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6 (0,064s) •

Project

Functional role of oxysterols in plant photosynnthesis (GAP501/11/1650)

of plant extracts with carriers prepared by oriented immobilisation of oxysterol to bindthese compounds. We already proved the regulatory effect of oxysterols on some of these proteins (RuBisCO, OEC, glutathione-S-transferase), and...

CE - Biochemie

  • 2011 - 2014
    • •
  • 5 850 tis. Kč
    • •
  • 5 850 tis. Kč
    • •
  • GA ČR
Project

Role of oxysterols, antiestrogens and phytoestrogens in drug resistance of cancer cells in patients and experimental models (GC13-25222J)

Czech part of collaborative Czech-Taiwan project aims to study expression and genetic variability of oxysterol-signaling genes, estrogen receptors (ER cancer patients. Oxysterols as antagonists of ER/AEBS will be determined in serum...

FD - Onkologie a hematologie

  • 2013 - 2017
    • •
  • 3 177 tis. Kč
    • •
  • 3 177 tis. Kč
    • •
  • GA ČR
Project

Importance of oxysterol signaling for endocrine therapy of breast carcinoma (NV17-28470A)

In the frame of this project, we plan to evaluate importance of genetic and phenotypic markers of oxysterol signaling for endocrine therapy of breast carcinoma. In the long-term perspective, we expect significant socio-economic benefit for b...

CE - Biochemie

  • 2017 - 2020
    • •
  • 6 932 tis. Kč
    • •
  • 6 683 tis. Kč
    • •
  • MZ
Project

The use of affinity chromatography for identification of sterol-binding proteins from plants (IAA4055204)

Recent identification of brassinosteroids as essential hormones, raised questions about the mode of steroid-binding and transport in higher plants. The genome of Arabidopsis contains at least 4 different loci encoding potential orthologs of oxyst...

CC - Organická chemie

  • 2002 - 2006
    • •
  • 4 941 tis. Kč
    • •
  • 2 661 tis. Kč
    • •
  • AV ČR
Project

Structural and functional analysis of regulation of the lipid-transport protein ORP8 (GF21-27735K)

Lipids transport between various membranous intracellular organelles is mediated either by the well described vesicular transport or by a conserved protein family specialized in transporting lipids. Oxysterol-binding protein (OSBP)-related p...

Biochemistry and molecular biology

  • 2021 - 2023
    • •
  • 4 220 tis. Kč
    • •
  • 3 260 tis. Kč
    • •
  • GA ČR
Project

Bottom-up unraveling of biophysical determinants of ORP5/8 mediated lipid transport using in vitro reconstitution and model membranes (GA19-18917S)

Membrane homeostasis requires organized transport of lipids from the endoplasmic reticulum (ER) to target membrane. Oxysterol binding protein related proteins (ORPs) represent a family of lipid transfer proteins, two members of which, ORP5/8...

Biochemistry and molecular biology

  • 2019 - 2021
    • •
  • 3 705 tis. Kč
    • •
  • 3 705 tis. Kč
    • •
  • GA ČR
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