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Project

Mechanisms of Neuropathic Pain States (LH12058)

The aim of this project proposal is to study the influence of synaptic transmission modulation of nociceptive signalling at the spinal cord level in neuropathic pain states. Neuropathic conditions will be studied using models of per...

FH - Neurologie, neurochirurgie, neurovědy

  • 2012 - 2015
    • •
  • 3 546 tis. Kč
    • •
  • 3 382 tis. Kč
    • •
  • MŠMT
Project

Specific characteristics of neuropathic pain of central and peripheral type (NT13523)

The project is focused on the extension of the knowledge about pathophysiology of various types of neuropathic pain, in particular central neuropathic pain in multiple sclerosis and combined pain of nociceptive and peripheral ne...

FH - Neurologie, neurochirurgie, neurovědy

  • 2012 - 2015
    • •
  • 5 723 tis. Kč
    • •
  • 5 723 tis. Kč
    • •
  • MZ
Project

Mechanisms of neuropathic pain. (LUAUS25275)

The main goal of this project is to study the mechanisms of neuropathic pain implications for the development of neuropathic pain conditions in patients, where subjects and after induction of neuropathic pain in neuropathy ...

Neurosciences (including psychophysiology)

  • 2025 - 2028
    • •
  • 8 179 tis. Kč
    • •
  • 8 179 tis. Kč
    • •
  • MŠMT
Project

Neuroinflammation in development of pain (GA24-10712S)

Chronic painful conditions, especially of neuropathic origin are serious diseases that significantly limit patients by attacks of spontaneous pain and pain preliminary results show their important influence on the development of neuropat...

Neurosciences (including psychophysiology)

  • 2024 - 2026
    • •
  • 6 987 tis. Kč
    • •
  • 6 864 tis. Kč
    • •
  • GA ČR
Project

Gene therapy of neuropathic pain and spasticity via subpial application of AAV vectors in area of spinal cord roots of sciatic nerve and spinal cord injury in minipigs (LTAUSA19029)

Understanding the molecular mechanisms of chronic neuropathic pain and muscle design and preparation) and neurosurgery (creation of chronic neuropathic pain in ameliorating symptoms of neuropathic pain and muscle spasticity...

Neurosciences (including psychophysiology)

  • 2020 - 2023
    • •
  • 11 385 tis. Kč
    • •
  • 11 385 tis. Kč
    • •
  • MŠMT
Project

Sacral Anterior Root Stimulators for Neuropathic Urinary Bladder Control (ND5757)

Anterior sacral roots stimulation coupled with posterior rhizotomy is a new treatment modality of neuropathic bladder in spinal cord injury patients with intact reflex arc. Midthoracic complete paraplegics, especially women, benefit most fro...

FH - Neurologie, neurochirurgie, neurovědy

  • 1999 - 2001
    • •
  • 3 812 tis. Kč
    • •
  • 3 758 tis. Kč
    • •
  • MZ
Project

The role of cytokines and chemokines in the nociceptive signaling (GPP303/12/P510)

One of the actual challenges in pain research is neuropathic pain, which is the most difficult type of chronic pain to treat. Enhanced cytokine production is increasingly recognized as crucial element in nociceptive processing at spinal cord...

ED - Fyziologie

  • 2012 - 2014
    • •
  • 2 619 tis. Kč
    • •
  • 2 619 tis. Kč
    • •
  • GA ČR
Project

Antinociceptive mechanisms of motor cortex stimulation. (NF7406)

The subject of the project is to discover antinociceptive mechanisms of motor cortex stimulation (MCS). Effects of different parameters of MCS on spontaneous and evoked pain and tactile sensation will be investigated in man. After an expected verific...

FH - Neurologie, neurochirurgie, neurovědy

  • 2003 - 2005
    • •
  • 1 204 tis. Kč
    • •
  • 1 184 tis. Kč
    • •
  • MZ
Project

Spatio-temporal changes of cytokines in the dorsal root ganglia of experimental neuropathic pain models induced by unilateral nerve injury (GA309/07/0121)

Peripheral nerve injury results in the peripheral neuropathic pain. However, the pathophysiological mechanisms involved in the origin of mechanoallodynia and thermal hyperalgesia remain poorly understood. The cellular and molecular changes i...

FH - Neurologie, neurochirurgie, neurovědy

  • 2007 - 2009
    • •
  • 3 231 tis. Kč
    • •
  • 3 231 tis. Kč
    • •
  • GA ČR
Project

The role of spinal inhibitory neurons in the development of painful states. (GA20-19136S)

Chronic and neuropathic pain conditions are often characterized by attacks of spontaneous pain and allodynia. The treatments available are not effective and accompanied by serious side effects. In order to develop new effective analgesic tre...

Neurosciences (including psychophysiology)

  • 2020 - 2022
    • •
  • 6 209 tis. Kč
    • •
  • 6 209 tis. Kč
    • •
  • GA ČR
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