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62 (0,082s) •

Project

Molecular mechanisms of the regulation of inflammatory responses by adaptor protein PSTPIP2 (GA17-07155S)

. The disease is driven by enhanced production of IL-1β by neutrophils which are apparently binding partners regulate pro-inflammatory signaling in neutrophils and how the dysregulation of the signaling pathways in PSTPIP2-deficient...

EC - Imunologie

  • 2017 - 2021
    • •
  • 6 978 tis. Kč
    • •
  • 5 991 tis. Kč
    • •
  • GA ČR
Project

Changes of expression of pro-inflammatory enzymes caused by isoquinoline alkaloids during differentiation of promyelocytes into neutrophils (GP303/06/P193)

of enzymes whose activity is necessary for the involvement of neutrophilic granulocytes induced by dimethyl sulfoxide to differentiate into neutrophil-like cells will be used......

CE - Biochemie

  • 2006 - 2008
    • •
  • 1 044 tis. Kč
    • •
  • 1 044 tis. Kč
    • •
  • GA ČR
Project

Nuclear topology of some protooncogenes in human neutrophilic granulocytes and leukemic cells (IAB5004102)

The project will study the topology of C-MYC, ABL and BCR protoocogenes in the nuclei of human granulocytes in comparison with the topology of mentioned genes in leukemic cells that will be differentiated along the myeloid pathway taht is ch...

EB - Genetika a molekulární biologie

  • 2001 - 2003
    • •
  • 1 924 tis. Kč
    • •
  • 694 tis. Kč
    • •
  • AV ČR
Project

Molecular mechanisms of serotoninergic system interactions with cells of immune system (LD14030)

of serotonin on neutrophils under physiological as well as under pathophysiological of related G-proteins in neutrophils - determination of the expression of serotonin transporter in neutrophils and possible intracellular ...

EC - Imunologie

  • 2014 - 2016
    • •
  • 2 122 tis. Kč
    • •
  • 2 122 tis. Kč
    • •
  • MŠMT
Project

Stabilization of hypoxia-inducible factors in regulation of phenotypic and functional plasticity of neutrophil subpopulations in mouse (GJ17-26910Y)

Neutrophils are the first line of organism defense but can also contribute neutrophil subpopulations with different functional and regulatory features. Currently diversification of neutrophil populations. These data will be...

EC - Imunologie

  • 2017 - 2017
    • •
  • 1 331 tis. Kč
    • •
  • 1 331 tis. Kč
    • •
  • GA ČR
Project

Altered proportional and functional characteristics of particular neutrophil subsets as a possible trigger of relapses in patients with autoimmune neurological disorders of CNS (NU23-05-00462)

Neutrophils serve as the first line of defense against invading pathogens of neutrophilic chromatin together with antibacterial proteins originating from the neutrophil granules. The neutrophil extracellular trap (...

Immunology

  • 2023 - 2026
    • •
  • 11 685 tis. Kč
    • •
  • 11 685 tis. Kč
    • •
  • MZ
Project

Methylation of histone H3 as a prognostic marker of chronic myeloid leukemia remission (1QS500040508)

granulocytes. Monomethylated and especially dimethylated H3K9 are, however, present in granulocytes of patients with chronic myeloid leukemia (CML) without HP1 proteins. We. The exposure of methylated H3K9 in CML granulocytes

FD - Onkologie a hematologie

  • 2005 - 2009
    • •
  • 6 365 tis. Kč
    • •
  • 6 365 tis. Kč
    • •
  • AV ČR
Project

Neutrophils in juvenile idiopathic arthritis biomarkers with potential to improve clinical treatment decisions and patient care (NU20-05-00320)

. Neutrophils have an important role in pathology of these adverse effects, therefore we plan to focus on neutrophil functions in JIA patients during biological therapy. Our approach will include detailed phenotyping, functional tes...

Immunology

  • 2020 - 2023
    • •
  • 10 864 tis. Kč
    • •
  • 10 864 tis. Kč
    • •
  • MZ
Project

Identification and functional analysis of different macrophage and neutrophil subpopulations (LD15069)

. monocytes/macrophages and neutrophils) have been described quite recently. Importantly and neutrophil subpopulations, which are related to common major immune-related disorders and development of general protocols for monocyte/mac...

EC - Imunologie

  • 2015 - 2017
    • •
  • 1 628 tis. Kč
    • •
  • 1 628 tis. Kč
    • •
  • MŠMT
Project

Role of granulocytes and monocytes in induction and development of immunodeficiency disease and other immunopathological processes (NV15-28732A)

The project is focussed on monitoring the activation of granulocytes in patients with common variable immunodeficiency (CVID) and complement deficiency – hereditary angioedema (HAE). We will study the signs of granulocyte activation...

EC - Imunologie

  • 2015 - 2018
    • •
  • 11 855 tis. Kč
    • •
  • 11 098 tis. Kč
    • •
  • MZ
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