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1 586 (1,786s) •

Project

New electrochemical approaches for the study of modified fatty acids and their biomolecular interactions (GJ19-21237Y)

The proposed project deals with the analysis of modified fatty acids, especially nitro oleic, linoleic and -stearic acid. Not only nitration but also other fatty acid modifications occur under oxi...

Biophysics

  • 2019 - 2022
    • •
  • 5 843 tis. Kč
    • •
  • 5 843 tis. Kč
    • •
  • GA ČR
Project

A complex role of nitro-fatty acids in regulation of cellular functions and processes beyond the anti-inflammatory effect (GJ17-08066Y)

Nitro-fatty acids (NO2-FAs) represent a novel group of pluripotent signaling molecules, endogenously generated as an adaptive response of organism to oxidative and nitrative stress. Their effects are classically linked with...

ED - Fyziologie

  • 2017 - 2021
    • •
  • 5 721 tis. Kč
    • •
  • 5 721 tis. Kč
    • •
  • GA ČR
Project

Electrophilic nitro-fatty acids as countermeasures of ionizing radiation-induced hematopoietic damage targeting NRF2 pathway (GA23-06051S)

radiation syndrome. Administration of polyunsaturated fatty acids (FA) before and after white blood cell and platelet counts. Nitro-derivatives of FA (NO2-FA) have anti......

Cell biology

  • 2023 - 2025
    • •
  • 12 000 tis. Kč
    • •
  • 12 000 tis. Kč
    • •
  • GA ČR
Project

New Role for Nitrated Fatty Acid in Modulation of Phagocyte-derived Inflammatory Responses (GP13-40824P)

Nitro-fatty acids (NO2-FAs) represent a novel group of pluripotent signaling molecules, endogenously generated as an adaptive response of organism to oxidative stress. NO2-FAs serve as a potential chemical reserve of nitric...

EC - Imunologie

  • 2013 - 2016
    • •
  • 2 471 tis. Kč
    • •
  • 2 471 tis. Kč
    • •
  • GA ČR
Project

Prevention and therapy of chronic inflammatory diseases by nitro-fatty acids - PROTHECID (LTAUSA17160)

about the role of nitro-fatty acids (NO2-FAs) in this particular field. Beside...

ED - Fyziologie

  • 2017 - 2020
    • •
  • 4 275 tis. Kč
    • •
  • 4 275 tis. Kč
    • •
  • MŠMT
Project

Electrophilic fatty acids as the important regulators of cellular response to irradiation, genome instability, and carcinogenesis. (GA19-09212S)

Electrophilic nitro-fatty acids (NO2-FA) are crucially involved in modification of intracellular signaling pathways and display pleiotropic anti-oxidant, anti-inflammatory and anti-fibrotic activities described in different...

Cell biology

  • 2019 - 2023
    • •
  • 9 109 tis. Kč
    • •
  • 9 076 tis. Kč
    • •
  • GA ČR
Project

Fatty acid cycling by phosphate carrier and uncoupling protein 2. (ME 389)

Kinetic studies of fatty acid cycling and fatty acid interaction inhibitors. Location of the fatty acid binding site in their sequences after photoaffinity labeling with radiolabeled azido-fat...

EB - Genetika a molekulární biologie

  • 2000 - 2003
    • •
  • 1 780 tis. Kč
    • •
  • 1 100 tis. Kč
    • •
  • MŠMT
Project

Role of fatty acid binding proteins in pathophysiology of insulin resistance in humans (NR7880)

To measure the expression s of fatty acid-bunding proteins in monocytes and adipose tissue in relation to metabolism of fatty acids and selected clinical and biochemical manifestations of insulin resistance in pati...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2004 - 2006
    • •
  • 5 882 tis. Kč
    • •
  • 5 560 tis. Kč
    • •
  • MZ
Project

Genetic factors affecting fatty acid composition in beef (QH81228)

The project is focused on the possibility of influencing dietary value and especially fatty acid composition of beef by the application of molecular genetics Co-A desaturase (SCD) genotype and fatty acid compositio...

EB - Genetika a molekulární biologie

  • 2008 - 2012
    • •
  • 6 244 tis. Kč
    • •
  • 5 902 tis. Kč
    • •
  • MZe
Project

The role of free fatty acids in the pathogenesis of insulin resistance and its complications. (NB6367)

for nutritional and pharmacological interventions decreasing free fatty acids release from hypertriglyceridemic rat line, the role of long-term increased circulating level of free fatty acids on muscle resistance ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2000 - 2002
    • •
  • 3 474 tis. Kč
    • •
  • 3 474 tis. Kč
    • •
  • MZ
  • 1 - 10 out of 1 586