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30 (0,088s) •

Project

Modified oxime nucleophiles for reactivation of phosphylated cholinesterases (LUAKR25007)

of acetylcholinesterase so called oximes are causal treatment of such intoxications. Oximes are able, the current research is based on searching for oximes with increased reactivation effect of modified oxime nucl...

Medicinal chemistry

  • 2025 - 2028
    • •
  • 5 000 tis. Kč
    • •
  • 5 000 tis. Kč
    • •
  • MŠMT
Project

Research of oxime-CB(7) complexes for central nervous system penetration of quaternary acetylcholinesterase reactivator (GA18-08937S)

Acetylcholinesterase (AChE; E.C. 3.1.1.7) reactivators (also known as oximes the biological barriers. Oximes are highly hydrophilic compounds due to their quaternary nitrogens and hydrophilic oxime groups included in struct...

Neurosciences (including psychophysiology)

  • 2018 - 2022
    • •
  • 6 658 tis. Kč
    • •
  • 6 511 tis. Kč
    • •
  • GA ČR
Project

Chemical and electrochemical properties of oximes - antidotes against nervous gases (1P05ME785)

systematical and self-contained characterisation of acidoalkaline and oxidative and reductive properties and chemical reactions of different type of oximes......

CF - Fyzikální chemie a teoretická chemie

  • 2005 - 2008
    • •
  • 611 tis. Kč
    • •
  • 611 tis. Kč
    • •
  • MŠMT
Project

Modified nucleophiles for reactivation of cholinesterases inhibited by organophosphorus compounds (GA21-03000S)

so called oximes are causal treatment of such intoxication. In organism, oxime is forming oximate anion which is able to detoxify organophosphate and restore acetylcholinesterase function. Oximes can be used in co...

Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

  • 2021 - 2023
    • •
  • 10 774 tis. Kč
    • •
  • 10 774 tis. Kč
    • •
  • GA ČR
Project

Encapsulation of bisquaternary oxime reactivators into solid lipid nanoparticles for enhanced reactivation of cholinesterases in CNS (GA25-15339S)

Quaternary oxime reactivators of cholinesterases are used for life endangering intoxications by organophosphates. They are effective in the peripheral tissues of encapsulation of bisquaternary oxime reactivators into solid lipid nan...

Neurosciences (including psychophysiology)

  • 2025 - 2027
    • •
  • 13 027 tis. Kč
    • •
  • 13 027 tis. Kč
    • •
  • GA ČR
Project

Biodistribution and real-time monitoring of free or apoferritin-encapsulated charged cholinesterase reactivators (GA22-14568S)

Oxime cholinesterase reactivators are used for life endangering intoxications to encapsulate the oxime reactivators, help their blood-brain barrier permeation and release. This project focuses on traced oxime reactivators a...

Toxicology

  • 2022 - 2024
    • •
  • 11 763 tis. Kč
    • •
  • 11 208 tis. Kč
    • •
  • GA ČR
Project

Centrally acting antidotes for the treatment of organophosphorus poisoning (NV17-32801A)

countermeasures against OP poisoning involves muscarinic inhibition and the use of oxime a reactivator. The latter, however, is limited by a versatility ox oximes and by the low penetration of reactivators into the brain. The aim o...

FR - Farmakologie a lékárnická chemie

  • 2017 - 2020
    • •
  • 8 990 tis. Kč
    • •
  • 8 990 tis. Kč
    • •
  • MZ
Project

The study of genotoxicity of sarin, soman and HI-6 oxime, and their influence on the effect of mutagenic and carcinogenic compounds (MO66021299108)

The risk assessment of the carcinogenicity of low doses of nerve paralytic agents and HI-6....

EB - Genetika a molekulární biologie

  • 1999 - 2001
    • •
  • 487 tis. Kč
    • •
  • 487 tis. Kč
    • •
  • MO
Project

New possibilities of therapy of cyclosin intoxication Synthesis and testing of new acethylcholinesterase reactivators (ONVLAJEP20031)

The aim of this project is synthetizing, in vitro and in vivo testing of new acetylcholinesterase reactivators that will be effective enough for treatment of cyclosin intoxication. Potentially effective compounds will be chosen from original structur...

FP - Ostatní lékařské obory

  • 2003 - 2005
    • •
  • 1 429 tis. Kč
    • •
  • 864 tis. Kč
    • •
  • MO
Project

Non-specific and versatile cholinesterase reactivators to countermeasure organophosphorus intoxication (GA22-05318S)

and experimental reactivators are composed of two parts, one with oxime group responsible by addition of another oxime group into molecule. We will prepare series of hybrids......

Analytical chemistry

  • 2022 - 2024
    • •
  • 10 378 tis. Kč
    • •
  • 10 378 tis. Kč
    • •
  • GA ČR
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