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3 006 (0,064s) •

Project

Oxidative damage of DNA in bone marrow cells of patients with myelodysplastic syndrome - subtype refractory anemia with or without ring sideroblasts. (NR8265)

Assessment of non-specific oxidative damage of DNA in cells of glycophorine A+ and A- fraction of bone marrow from patients with RA and RARS using alkaline version of comet assay combined with application of specific restriction enz...

FD - Onkologie a hematologie

  • 2005 - 2008
    • •
  • 3 477 tis. Kč
    • •
  • 3 440 tis. Kč
    • •
  • MZ
Project

Oxidative damage to retina and eys during hypoxia and hyperoxia (IZ4009)

Oxidative damage to retina and eye lens induced by hypoxia and hyperoxia in laboratory rat will be investigated at the level of lipids,structual proteins,and metabolic activity.The goal is to elucidate the mechanismus of cataract an...

FF - ORL, oftalmologie, stomatologie

  • 1997 - 1999
    • •
  • 816 tis. Kč
    • •
  • 816 tis. Kč
    • •
  • MZ
Project

Oxidatively damaged vital eukaryotic membrane proteins and their further fate yeast plasma membrane H+-ATPase (GA204/99/0488)

toxics. In the project we will (1) determine how the oxidative damage of vitally plasma membrane H+-ATPase as model of oxidatively damaged membrane protein. Yeasts damage since 2-3 % respired O2 is conver...

EB - Genetika a molekulární biologie

  • 1999 - 2001
    • •
  • 1 876 tis. Kč
    • •
  • 1 280 tis. Kč
    • •
  • GA ČR
Project

Individual DNA repair capacity induced by oxidative stress and its influence on the development and prognosis of chronic non-infectious diseases (NR7919)

The aim of the project is to assess changes in repair of DNA damaged by oxidative stress in 2 serious chronic diseases - diabetes mellitus type 1 and inflammatory bowel diseases. The acquired parameters relate to the pattern of dise...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2004 - 2006
    • •
  • 2 449 tis. Kč
    • •
  • 2 421 tis. Kč
    • •
  • MZ
Project

Role of nitric oxide in the damage of epithelial cells by reactive oxygen metabolites (GP524/02/P005)

of the nitrite oxide (NO) in epithelial cell damage caused by oxygen free radicals in consequence of oxidative stress. For this purpose appropriate models of epithelial cell lines damage by oxygen free radical don...

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 2002 - 2004
    • •
  • 382 tis. Kč
    • •
  • 246 tis. Kč
    • •
  • GA ČR
Project

Understanding and modulation of the antioxidative defence mechanisms in oxidative stress (GA524/01/1219)

Oxidative stress and oxidation-induced tissue damages are of growing clinical relevance representing a serious problem for both veterinary and human medicine It has been well documented that reactive oxygen species (ROS) an...

GJ - Choroby a škůdci zvířat, veterinární medicina

  • 2001 - 2003
    • •
  • 3 162 tis. Kč
    • •
  • 1 869 tis. Kč
    • •
  • GA ČR
Project

The influence of antioxidants on toxic and carcinogenic effect of cadmium (GA305/02/1231)

tissues. Further, the extent of oxidative DNA damage andMetals, similarly as other xenobiotics, generate oxidative stress in the organism resulting in serious diseases. It includes also DNA damage of various chara...

FR - Farmakologie a lékárnická chemie

  • 2002 - 2004
    • •
  • 2 304 tis. Kč
    • •
  • 1 884 tis. Kč
    • •
  • GA ČR
Project

The role of protective mechanisms, oxidative stress and inflammatory reaction in the progreof liver damage in patient with metabolic syndrome and possible influence of antioxidative factors (NT11247)

damage and a degree of inflammatory reaction, oxidative stress and some protectiveThe development of liver disease in metabolic syndrome (MS) could be mediated by e.g. oxidative stress or inflammatory reaction. An ability ...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2010 - 2014
    • •
  • 3 663 tis. Kč
    • •
  • 3 662 tis. Kč
    • •
  • MZ
Project

Interactions between collagen, platelets and neutrophils with respect to wound healing (GA524/07/1511)

and destructive processes necessary to remove damaged tissue. In some pathologic settings that a phagocyte- derived oxidative stress could occur and participate in the pathophysiology an extracellular collagen. On the other hand, t...

EC - Imunologie

  • 2007 - 2009
    • •
  • 3 013 tis. Kč
    • •
  • 3 013 tis. Kč
    • •
  • GA ČR
Project

Influence of drugs on metal induced oxidative stress (GA307/96/0038)

Oxidative tissue damage caused by the increased formation of free radicals represents one of the possible mechanism of toxic of many chemicals. This damage is considered to be associated with thepathogenesis of many disease...

FR - Farmakologie a lékárnická chemie

  • 1996 - 1998
    • •
  • 960 tis. Kč
    • •
  • 960 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 3 006