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700 (0,145s) •

Project

Hypoxia-induced Mitochondrial Adaptations as the Unifying Factor of Type 2 Diabetes Development in Sleep Apnea Syndrome (GA18-10144S)

Obstructive sleep apnea syndrome (and other human diseases) is characterized by repetitive or sustained tissue hypoxia during sleep. Mitochondria adapt to hypoxia by employing an evolutionary conserved, pr...

Endocrinology and metabolism (including diabetes, hormones)

  • 2018 - 2022
    • •
  • 10 671 tis. Kč
    • •
  • 10 671 tis. Kč
    • •
  • GA ČR
Project

Impaired Free Fatty Acids Metabolism in Obstructive Sleep Apnea Syndrome (NV15-30155A)

Obstructive sleep apnea syndrome (OSA) is a disease affecting 5-15% of population and 50-80% of type 2 diabetes mellitus (T2DM) and obese subjects. OSA causally contributes to the development of glucose intolerance...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2015 - 2018
    • •
  • 16 128 tis. Kč
    • •
  • 16 077 tis. Kč
    • •
  • MZ
Project

Modifications in Adipose Tissue Metabolism Leading to Diabetes in Sleep Apnea Syndrome (Study SAMET - Sleep Apnea and Adipose Tissue Metabolism) (GA13-27735S)

Obstructive sleep apnea (OSA), characterized by repetitive drops in hemoglobin saturation during sleep (intermittent hypoxia), is a common disorder affecting 5-15% of the general population. Although OSA is associa...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2013 - 2015
    • •
  • 6 168 tis. Kč
    • •
  • 6 168 tis. Kč
    • •
  • GA ČR
Project

Sleep Apnea Syndrome (IZ3574)

FL - Psychiatrie, sexuologie

  • 1996 - 1998
    • •
  • 1 687 tis. Kč
    • •
  • 1 595 tis. Kč
    • •
  • MZ
Project

Implications of Sleep Apnea for the Pathophysiology of Hypertrophic Cardiomyopathy (NT11401)

Specific aims are to determine: 1) If patients with hypetrophic cardiomyopathy are prone to sleep apnea 2) If obstructive sleep apnea may significantly change cardiac ablation or septal myectomy can decrea...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2011 - 2015
    • •
  • 10 199 tis. Kč
    • •
  • 10 199 tis. Kč
    • •
  • MZ
Project

Sleep apnea syndrome in acromegaly and pituitary tumors. (IZ3575)

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1996 - 1998
    • •
  • 1 697 tis. Kč
    • •
  • 1 625 tis. Kč
    • •
  • MZ
Project

Novel inhibitors of lipolysis in the treatment of lipid a glucose metabolism in obstructive sleep apnea syndrome (NU21-01-00259)

Obstructive sleep apnea syndrome (OSA) represents highly prevalent (typically overlooked, undiagnosed and untreated) disorder significantly increasing cardiovascular, cancer and overall mortality as well as increas...

Endocrinology and metabolism (including diabetes, hormones)

  • 2021 - 2024
    • •
  • 12 841 tis. Kč
    • •
  • 12 841 tis. Kč
    • •
  • MZ
Project

Remote ischemic preconditioning mediated by obstructive sleep apnea (NW25-02-00108)

ischemia just before surgery to trigger the beneficial effect. Obstructive sleep apnea (OSA) is a sleep disordered breathing syndrome characterized by episodes of upper airway collapse with concomitant hy...

Cardiac and Cardiovascular systems

  • 2025 - 2028
    • •
  • 11 328 tis. Kč
    • •
  • 11 328 tis. Kč
    • •
  • MZ
Project

Radiofrequency Induced Thermo Therapy in surgery of tissue hypertrophy (NR9474)

Radiofrequency Induced Thermo Therapy (RFITT) of tissue hypertrophy is used in treatment of obstructive sleep apnea syndrome (RFITT of the base of the tongue), hypertrophy of palatal tonsils, and palliative RFITT o...

FF - ORL, oftalmologie, stomatologie

  • 2007 - 2009
    • •
  • 4 163 tis. Kč
    • •
  • 4 019 tis. Kč
    • •
  • MZ
Project

Identification of prognostic markers associated with sleep apnea in hospitalized patients with moderate to severe COVID-19 infection (NU22-B-120)

Primary aim: To identify easily accessible markers of unfavorable prognosis related to obstructive sleep apnea that can be used to predict future clinical course of patients with COVID-19 pneumonia. Secondary aim: To evalua...

Infectious Diseases

  • 2022 - 2023
    • •
  • 2 949 tis. Kč
    • •
  • 2 949 tis. Kč
    • •
  • MZ
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