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33 (0,107s) •

Project

The new generation of antisense agents macrocyclic conjugates with unnatural oligopeptides with ability of sequence specific binding to DNA (GA203/96/0740)

The project is aimed at the design and synthesis of structuraly diverse unnatural oligopeptides related to Distamycin (Dst) using N-heterocyclic building blocks oligopeptides and the porphyrin-type macrocycles to DNA should hence be...

CD - Makromolekulární chemie

  • 1996 - 1998
    • •
  • 1 790 tis. Kč
    • •
  • 1 554 tis. Kč
    • •
  • GA ČR
Project

Polymer conjugates of drugs targeted with specific oligopeptides (GA204/05/2255)

The project focuses on design, synthesis and study of physico-chemical and biological properties of an anti-angiogenic oligopeptide-targeted polymer drug delivery oligopeptides used as a homing device and passive targeting and accum...

CD - Makromolekulární chemie

  • 2005 - 2007
    • •
  • 5 421 tis. Kč
    • •
  • 5 421 tis. Kč
    • •
  • GA ČR
Project

Cyclic Oligopeptides Influencing a Secretion of Growth Hormone and a Process of Ageing. (GA203/94/0678)

CE - Biochemie

  • 1994 - 1996
    • •
  • 202 tis. Kč
    • •
  • 302 tis. Kč
    • •
  • GA ČR
Project

Chiroptical properties, conformation and dynamical behaviour of the middle sized oligopeptide having structural domains with different flexibility (GA203/02/0328)

Vibrational circular dichroism (VCD) spectroscopy is potentially capable to provide rather detailed information about three dimensional structure and dynamics of the difficult-to-investigate class of middle sized molecules, e.g. oligopeptides

CF - Fyzikální chemie a teoretická chemie

  • 2002 - 2004
    • •
  • 4 126 tis. Kč
    • •
  • 1 187 tis. Kč
    • •
  • GA ČR
Project

Supramolecular Structures of Amphiphilic Block Copolymers Containing Oligopeptide Segments (KJB4050311)

Hydrogel-like biodegradable copolymers featuring practical applications can be prepared combining poly(ethylene oxide) hydrophilic chains with hydrophobic oligopeptide segments (OS's containing several charged (either positively or negativel...

CD - Makromolekulární chemie

  • 2003 - 2005
    • •
  • 2 364 tis. Kč
    • •
  • 1 884 tis. Kč
    • •
  • AV ČR
Project

Adhesion, growth and differentiation of bone and vascular cells on carbon allotropes (GA204/06/0225)

adhesion receptors (e.g., RGD-containing oligopeptides or osteoblast-specific oligopeptide KRSR). Cell adhesion, growth and differentiation will also be controlled......

EI - Biotechnologie a bionika

  • 2006 - 2008
    • •
  • 3 059 tis. Kč
    • •
  • 3 059 tis. Kč
    • •
  • GA ČR
Project

Preparation of protracted-action peptide regulators of insect reproduction based on morphological changes and structure/activity relationships (GA203/98/0741)

oligopeptides containing structural elements suppressing the cleavage of peptide bonds by proteolytic enzymes. These oligopeptides will then be used as protracted-action agents......

CC - Organická chemie

  • 1998 - 2000
    • •
  • 2 248 tis. Kč
    • •
  • 984 tis. Kč
    • •
  • GA ČR
Project

Enzymaticaly degradable poly(ethylene glycol) block copolymers suitable for targeted transport of biologicaly active substances in organism (GA203/98/P096)

between the PEG blocks via oligopeptide spacers. The structure of the linkages, aminosugar, hormone). Both the linkages between the polymer blocks and the oligopeptide......

CC - Organická chemie

  • 1998 - 2000
    • •
  • 830 tis. Kč
    • •
  • 693 tis. Kč
    • •
  • GA ČR
Project

Study of hydrophobic and hydrophilic interactions in water solutions of bioanalogous polymers (IAA4050208)

The aim of the project is to clarify the role of hydrophobic and hydrophilic interactions in the konformational structure, stability and dynamics in two peptide-based polymer systems utilized as drug arriers: synthetic polypentapeptides of elastin ty...

CD - Makromolekulární chemie

  • 2002 - 2005
    • •
  • 3 430 tis. Kč
    • •
  • 1 761 tis. Kč
    • •
  • AV ČR
Project

Triterpenoid acids in supramolecular chemical biology (LD15012)

, oligopeptides etc.)., which will enable to modify physico-chemical characteristics of the target molecules with hydrophilic oligopeptides, namely those of the RGD type......

CC - Organická chemie

  • 2015 - 2017
    • •
  • 1 665 tis. Kč
    • •
  • 1 665 tis. Kč
    • •
  • MŠMT
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