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793 (0,183s) •

Project

The control of viremia by neutralizing antibodies and localization of neutralization epitopes of porcine circovirus 2 (GA524/06/1640)

, that the titre of neutralizing antibodies influences the level of viremia in PCV-2 infected piglets. Viremia and the titer of neutralizing antibodies will be quantified. Additional objective of this study is to e...

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 2006 - 2008
    • •
  • 1 825 tis. Kč
    • •
  • 1 825 tis. Kč
    • •
  • GA ČR
Project

High-affinity protein binders of hepatitis C virus broadly-neutralizing antibodies as a base for preventative vaccine (NU23-05-00203)

of neutralizing antibodies. E1/E2 is extremely variable hindering straightforward development of effective protective vaccine inducing antibodies neutralizing broad spectrum of HCV antibodies neutrali...

Immunology

  • 2023 - 2026
    • •
  • 13 783 tis. Kč
    • •
  • 13 783 tis. Kč
    • •
  • MZ
Project

Detection of neutralizing antibodies against interferon beta in patients with Multiple Sclerosis (MS) treated by interferon beta 1-a and beta 1-b. Clinical and pharmacoeconomical importance. (NR9445)

Annotation I: Establishing the method of detection of neutralizing antibodies against IFN-ß using cythopathic effect method. Annotation II: Inclusion of all patients treated by IFN-ß in MS centre FH Motol, detection and monitoring o...

FH - Neurologie, neurochirurgie, neurovědy

  • 2007 - 2009
    • •
  • 3 760 tis. Kč
    • •
  • 3 590 tis. Kč
    • •
  • MZ
Project

Construction of recombinant mimotopes for induction of neutralizing antibodies against HIV-1 gp120 glycoprotein using high-affinity binders approach (NV15-32198A)

Development of vaccine preventing HIV-1 infection is hindered by high variability of envelope glycoprotein (Env), known target for neutralizing antibodies. Identification of several monoclonal antibodies neutralizing

EC - Imunologie

  • 2015 - 2018
    • •
  • 6 200 tis. Kč
    • •
  • 6 200 tis. Kč
    • •
  • MZ
Project

Structural studies of flaviviruses and their neutralization by antibodies (GA17-02196S)

. In addition, we will study interactions of neutralizing antibodies with ZIKV and TBEV virions. Our results will help to limit the risk of undesirable antibody-dependent antibodies.......

BO - Biofyzika

  • 2017 - 2021
    • •
  • 10 751 tis. Kč
    • •
  • 10 310 tis. Kč
    • •
  • GA ČR
Project

The study of HIV-1 Env glycosylation evolution in relation to preventative vaccine development (LH15263)

and cell-mediated immune parameters and especially titers of neutralizing antibodies SOSIP and titer of neutralizing antibodies measured against set of various HIV-1 of neutralizing antibodies us...

EC - Imunologie

  • 2015 - 2017
    • •
  • 1 986 tis. Kč
    • •
  • 1 986 tis. Kč
    • •
  • MŠMT
Project

Neutralizing nanobodies as potential therapeutics for tick-borne encephalitis (NU22-05-00659)

developed highly effective human monoclonal antibodies against the TBE virus with high, the antibodies are not effective because they cannot cross the intact blood-brain barrier. In contrast, nanobodies combine the advantages of th...

Virology

  • 2022 - 2025
    • •
  • 12 129 tis. Kč
    • •
  • 12 129 tis. Kč
    • •
  • MZ
Project

Human antibodies to tick-borne flaviviruses (GF21-05445L)

of infections every year. The human antibody response to TBEV has been studied at the level of pools of antibodies circulating in blood. In contrast, the molecular make-up and properties of individual human antibodies that...

Immunology

  • 2021 - 2023
    • •
  • 8 494 tis. Kč
    • •
  • 8 494 tis. Kč
    • •
  • GA ČR
Project

Characterization of IL-1-like properties of the coelomic fluid of Eisenia foetida earthworms (GA310/96/1259)

will be tested. The active fraction will be used in order to generate monoclonal antibodies neutralizing these effects. Neutralising IgG antibodies will be selected forimmunoaffinity will be determined. Monoclonal anti...

EB - Genetika a molekulární biologie

  • 1996 - 1998
    • •
  • 1 173 tis. Kč
    • •
  • 810 tis. Kč
    • •
  • GA ČR
Project

Passive immunization against oedema disease of pigs. (QD1196)

project will study the possibility to use antibodies neutralizing verotoxin VT2e with antibodies against VT2e will be prepared and further applied to the experimental piglets. Thedynamics of toxin neutralixing antibodi...

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 2001 - 2005
    • •
  • 2 360 tis. Kč
    • •
  • 2 360 tis. Kč
    • •
  • MZe
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