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Projects

17 projects (0,151s) •

Project

Structural basis for co-transcriptional nucleosome reassembly mediated by Spt6 (GA22-19896S)

) and acts as a histone chaperone, which promotes the reassembly of nucleosomes following the passage of Pol II. The precise mechanism of the nucleosome reassembly mediated by Spt6 remains unclear. We propose to study the nucleo...

Biochemistry and molecular biology

  • 2022 - 2024
    • •
  • 9 832 tis. Kč
    • •
  • 9 832 tis. Kč
    • •
  • GA ČR
Project

HMGB1 protein involvement in nucleosome dynamics and transcription factors binding (GA15-01354S)

in the form of chromatin (an array of nucleosomes stabilized by histone H1). Access/disruption of the nucleosome structure by ATP-dependent remodeling complexes. Chromatin of HMGB1 on (i) nucleosome dynamics, (ii) histone ...

EB - Genetika a molekulární biologie

  • 2015 - 2017
    • •
  • 4 844 tis. Kč
    • •
  • 4 844 tis. Kč
    • •
  • GA ČR
Project

Determination of the histone H5 globular domain position within the native nucleosome using cryo-electron microscopy and single particle reconstruction. (GA304/05/2168)

is necessary for organised fibre folding. However, its position within the nucleosome still the individual nucleosome and the chromatin fibre. This project aims to determine the position of the globular domain of linker histone H5 ...

EA - Morfologické obory a cytologie

  • 2005 - 2007
    • •
  • 2 661 tis. Kč
    • •
  • 2 639 tis. Kč
    • •
  • GA ČR
Project

The structure and the expression of ribosomal RNA genes in allotetraploid and their parental plant genomes (GP204/03/P104)

The project will deal with three closely related items: The periodicity and positions of nucleosomes on tandemly repeated 5S rDNA sequences of Nicotiana sylvestris and Nicotiana tomentosiformis will be determined in nucleosomal frac...

EB - Genetika a molekulární biologie

  • 2003 - 2005
    • •
  • 750 tis. Kč
    • •
  • 750 tis. Kč
    • •
  • GA ČR
Project

Free circulating histone complexes as diagnostic tool for central nervous system (CNS) pediatric cancers. (NU23-03-00318)

of free circulating nucleosomes/histones are present elevated in various cancer nucleosomes/histones has been associated with tumor burden and malignant progression of brain tumors and free circulating nucleosomes/histones...

Genetics and heredity (medical genetics to be 3)

  • 2023 - 2026
    • •
  • 11 491 tis. Kč
    • •
  • 11 491 tis. Kč
    • •
  • MZ
Project

The interplay between the LEDGF chromatin reader and protein interaction modules (GA22-03028S)

LEDGF drives viral DNA integration and “mixed lineage” leukemia development. It can also replace the FACT complex role in overcoming the nucleosomal barrier to transcription. LEDGF recognizes a histone modification that marks actively transc...

Biochemistry and molecular biology

  • 2022 - 2024
    • •
  • 9 022 tis. Kč
    • •
  • 7 842 tis. Kč
    • •
  • GA ČR
Project

Disposition, distribution, and processing of DNA lesions in the genome of Arabidopsis thaliana plants defective in DNA repair and nucleosome assembly (GA23-06643S)

A. thaliana plants lacking histone chaperone Chromatin assembly factor 1 (fas1 and fas2 mutants) show signs of genome instability such as accumulation of DNA lesions, the loss of repetitive elements, and tandem gene duplications. We have recently sho...

Plant sciences, botany

  • 2023 - 2025
    • •
  • 9 911 tis. Kč
    • •
  • 9 911 tis. Kč
    • •
  • GA ČR
Project

Analysis of biologically important molecular complexes (VS97032)

The aim of the project is to build a laboratory focused on the study of functionally important complexes of biomacromolecules, namely those of nucleic acids and proteins, which form so called genome architecture (telomeres, centromeres, A study of th...

BO - Biofyzika

  • 1997 - 2000
    • •
  • 42 488 tis. Kč
    • •
  • 27 436 tis. Kč
    • •
  • MŠMT
Project

Disentangling transient interactions in transcription elongation (GX25-15442X)

chaperones, nucleosome remodeling, or in reading and managing epigenetic marks. Our data...

Biochemistry and molecular biology

  • 2025 - 2029
    • •
  • 43 344 tis. Kč
    • •
  • 43 344 tis. Kč
    • •
  • GA ČR
Project

Chromatin Regulation of Phaseolin Transcrption (ME10038)

Phaseolin, a major seed storage protein of Phaseolus vulgaris is encoded by phaseolin (phas) gene. During seed development, phas is expressed at exceptionally high levels but it is fully repressed in all vegetative tissues. The establishment of a rep...

EB - Genetika a molekulární biologie

  • 2010 - 2012
    • •
  • 2 280 tis. Kč
    • •
  • 2 280 tis. Kč
    • •
  • MŠMT
  • 1 - 10 out of 17