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6 (0,084s) •

Project

Prediction of risk of severe osteolysis development in total hip arthroplasty based on examination of SNPs in selected cytokine genes (NR9490)

Osteolysis(OL) is considered a major cause of hip arthroplasty failure. The exact underlying pathogenetic mechanisms are yet to be elucidated despite the relationships with wearing of PE prosthetic surfaces are generally accepted. PE wear pa...

FI - Traumatologie a ortopedie

  • 2007 - 2009
    • •
  • 4 580 tis. Kč
    • •
  • 4 326 tis. Kč
    • •
  • MZ
Project

Gene expression profiling of the periprosthetic tissues first step toward time-dependent analysis of periprosthetic osteolysis (NT11049)

1.Osteolysis(OL) is considered a major cause of hip/knee arthroplasty failure. DAMP receptors on macrophages, fibroblasts stimulated by particles induce increased inflammatory chemokine/cytokine synthesis. 2.The extent of OL depends on regul...

FI - Traumatologie a ortopedie

  • 2010 - 2014
    • •
  • 5 158 tis. Kč
    • •
  • 5 158 tis. Kč
    • •
  • MZ
Project

The influence of joint fluid composition on formation of lubricating film in THA (NT14267)

The main problem concerning total hip arthroplasty (THA) is aseptic loosening and periprosthetic osteolysis, both are related to the type and rate of joint surface wear. Wear is not a primary function of joint materials but is a result of th...

FI - Traumatologie a ortopedie

  • 2013 - 2015
    • •
  • 3 497 tis. Kč
    • •
  • 3 497 tis. Kč
    • •
  • MZ
Project

Lifetime extension of polyethylene pit in total joint replacement (IBS4050009)

The aim of the project is the assesment of major factors decreasing the usefull lifetime of polyethylene parts(UHMWPE) in human total joint replacements. Attention will be focused mainly on the process of sterilization (by gama-irradiation or by mean...

CD - Makromolekulární chemie

  • 2000 - 2002
    • •
  • 5 273 tis. Kč
    • •
  • 2 906 tis. Kč
    • •
  • AV ČR
Project

Prediction for reoperation in patients with THA and TKA based on immunogenetic signature development of risk calculator for routine clinical practice (NV16-31852A)

Periprosthetic osteolysis (PPOL) and aseptic loosening (AL), the major long-term complications of total joint arthroplasties (TJAs), as well as prosthetic joint infection (PJI) are associated with individual susceptibility to these complicat...

FI - Traumatologie a ortopedie

  • 2016 - 2019
    • •
  • 14 356 tis. Kč
    • •
  • 14 356 tis. Kč
    • •
  • MZ
Project

Biomechanical Analysis of micromotions and loosening of cemented acetabular (IAA200710504)

and induce formation of osteoagressive granuloma and consecutive osteolysis. Later...

JM - Inženýrské stavitelství

  • 2005 - 2008
    • •
  • 2 020 tis. Kč
    • •
  • 2 020 tis. Kč
    • •
  • AV ČR
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