids in the central nervous system and periphery (NR9157)
The aim is to find key steps of biosynthesis and uptake of neuroactive- and related steroids in CNS following their levels in serum, CSF and fluids from the brain ventricles in 60 hydrocephalic patients using GC-MS and multivariate ...
FB - Endokrinologie, diabetologie, metabolismus, výživa
- 2007 - 2009 •
- 3 678 tis. Kč •
- 3 593 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2007 - 31. 12. 2009
Uznané náklady
Podpora ze státního rozpočtu (98%)
Poskytovatel: Ministerstvo zdravotnictví
The role of neuroactive steroids and other hormonal parameters in diagnostics and treatment of schizofrenia (NS9835)
Schizofrenia represents a serious disease, with a high risk of suicide. To biochemical factors affecting its origination and development belong neuroactive steroids parameters, to give reasons for neuroactive steroid
FB - Endokrinologie, diabetologie, metabolismus, výživa
- 2008 - 2011 •
- 8 222 tis. Kč •
- 8 222 tis. Kč •
- MZ
Řešení projektu: 1. 7. 2008 - 31. 12. 2011
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
Influence of smoking and its cessation on endocrine system (NR9055)
In common steroids, the effect of smoking was investigated but in neuroactive steroids there are a nuber of metabolic pathawas that were not examined. Nicotine participating ina synthesis of neuroactive progesteron...
FB - Endokrinologie, diabetologie, metabolismus, výživa
- 2006 - 2009 •
- 6 948 tis. Kč •
- 6 380 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2006 - 31. 12. 2009
Uznané náklady
Podpora ze státního rozpočtu (92%)
Poskytovatel: Ministerstvo zdravotnictví
Alcohol and neuroactive steroids. (NB6891)
Some information indicating the relation between neuroactive steroids and the mechanism of alcohol action in rodents are available while in humans such knowledge is limited. We intend to evaluate the levels of steroid activ...
FB - Endokrinologie, diabetologie, metabolismus, výživa
- 2002 - 2004 •
- 5 195 tis. Kč •
- 4 937 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2002 - 1. 1. 2004
Uznané náklady
Podpora ze státního rozpočtu (95%)
Poskytovatel: Ministerstvo zdravotnictví
Neuroactive steroids in male reproduction (1A8235)
The aim of the project is the study of the participation of neuroactive steroids (pregnenolone and isomers of pregnanolone) in the course of the male orgasm and ejaculation as a basis of potential treatment of their disturbances.......
FB - Endokrinologie, diabetologie, metabolismus, výživa
- 2004 - 2006 •
- 1 331 tis. Kč •
- 1 287 tis. Kč •
- MZ
Řešení projektu: 1. 1. 2004 - 1. 1. 2006
Uznané náklady
Podpora ze státního rozpočtu (97%)
Poskytovatel: Ministerstvo zdravotnictví
The Synthesis of Water-soluble Derivative of Neuroactive Steroids and Evaluation of Their Neuropsychotropic Activity (NL4668)
Water-soluble derivatives of neuroactive steroids will be synthesized and their anxiolytic,sedative and other neuropsychotropic activities will be tested in animalis. The structure of the steroids will be modified in order ...
FR - Farmakologie a lékárnická chemie
- 1998 - 2000 •
- 2 317 tis. Kč •
- 1 460 tis. Kč •
- MZ
Řešení projektu: 1. 1. 1998 - 1. 1. 2000
Uznané náklady
Podpora ze státního rozpočtu (63%)
Poskytovatel: Ministerstvo zdravotnictví
Neuroactive steroids in diagnostics of postpartum mental disorders (NS9790)
sources of CRH and sex and neuroactive steroids (NS) in pregnancy as well hormones, sex and neuroactive steroids in relation to the occurrence and intensity......
FB - Endokrinologie, diabetologie, metabolismus, výživa
- 2008 - 2011 •
- 5 141 tis. Kč •
- 5 141 tis. Kč •
- MZ
Řešení projektu: 1. 7. 2008 - 31. 12. 2011
Uznané náklady
Podpora ze státního rozpočtu (100%)
Poskytovatel: Ministerstvo zdravotnictví
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