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82 (0,096s) •

Project

Development of modular syntheses of new C-nucleosides for studying DNA polymerase specificity and for the extension of the genetic alphabet (IAA400550902)

Novel modular methodologies for synthesis of new C-nucleosides will be developed based on cross-coupling reactions of haloaryl C-nucleosides of new C-nucleosides for biological activity screening and for applications chemic...

CC - Organická chemie

  • 2009 - 2012
    • •
  • 5 860 tis. Kč
    • •
  • 5 860 tis. Kč
    • •
  • AV ČR
Project

New purine nucleoside analogues for therapeutic applications (OC D13.20)

Synthesis of purine nucleosides, heir acyclic analogues and analogues of nucleotides substituted by C=alkyl, aryl and cycloalkyl substituents as purinoceptor modulators.......

CC - Organická chemie

  • 2001 - 2003
    • •
  • 2 662 tis. Kč
    • •
  • 1 335 tis. Kč
    • •
  • MŠMT
Project

New purine nucleoside analogues for therapeutic applications (1P04OCD13.20)

Synthesis of purine nucleosides, heir acyclic analogues and analogues of nucleotides substituted by C=alkyl, aryl and cycloalkyl substituents as purinoceptor modulators.......

FR - Farmakologie a lékárnická chemie

  • 2004 - 2004
    • •
  • 891 tis. Kč
    • •
  • 400 tis. Kč
    • •
  • MŠMT
Project

Effects of antivirals and methylxanthines on placental growth; interference with nucleoside uptake and purinergic signaling in trophoblasts (GA22-17643S)

Nucleoside-derived antivirals (NDA) are used to prevent vertical transmission that NDA are substrates of placental nucleoside transporters. Methylxanthines are known extent dependent on nucleoside supply and purinergic sign...

Pharmacology and pharmacy

  • 2022 - 2024
    • •
  • 5 924 tis. Kč
    • •
  • 5 924 tis. Kč
    • •
  • GA ČR
Project

Modified nucleosides, nucleotides and oligonucleotides and their application in biomedicine (TA03010598)

Modified nucleosides, nucleotides and oligonucleotides are intensively used in medicine mainly as drugs or as components of diagnostic kits. The project is focused on the development of new tools for the detection of proliferating cells and ...

EB - Genetika a molekulární biologie

  • 2013 - 2016
    • •
  • 15 280 tis. Kč
    • •
  • 9 880 tis. Kč
    • •
  • TA ČR
Project

Combinatorial and rational approaches for the synthesis and evaluation of novel modified nucleosides with cytostatic and antimicrobial activity (GAP207/11/0344)

By combining of systematic synthesis of derivatives and analogues of active compounds, combinatorial approaches and rational design, we propose to device and prepare series of novel nucleoside derivatives and screen them for cytostatic and i...

CC - Organická chemie

  • 2011 - 2015
    • •
  • 24 168 tis. Kč
    • •
  • 24 168 tis. Kč
    • •
  • GA ČR
Project

Towards cyclohexenyl and cyclohexyl locked nucleic acids (GPP207/12/P625)

This project is focused on the synthesis of new conformationally locked nucleosides and nucleotides and their incorporation into structure of oligonucleotides. The primary objective of this study is to synthesize novel locked carbocyclic

CC - Organická chemie

  • 2012 - 2014
    • •
  • 3 643 tis. Kč
    • •
  • 3 643 tis. Kč
    • •
  • GA ČR
Project

New Antivirals and Antineoplastics (1M0508)

cytostatic effects of conformationally rigid cyclohexane nucleoside analogues, C-substituted purines with functionalized C-substituents, their nucleosides and nucleotides......

CC - Organická chemie

  • 2005 - 2011
    • •
  • 316 074 tis. Kč
    • •
  • 268 113 tis. Kč
    • •
  • MŠMT
Project

Synthesis and cytostatic activity studies of novel 2,6- and 6,8-disubstituted purine bases and nucleosides (IAB4055201)

The project will deal with regioselective cross-coupling reactions of 2,6- and 6,8-dihalopurines (9- substituted or protected bases and protected nucleosides. By this approach, a large series of title purine bases and nucleosides be...

CC - Organická chemie

  • 2002 - 2004
    • •
  • 1 333 tis. Kč
    • •
  • 665 tis. Kč
    • •
  • AV ČR
Project

Carbocyclic nucleoside analogues containing substituted norbornanes compounds with potential biological effects (GA203/05/0132)

This research project concerns syntheses of the novel carbocyclic nucleoside analogues in which the sugar portion is replaced with hydroxy- and dihydroxy(hydroxymethyl)bicyclo[2.2.1]heptanes. The resulting compounds will be routinely screene...

CC - Organická chemie

  • 2005 - 2007
    • •
  • 465 tis. Kč
    • •
  • 465 tis. Kč
    • •
  • GA ČR
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