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Projects

109 projects (0,174s) •

Project

Platinated oligonucleotides for selective modulation of gene expression; relations to antisense strategy and development of new drugs. (GA305/02/1552)

by using synthetic nucleic acids (antisense oligonucleotides) complementary to RNA sequences. The advantage of the antisense oligonucleotides is their ability to recognize of theantisense oligonucleotides is to avoid the d...

FR - Farmakologie a lékárnická chemie

  • 2002 - 2004
    • •
  • 4 917 tis. Kč
    • •
  • 2 621 tis. Kč
    • •
  • GA ČR
Project

Interactions of Analogs of Oligonucleotides and Porphyrins, Potential Chemoterapeutics, with Natural Oligonucleotides (GA203/93/2352)

CF - Fyzikální chemie a teoretická chemie

  • 1993 - 1995
    • •
  • 500 tis. Kč
    • •
  • 1 000 tis. Kč
    • •
  • GA ČR
Project

The novel type of oligonucleotides composed of pyrrolidine nucleosides and enzymaticaly stable phosphonate internucleotide bond (GP203/02/D150)

Novel type of oligonucleotides based on pyrrolidine nucleosides in that project. Physical and biochemical properties of these oligonucleotides synthesis of the modified oligonucleotides. Tartaric acid would be the key start...

CC - Organická chemie

  • 2002 - 2005
    • •
  • 2 132 tis. Kč
    • •
  • 704 tis. Kč
    • •
  • GA ČR
Project

Water-soluble cationic copolymers as carriers for oligonucleotide delivery into cells (ME 362)

The self-assembly of oligonucleotides with diblock and graft copolymers of water soluble N-(2-hydroxypropyl)methacrylamide and cationic monomers with amino or quaternary ammonium groups in their side chains.......

CD - Makromolekulární chemie

  • 2000 - 2002
    • •
  • 528 tis. Kč
    • •
  • 460 tis. Kč
    • •
  • MŠMT
Project

Modified nucleosides, nucleotides and oligonucleotides and their application in biomedicine (TA03010598)

Modified nucleosides, nucleotides and oligonucleotides are intensively used in medicine mainly as drugs or as components of diagnostic kits. The project is focused on the development of new tools for the detection of proliferating cells and ...

EB - Genetika a molekulární biologie

  • 2013 - 2016
    • •
  • 15 280 tis. Kč
    • •
  • 9 880 tis. Kč
    • •
  • TA ČR
Project

Anomeric D- and L-oligonucleotides with isopolar, isosteric internucleotide linkage Synthesis, hybridization properties and spectroscopy (IAA4055902)

analogs of nucleotides and oligonucleotides based on them which contain enzyme-stable internucleotice bond, attention being paid to some specific properties of oligonucleotides oligonucleotides and 3)study of basic physico...

CC - Organická chemie

  • 1999 - 2001
    • •
  • 5 127 tis. Kč
    • •
  • 2 445 tis. Kč
    • •
  • AV ČR
Project

Isopolar phosphonate oligonucleotides as alternative to phosphorothioate ones in regulation of gene expression (GA203/05/0827)

of oligonucleotides as an alternative to phosphorothioate ones in various biological applications of isopolarphosphonate oligonucleotides in relevant experiments to find out the advantages as well. Superior resistance of proposed <...

CC - Organická chemie

  • 2005 - 2007
    • •
  • 6 142 tis. Kč
    • •
  • 6 142 tis. Kč
    • •
  • GA ČR
Project

Application of adsorptive transfer and elemination techniques in oligonucleotides and nucleic acids analysis. (IAA1163201)

and stripping voltammetry, (b) to study short oligonucleotides in dependence and electrochemical impedance spectroscopy in oligonucleotides and nucleic acids analysis electrodes bynucleic acids and oligonucleotides. Obtain...

BO - Biofyzika

  • 2002 - 2004
    • •
  • 1 481 tis. Kč
    • •
  • 1 251 tis. Kč
    • •
  • AV ČR
Project

The phosphonate oligonucleotides a tool for the study of HIV integrase inhibition. (IAA4055605)

The project is directed towards the chemical synthesis of isopolar oligonucleotide analogs containing novel-type of isosteric or nonisosteric phosphonate-based-chemical and biological properties incomparison with natural oligonucleotides...

CC - Organická chemie

  • 1996 - 1998
    • •
  • 9 691 tis. Kč
    • •
  • 2 069 tis. Kč
    • •
  • AV ČR
Project

Time resolved microfluorimetry in application to cellular monitoring of potential chemoterapetics (7AMB14FR020)

- Test of the applicability of the time-resolved microspectrofluorimetry in order to distinguish various porphyrin binding modes in complexes with oligonucleotides and aptamers. - Spectroscopic study of the complex formation between novel ca...

BO - Biofyzika

  • 2014 - 2015
    • •
  • 108 tis. Kč
    • •
  • 108 tis. Kč
    • •
  • MŠMT
  • 1 - 10 out of 109