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1 855 (0,21s) •

Project

Research and development to increase the cell's energy potential by streamlining glycolysis and oxidative phosphorylation processes with standardized glycemic control (EG16_084/0010288)

Research and development to increase the cell's energy potential by streamlining glycolysis and oxidative phosphorylation processes with standardized glycemic control......

FP - Ostatní lékařské obory

  • 2017 - 2021
    • •
  • 15 868 tis. Kč
    • •
  • 2 287 tis. Kč
    • •
  • MPO
Project

Metabolic function and regulation of mitochondrial glycerophosphate dehydrogenase (GA303/00/1658)

of oxidative phosphorylation, induced experimentally specificity, adaptive processes) and pathological states (low activity of oxidative phosphorylation, production of oxygen radicals). The first part of the propo...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2000 - 2002
    • •
  • 3 323 tis. Kč
    • •
  • 1 775 tis. Kč
    • •
  • GA ČR
Project

The mitochondrial genome and oxidative phosphorylation system in metabolic syndrome (OC08017)

Mitochondrial oxidative phosphorylation (OXPHOS) provides most of energy in mammalian cells and tissues. OXPHOS system is uniquely encoded by both nuclear and mitochondrial genes. Dysfunction of OXPHOS are known to cause numerous ty...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2008 - 2011
    • •
  • 1 706 tis. Kč
    • •
  • 1 706 tis. Kč
    • •
  • MŠMT
Project

Metabolic pathways of oxidative stress resistance in endothelial cells (GA22-34507S)

. Previously, we and collaborators demonstrated that oxidative phosphorylation (OXPHOS) (via autophagy) and fatty acid oxidation (FAO) both provide oxidative stressOxidative stress in endothelial cells (EC...

Biochemistry and molecular biology

  • 2022 - 2024
    • •
  • 9 651 tis. Kč
    • •
  • 9 651 tis. Kč
    • •
  • GA ČR
Project

Oxidative metabolism in lymphocytes of obese humans (OC 918.40)

inlipolytic and glycolytic metabolism. Lately, mitochondrial oxidative capacities, oxidative phosphorylation system and production of ATP seem to be influenced, too. We will test the hypothesis, that oxidative met...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 2000 - 2003
    • •
  • 2 901 tis. Kč
    • •
  • 1 010 tis. Kč
    • •
  • MŠMT
Project

Rearrangement of cellular metabolism triggered by impairment of oxidative phosphorylation (GA21-18993S)

Mitochondria play an important role in ATP production and cellular homeostasis by provision of intermediates for biosynthetic pathways. In humans, the defects of oxidative phosphorylation (OXPHOS) lead to severe mitochondrial diseas...

Endocrinology and metabolism (including diabetes, hormones)

  • 2021 - 2024
    • •
  • 7 137 tis. Kč
    • •
  • 7 137 tis. Kč
    • •
  • GA ČR
Project

Antioxidant role vs. mitochondrial morphology and their impairment during oxidative stress in diabetic tissues and ischemic heart (IAA500110701)

Oxidative stress or nonphysiological redox signaling of mitochondrial origin morphology" of phosphorylating and "bulky morphology" of non-phosphorylating in situ oxidative link to extracelular matrix, changes under...

ED - Fyziologie

  • 2007 - 2011
    • •
  • 6 265 tis. Kč
    • •
  • 6 265 tis. Kč
    • •
  • AV ČR
Project

Addiction to oxidative phosphorylation in cancer and its relation to tumour initiation and therapy (GA16-12816S)

Recent research indicates that cancer cells require functional mitochondria to initiate and form tumours in the mouse in vivo models. Cancer cells with dysfunctional mitochondria are able to „steal“ mitochondria by horizontal transfer from the host...

FD - Onkologie a hematologie

  • 2016 - 2018
    • •
  • 8 417 tis. Kč
    • •
  • 8 363 tis. Kč
    • •
  • GA ČR
Project

New biological methods in prenatal diagnosis of mitochondrial diseases. (IZ4035)

Electrophoretical,functional and molecular biological analysis of mitochondrial oxidative phosphorylation proteins in early stages of intrauterine development with perspective of prenatal diagnostics in families with mitochondrial e...

FB - Endokrinologie, diabetologie, metabolismus, výživa

  • 1997 - 1999
    • •
  • 3 810 tis. Kč
    • •
  • 3 510 tis. Kč
    • •
  • MZ
Project

Supramolecular assemblies in structural organization of inner mitochondrial membrane (GPP303/10/P227)

Recently, our understanding of oxidative phosphorylation (OXPHOS) complexes organization in the inner mitochondrial membrane changed substantially. They are now viewed as semi-rigid multimer associates termed supercomplexes. Althoug...

ED - Fyziologie

  • 2010 - 2014
    • •
  • 2 015 tis. Kč
    • •
  • 2 015 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 1 855