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23 (0,112s) •

Project

Overlap of neurodegenerative dementias and their clinic-pathological correlations a prospective-retrospective multicentric study (NV19-04-00090)

in many patients.Moreover,newly described neuropathological entities related and in a neuropathological reference laboratory based on retrospective and prospective clinic......

Clinical neurology

  • 2019 - 2022
    • •
  • 14 989 tis. Kč
    • •
  • 14 928 tis. Kč
    • •
  • MZ
Project

Refractory focal epilepsy with normal MRI finding Analysis of etiopathogenesis and evaluation of individual preoperative diagnostic techniques (NR8843)

will be identified. By correlation with neuropathological findings, we will evaluate the potency...

FH - Neurologie, neurochirurgie, neurovědy

  • 2006 - 2009
    • •
  • 6 537 tis. Kč
    • •
  • 6 285 tis. Kč
    • •
  • MZ
Project

Neuropathological analysis of human epileptic brain tissue correlation with proton magnetic resonance spectroscopy. (NF7411)

a Findings of neuropathological analysis will be correlated with presurgical MR...

FH - Neurologie, neurochirurgie, neurovědy

  • 2003 - 2005
    • •
  • 4 304 tis. Kč
    • •
  • 3 970 tis. Kč
    • •
  • MZ
Project

Proton Magnetic Resonance Spectroscopy Correlation with Neuropathological Findings in Patients with Mesial Temporal Lobe Epilepsy (GP309/02/D076)

correlation of 1H MRS findings with both clinical data and detailed neuropathological...

FH - Neurologie, neurochirurgie, neurovědy

  • 2002 - 2005
    • •
  • 846 tis. Kč
    • •
  • 846 tis. Kč
    • •
  • GA ČR
Project

The source of neurological pathology in PNKP-mutated disease (GN23-07330I)

Hereditary mutations in the DNA strand break repair protein polynucleotide kinase-phosphatase (PNKP) result in a spectrum of neuropathologies, ranging from mild neurodegeneration to severe neurodevelopmental dysfunction. PNKP is implicated i...

Genetics and heredity (medical genetics to be 3)

  • 2023 - 2025
    • •
  • 5 499 tis. Kč
    • •
  • 5 499 tis. Kč
    • •
  • GA ČR
Project

Spatiotemporal transcriptome and proteome analysis of α-Synuclein pathology in Parkinson’s disease Identification of cell type-specific vulnerability and tolerance mechanisms (9F24003)

and integration with clinical, neuropathological, and genomic (e.g., GBA and HLA-R genetic...

Other medical science

  • 2024 - 2027
    • •
  • 6 633 tis. Kč
    • •
  • 6 633 tis. Kč
    • •
  • MŠMT
Project

Modulation of enzymatic activity in cathepsins (IAA4055303)

Failure to control lysosomal proteases (cathepsins) activity leads to pathological conditions. This project focuses on cathepsin C (modulator of immunocompetent cells) and cathepsin D (involved in breast cancer and neuropathology) and invest...

CE - Biochemie

  • 2003 - 2005
    • •
  • 2 427 tis. Kč
    • •
  • 889 tis. Kč
    • •
  • AV ČR
Project

Multidisciplinary approach in the diagnosis of frontotemporal lobar degenerations and tauopathies new insights into pathogenetic mechanisms (NT12094)

neuropathological examination will allow us to confirm the clinical diagnosis and follow...

FH - Neurologie, neurochirurgie, neurovědy

  • 2011 - 2015
    • •
  • 10 440 tis. Kč
    • •
  • 10 440 tis. Kč
    • •
  • MZ
Project

Damage of interneurons within the hippocampus and dentate gyrus after status epilepticus in developing rats (GA304/04/0464)

Temporal lobe epilepsy represents majority of therapy-resistant epilepsies in patients. Many cases start during childhood. This epilepsy is characterized morphologically by hippocampanal sclerosis affecting mostly dentate gyrus and hippocampal fields...

EA - Morfologické obory a cytologie

  • 2004 - 2006
    • •
  • 2 715 tis. Kč
    • •
  • 2 715 tis. Kč
    • •
  • GA ČR
Project

Characterization of the first mouse model of mucopolysaccharidosis type IIIC (NT13122)

, 5, 10 month of age and at death, with special emphasis on neuropathology. Levels...

FG - Pediatrie

  • 2012 - 2015
    • •
  • 5 093 tis. Kč
    • •
  • 5 092 tis. Kč
    • •
  • MZ
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