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11 (0,163s) •

Project

Inprovement of diagnostics local and general therapy of chronic osteomyelitis (IZ3686)

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 1996 - 1998
    • •
  • 1 277 tis. Kč
    • •
  • 1 195 tis. Kč
    • •
  • MZ
Project

Novel antimicrobial peptides for topical treatment of osteomyelitis and prevention of implant-related infections in orthopedics (NV16-27726A)

method for the cure or prevention of osteomyelitis. For the experiments carried out on the model of induced osteomyelitis we will use local carriers combined with AMPs of osteomyelitis or prevention of implant related-infe...

FI - Traumatologie a ortopedie

  • 2016 - 2019
    • •
  • 7 714 tis. Kč
    • •
  • 7 714 tis. Kč
    • •
  • MZ
Project

Development and comprehensive evaluation of novel injectable, resorbable, porous bone substitute with controlled release of antimicrobial agents (NV18-05-00379)

Solution of bone defects is not always easy medical procedure, especially in the field of osteomyelitis, or near joint replacements on the surface of the attritor or exacerbate osteomyelitis. In the present project we will newly uti...

Orthopaedics

  • 2018 - 2022
    • •
  • 14 215 tis. Kč
    • •
  • 14 215 tis. Kč
    • •
  • MZ
Project

Bioactive Glass-ceramics Used in Orthopaedic Surgery. (IZ3026)

FJ - Chirurgie včetně transplantologie

  • 1995 - 1997
    • •
  • 739 tis. Kč
    • •
  • 738 tis. Kč
    • •
  • MZ
Project

Adaptor protein PSTPIP2 and chronic multifocal osteomyelitis in mouse models and human patients (GA23-06676S)

Chronic recurrent multifocal osteomyelitis (CRMO) is a chronic disease characterized by autoinflammatory lesions in the bones. The molecular basis of the disease is unknown. The most important animal model of this disease is the mouse strain...

Biochemistry and molecular biology

  • 2023 - 2025
    • •
  • 9 235 tis. Kč
    • •
  • 9 043 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanisms of the regulation of inflammatory responses by adaptor protein PSTPIP2 (GA17-07155S)

chronic multifocal osteomyelitis, caused by the absence of adaptor protein PSTPIP2...

EC - Imunologie

  • 2017 - 2021
    • •
  • 6 978 tis. Kč
    • •
  • 5 991 tis. Kč
    • •
  • GA ČR
Project

The role of interactions of adaptor protein PSTPIP2 in the development of autoinflammatory disease (GA19-05076S)

Mouse strains, in which deficiency in adaptor protein PSTPIP2 results in autoinflammatory osteomyelitis belong among the best-studied models of autoinflammatory diseases. Osteomyelitis in these mice is caused by hyperproduction of p...

Biochemistry and molecular biology

  • 2019 - 2023
    • •
  • 8 121 tis. Kč
    • •
  • 7 593 tis. Kč
    • •
  • GA ČR
Project

Function of Csk-anchoring proteins SCIMP and PSTPIP2 in leukocyte signaling and inflammation (GAP302/12/1712)

Src-family kinases (SFK) are important enzymes involved in the regulation of signaling via a number of leukocyte surface receptors.While majority of Src-family kinases (SFKs) are directly associated with cellular membranes, their main negative regula...

EC - Imunologie

  • 2012 - 2017
    • •
  • 10 212 tis. Kč
    • •
  • 10 212 tis. Kč
    • •
  • GA ČR
Project

Use of antimicrobial peptides to treatment of musculoskeletal infections with the help of local carriers used in orthopedics (NT14218)

for the treatment of osteomyelitis....

FI - Traumatologie a ortopedie

  • 2013 - 2014
    • •
  • 1 371 tis. Kč
    • •
  • 1 371 tis. Kč
    • •
  • MZ
Project

Identification of the cellular receptor for the Kingella kingae RtxA toxin and study of the potential of RtxA to disrupt the oral epithelial barrier (GA18-18079S)

Kingella kingae is a member of the commensal oropharyngeal flora of young children and until recently, the bacterium was thought to be an occasional pathogen. However, improvements in detection methods have increased the recognition of K. kingae as a...

Microbiology

  • 2018 - 2020
    • •
  • 8 869 tis. Kč
    • •
  • 8 869 tis. Kč
    • •
  • GA ČR
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