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45 (0,064s) •

Project

Neurohistological changes of brain edema after the intracarotic administration of neuroprotective substances through the opened blood-brain barrier in experimental model in vivo and perspectives (ND6973)

Neurohistological changes of brain edema after the intracarotic administration of neuroprotective substances through the opened blood-brain barrier in experimental model in vivo and perspectives of neuroprotection in neurosurgery......

FH - Neurologie, neurochirurgie, neurovědy

  • 2002 - 2004
    • •
  • 1 057 tis. Kč
    • •
  • 960 tis. Kč
    • •
  • MZ
Project

The effect of cell membrane fluidity on the functional properties of NMDA receptors (GPP303/11/P391)

of cholesterol contents in plasma membrane of neurons has neuroprotective effect against NMDA definitely a neuroprotective effect; however, it does not exclude that other neuroprotective mechanisms are also involved. There...

ED - Fyziologie

  • 2011 - 2015
    • •
  • 2 195 tis. Kč
    • •
  • 2 195 tis. Kč
    • •
  • GA ČR
Project

Synaptic Effects and Neuroprotective Properties of NMDA Receptor-Modulating Neurosteroids (GJ16-03913Y)

receptors plays a key role in synaptic plasticity and can be neuroprotective. This paradoxical involvement of NMDARs in both neuroprotection and neurotoxicity motivates activated NMDARs and thus be neuroprotective. We wi...

ED - Fyziologie

  • 2016 - 2020
    • •
  • 4 509 tis. Kč
    • •
  • 4 509 tis. Kč
    • •
  • GA ČR
Project

Metabolomic and functional effects of 3α5β neuroactive steroids in perinatal brain damage (GA23-05746S)

and represent an attractive topic in pharmacology. The levels of neuroprotective NAS such as pregnenolone glutamate, hemisuccinate, and hemipimelate are non-toxic neuroprotective on the mechanism of neuroprotective effects...

Biochemical research methods

  • 2023 - 2025
    • •
  • 13 178 tis. Kč
    • •
  • 13 178 tis. Kč
    • •
  • GA ČR
Project

Structure-activity study and mechanism of action of analogues of humanin, a novel neuroprotective petide (ME 872)

understanding of humanine, new peptide biological function, its modification, development of new drugs...

CC - Organická chemie

  • 2006 - 2007
    • •
  • 180 tis. Kč
    • •
  • 180 tis. Kč
    • •
  • MŠMT
Project

Interaction of 7-methoxytacrine and galanthamine with potential neuroprotective agents (NL6091)

Experimental determinantion of anticholinesterase ctivity,principal pharmacokinetics,and hepatotoxicity of the cognitive drugs 7-methoxytacrine and galanthamine. Testing of their interaction with L-carnitine,acetyl L.carnitine,cyclosporine A and nimo...

FR - Farmakologie a lékárnická chemie

  • 2000 - 2002
    • •
  • 1 617 tis. Kč
    • •
  • 1 617 tis. Kč
    • •
  • MZ
Project

Novel neuroprotective compounds based on NMDA receptor antagonism and cholinergic stimulation (GA20-12047S)

is giving us also a tool for designing even more effective neuroprotectants. Therefore the real neuroprotective and pro-cognitive value rising from the dual character......

Medicinal chemistry

  • 2020 - 2022
    • •
  • 14 855 tis. Kč
    • •
  • 14 689 tis. Kč
    • •
  • GA ČR
Project

Analogues of insulin, IGF-1 and IGF-2 to study their neuroprotective effects in neurons and glial cells. (GA22-17978S)

basal and neuroprotective effects of several unique insulin, IGF-1 and IGF-2 provide some beneficial effects on neuroprotectivity of neurons and glial cells......

Cell biology

  • 2022 - 2024
    • •
  • 9 928 tis. Kč
    • •
  • 9 017 tis. Kč
    • •
  • GA ČR
Project

Mechanisms of Neuroprotective Action of FTO Inhibitors in Brain Mitochondrial Impairment and Alzheimer’s Disease (GA25-17745S)

. This project aims to elucidate the mechanisms of FTO inhibitor-induced neuroprotection to probe the hypothesis that the in vivo neuroprotective effects of FTO inhibitors......

Neurosciences (including psychophysiology)

  • 2025 - 2027
    • •
  • 8 139 tis. Kč
    • •
  • 8 139 tis. Kč
    • •
  • GA ČR
Project

Synthesis and study of properties of neuroprotective peptide analogues derived of humanin (GA305/03/1100)

a new neuroprotective peptide humanin was discovered, isolated knowledge of humanin and humanin like peptides as neuroprotective substances guarding......

FH - Neurologie, neurochirurgie, neurovědy

  • 2003 - 2005
    • •
  • 6 654 tis. Kč
    • •
  • 3 216 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 45