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51 (0,061s) •

Project

Development of an in vitro model for the study of renal dysfunction due to pharmacotherapy (NU23-06-00045)

Renal organoids represent a modern technique enabling to study the response to pharmacotherapies in a multicellular context. The organoids make possible the unlimited and validate the technique of renal cortex organoids, id...

Urology and nephrology

  • 2023 - 2026
    • •
  • 14 342 tis. Kč
    • •
  • 14 342 tis. Kč
    • •
  • MZ
Project

Intestinal organoids as an in-vitro model for predicting the response to therapies correcting molecular defects in cystic fibrosis (NU20-07-00049)

by using a intestinal organoids that are obtained from rectal biopsies. The proposed project aims to set organoids from the Czech CF patients who carry the most common from organoids at the extremes of responses to the sti...

Paediatrics

  • 2020 - 2023
    • •
  • 11 461 tis. Kč
    • •
  • 11 461 tis. Kč
    • •
  • MZ
Project

Optimization of cystic fibrosis patient-derived cellular models to asses restoration of CFTR function in patients with cystic fibrosis (NU23-07-00079)

epithelial cells highly expressing CFTR and a derived model of intestinal organoids in air-liquid interface (ALI) and nasal organoids. The proposed project aims to set nasal epithelial cells monolayers, nasal and intestinal org...

Paediatrics

  • 2023 - 2026
    • •
  • 15 195 tis. Kč
    • •
  • 15 195 tis. Kč
    • •
  • MZ
Project

Integration of novel RNA-nanotherapeutics in patient-derived breast cancer organoids (NU23J-08-00035)

nanoparticles will be optimized with the use of patient-derived breast cancer organoids history. Furthermore, thanks to the implementation of the organoids in advanced organ markers characteristic of the tumor development of each <...

Biochemistry and molecular biology

  • 2023 - 2026
    • •
  • 6 894 tis. Kč
    • •
  • 6 894 tis. Kč
    • •
  • MZ
Project

Retinal Organoids Exploring the Effects of Photo-Stimulation on Human Retina (GA21-08182S)

Pluripotent stem cell-derived retinal organoids represent a reliable experimental retinal model, and also potential source for cell replacement therapy for treating retinal dystrophies. However, in vitro generated retinal cells are often for...

Cell biology

  • 2021 - 2023
    • •
  • 5 514 tis. Kč
    • •
  • 5 514 tis. Kč
    • •
  • GA ČR
Project

A humanized organoid-based platform for stroke modelling and mRNA-based therapeutic intervention (GA24-11364S)

technologies, disease modeling using brain organoids and mRNA-based therapeutic propose to combine these cutting-edge technologies and apply the brain organoids......

Neurosciences (including psychophysiology)

  • 2024 - 2026
    • •
  • 10 693 tis. Kč
    • •
  • 10 693 tis. Kč
    • •
  • GA ČR
Project

Constructing the Developmental Atlas of Alzheimer’s Disease using Cerebral Organoids and Single-Cell Transcriptomics (GA24-12028S)

The proposed project aims to investigate the primary cause of Alzheimer's disease (AD) by utilizing cerebral organoids derived from human induced pluripotent stem cells (iPSCs) and single-cell transcriptomics. While research on AD has cerebr...

Developmental biology

  • 2024 - 2026
    • •
  • 11 998 tis. Kč
    • •
  • 11 998 tis. Kč
    • •
  • GA ČR
Project

Analysis of tumor heterogeneity in advanced prostate cancer and novel approaches for therapy selection (NU20-03-00201)

). Cell types from organoid 3D cultures will also be analyzed by flow cytometry. Organoid culture of CRPC may be used to determine susceptibility to PARP inhibitors......

Oncology

  • 2020 - 2024
    • •
  • 13 560 tis. Kč
    • •
  • 13 488 tis. Kč
    • •
  • MZ
Project

Coupled chemo-mechanical model of normal and cancer microenvironment (GA23-04974S)

computational 3D vertex model of epithelial organoids and living organoids combined...

Applied mechanics

  • 2023 - 2025
    • •
  • 8 170 tis. Kč
    • •
  • 8 139 tis. Kč
    • •
  • GA ČR
Project

Development of brain organoid models to study the role of cellular senescence in the pathogenesis of glioblastoma (GA24-11357S)

to develop brain organoid models using decellularized brain extracellular matrix...

Oncology

  • 2024 - 2026
    • •
  • 12 422 tis. Kč
    • •
  • 11 822 tis. Kč
    • •
  • GA ČR
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