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Projects

154 projects (0,307s) •

Project

Wild type and mutant p53 tumor suppressor protein. Intermolecular interactions, changes in conformation and new micro-methods of their analysis (IAA500040513)

The tumor suppressor protein p53 plays a critical role in the control of cell suppressor function of the p53 protein and gain-of-function enhancing the tumorogenicity of mutated p53, including DNA binding. Almost nothing is...

CE - Biochemie

  • 2005 - 2008
    • •
  • 2 930 tis. Kč
    • •
  • 2 930 tis. Kč
    • •
  • AV ČR
Project

Mutants of tumor supressor protein p53 and regulation of thei DNA binding activity (KJB500040502)

The p53 tumor suppressor protein plays a critical role in the cellular response repair, cell proliferation and apoptosis. Mutants of p53 protein are found in more than 50% ofcancer cases. Detailed study of p53 mutants, whic...

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 1 230 tis. Kč
    • •
  • 1 230 tis. Kč
    • •
  • AV ČR
Project

Binding of tumor suppressor protein p53 to DNA. Effect of DNA supercoling and protein postsynthetic modification (IAA4004110)

protein p53 and its binding to DNA. Better understanding of this key protein are directed at: (i) the effect of postsynthetic modifications of the p53 protein on its superhelix density on p53 binding, (iii) the effect of s...

CE - Biochemie

  • 2001 - 2004
    • •
  • 4 874 tis. Kč
    • •
  • 1 990 tis. Kč
    • •
  • AV ČR
Project

Influence of DNA superhelicity on sequence specific and structure selective binding of the p53 protein (GP301/04/P025)

Tumor suppressor protein p53 is one of the most important regulators of cell proliferation, differentiation and programmed cell death. P53 is mutated in more than 50% of cancer cases. This project is focused towards studies of p...

CE - Biochemie

  • 2004 - 2006
    • •
  • 720 tis. Kč
    • •
  • 720 tis. Kč
    • •
  • GA ČR
Project

Interactions between mutated p53 proteins and p73 isoforms and their impact on p73 DNA binding and transactivation (GP301/04/P023)

The p53 family includes p53, p63 and p73 proteins that have a high degree of structural identity. The interaction between the tumour suppressor protein p53 that mutated p53proteins gain the ability to interact with p73. For...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 377 tis. Kč
    • •
  • 377 tis. Kč
    • •
  • GA ČR
Project

Study of posttranslation modification of the tumor suppressor protein p53, its homologues and interacting proteins in human cancer cell lines (GP301/07/P160)

Detailed knowledge of modification and DNA binding activity of p53 protein is fundamental for understanding of p53-dependent pathways. In our study we intend to analyze in detail posttranslational modifications of the p53 p...

EB - Genetika a molekulární biologie

  • 2007 - 2009
    • •
  • 1 365 tis. Kč
    • •
  • 1 365 tis. Kč
    • •
  • GA ČR
Project

Tumor suppressor proteins of p53 family and chromosomal protein HMG1. A search for a functional link. (GA301/02/0952)

p53 is one of the most extensively studied genes. p53 is a crucial tumor (apoptosis). The two novel p53 family members, p73 and p63, display a striking similarity to functional domains of p53 but diverge from p...

EB - Genetika a molekulární biologie

  • 2002 - 2004
    • •
  • 3 664 tis. Kč
    • •
  • 1 947 tis. Kč
    • •
  • GA ČR
Project

Development of novel therapeutic strategies through sensitising tumour cells to anti-cancer drugs by targeting p53-kinases and p53 homologues (GA301/05/0416)

transcriptional activation is the protein p53. Our proposal combines the proteomic and genomic approaches in analysis of functional status of p53 and its homologues. We will accompany project will evaluate effects of inhibiting

FD - Onkologie a hematologie

  • 2005 - 2007
    • •
  • 2 970 tis. Kč
    • •
  • 2 970 tis. Kč
    • •
  • GA ČR
Project

Comparative study of DNA interacting properties of the tumor suppressor p53 protein isoforms (GA18-15548S)

it was demonstrated that the human TP53 gene encodes at least 12 p53 isoforms with different of various p53-isoforms changes cell fate decisions. P53 protein works mainly as a transcription factor, however detailed biochem...

Oncology

  • 2018 - 2020
    • •
  • 6 593 tis. Kč
    • •
  • 6 398 tis. Kč
    • •
  • GA ČR
Project

Interactions of wild type and mutant p53 proteins with damaged DNA and their roles in cellular response to anticancer chemotherapy (IAA500040701)

Interactions of tumor suppressor protein p53 with DNA are crucial for its biological activities. It was suggested that not only the wild type (wt) p53 sequence-specific DNA binding, but also ability of both wt and mutant (mut) p...

EB - Genetika a molekulární biologie

  • 2007 - 2010
    • •
  • 4 824 tis. Kč
    • •
  • 4 824 tis. Kč
    • •
  • AV ČR
  • 1 - 10 out of 154