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2 290 (0,149s) •

Project

The role of nuclear hormone receptors in regulation of differentiation of cancer cells. (NM6253)

A study focused on identification of nuclear hormone receptors and their regulatory pathways may be important for regulation of differentiation of cancer cells.......

FD - Onkologie a hematologie

  • 2000 - 2002
    • •
  • 3 200 tis. Kč
    • •
  • 3 200 tis. Kč
    • •
  • MZ
Project

Functional genomics of nuclear hormone receptors in Caenorhabditis elegans (GA301/05/0859)

Nuclear hormone receptors (NHRs) are transcription factors that regulate, and steroids while other receptors, for which the ligands are not known yet, are called orphan receptors. In Caenorhabditis elegans, this ge...

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 4 856 tis. Kč
    • •
  • 4 856 tis. Kč
    • •
  • GA ČR
Project

Novel mechanisms of CYP3A4 enzyme regulation based on posttranslational modification of nuclear receptors - implications for pharmacotherapy (GAP303/12/0472)

CYP3A4 enzyme is the most important enzyme of drug/xenobiotic biotransformation, which metabolizes almost 50% of commonly used drugs. Nuclear receptors (NRs) such as Pregnane X receptor (PXR) and constitutive androstane

FR - Farmakologie a lékárnická chemie

  • 2012 - 2016
    • •
  • 7 548 tis. Kč
    • •
  • 7 548 tis. Kč
    • •
  • GA ČR
Project

Dominant negative mutants of nuclear hormone receptors (NC5261)

A study of the function of dominant negative nuclear hormone receptors that can be involved in pathogenesis of tumors and endocrine disorders using a molecualar biology system of Caenorhabditis elegans.......

FD - Onkologie a hematologie

  • 1999 - 2001
    • •
  • 3 011 tis. Kč
    • •
  • 3 011 tis. Kč
    • •
  • MZ
Project

ReceptorX Integrated platform for drug discovery and development (TA02010212)

Within the ReceptorX project the technological and informatics platform for nuclear receptor profiling will be established. The project is based on the collaboration of experts in research areas of nuclear receptors

EB - Genetika a molekulární biologie

  • 2012 - 2015
    • •
  • 26 037 tis. Kč
    • •
  • 15 373 tis. Kč
    • •
  • TA ČR
Project

Dynamics of nuclear receptor-mediated gene regulation implement for the understanding of detoxification functions and optimization of therapy (GA17-06841S)

Nuclear receptors such as Pregnane X receptor (PXR) and Farnesoid X receptor (FXR) have been extensively studied in various in vitro and in vivo models and their physiological functions in regulation of both metab...

FR - Farmakologie a lékárnická chemie

  • 2017 - 2019
    • •
  • 10 120 tis. Kč
    • •
  • 9 820 tis. Kč
    • •
  • GA ČR
Project

Retinoic acid nuclear receptor alfa rearrangements in retinoid induced differentiation of leukemic cells. (IZ2819)

FD - Onkologie a hematologie

  • 1995 - 1997
    • •
  • 1 346 tis. Kč
    • •
  • 1 346 tis. Kč
    • •
  • MZ
Project

Crosstalk between nuclear receptor and Wnt signaling in C. elegans (GA204/07/0948)

Nuclear receptor and Wnt signaling pathways intersect during cell differentiation, proliferation or malignant growth. The aim of this proposal is to decipher interplay between a conserved nuclear receptor NHR-25 an...

EB - Genetika a molekulární biologie

  • 2007 - 2011
    • •
  • 3 802 tis. Kč
    • •
  • 3 802 tis. Kč
    • •
  • GA ČR
Project

The role of nuclear receptors in regulation of nematode development (GA304/08/0970)

Nuclear hormone receptors (NHRs) are transcription factors that regulate metabolism and development of metazoan species in response to binding of specific ligands that include steroid hormones, retinoids, farnesoids, metabolites and...

EA - Morfologické obory a cytologie

  • 2008 - 2010
    • •
  • 5 985 tis. Kč
    • •
  • 5 985 tis. Kč
    • •
  • GA ČR
Project

Identification of nuclear hormone receptors regulating the development of C. elegans (GA304/99/0682)

Nuclear hormone receptors (NHR) form a distinct family of transcription factors that includes receptors binding steroid and thyroid hormones, retinoic acid and other small lipophilic molecules. Most members of NHR family do...

EA - Morfologické obory a cytologie

  • 1999 - 2001
    • •
  • 3 328 tis. Kč
    • •
  • 3 328 tis. Kč
    • •
  • GA ČR
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