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11 004 (0,152s) •

Project

Mutants of tumor supressor protein p53 and regulation of thei DNA binding activity (KJB500040502)

and/or acrylamide gel. We will examine the possibility of activation p53 mutants to DNA binding using specific phosphorylation, monoclonal antibodies and binding with other p53 p53 mutan...

EB - Genetika a molekulární biologie

  • 2005 - 2007
    • •
  • 1 230 tis. Kč
    • •
  • 1 230 tis. Kč
    • •
  • AV ČR
Project

Interactions of wild type and mutant p53 proteins with damaged DNA and their roles in cellular response to anticancer chemotherapy (IAA500040701)

-specific DNA binding, but also ability of both wt and mutant (mut) p53 to recognize DNA binding, and (3) influence of genotoxic substances on mut p53 binding to genomic DNA of g...

EB - Genetika a molekulární biologie

  • 2007 - 2010
    • •
  • 4 824 tis. Kč
    • •
  • 4 824 tis. Kč
    • •
  • AV ČR
Project

Study of posttranslation modification of the tumor suppressor protein p53, its homologues and interacting proteins in human cancer cell lines (GP301/07/P160)

Detailed knowledge of modification and DNA binding activity of p53 protein modification on its DNA binding and changes of the p53 activity induced by genotoxic to the key mechani...

EB - Genetika a molekulární biologie

  • 2007 - 2009
    • •
  • 1 365 tis. Kč
    • •
  • 1 365 tis. Kč
    • •
  • GA ČR
Project

Binding of tumor suppressor protein p53 to DNA. Effect of DNA supercoling and protein postsynthetic modification (IAA4004110)

protein p53 and its binding to DNA. Better understanding of this key protein of the complex p53 protein molecules and on p53 binding to DNA. binding to DNA and particul...

CE - Biochemie

  • 2001 - 2004
    • •
  • 4 874 tis. Kč
    • •
  • 1 990 tis. Kč
    • •
  • AV ČR
Project

Influence of DNA superhelicity on sequence specific and structure selective binding of the p53 protein (GP301/04/P025)

play crucial role in p53 protein function. DNA protein binding is often p53 binding to sets of topoisomeric samples and compare with p53 binding to DNA to study binding...

CE - Biochemie

  • 2004 - 2006
    • •
  • 720 tis. Kč
    • •
  • 720 tis. Kč
    • •
  • GA ČR
Project

DNA binding, stress-induced expression and transactivation activity of p73 protein isoforms (GAP301/11/2076)

) by selected p73 and p53 isoforms and (ii) on studies of DNA-binding and transactivation activities of both exogenous and endogenous p73 and p53 isoforms in different cell lines about their DNA-<...

EB - Genetika a molekulární biologie

  • 2011 - 2015
    • •
  • 5 953 tis. Kč
    • •
  • 5 953 tis. Kč
    • •
  • GA ČR
Project

The study of mechanisms regulating the activity of p53 protein and the possibilities of its latent forms activation in cancer cell (GA301/00/P094)

binding to both linear and supercoiled DNA. The ability of the p53 protein to function to cellularstress. Human p53 protein is a nuclear phosphoprotein. Its biochemical activity involves the ability to

EB - Genetika a molekulární biologie

  • 2000 - 2002
    • •
  • 730 tis. Kč
    • •
  • 627 tis. Kč
    • •
  • GA ČR
Project

Comparative study of DNA interacting properties of the tumor suppressor p53 protein isoforms (GA18-15548S)

and their DNA binding properties is missing. In this project, we will study the DNA binding properties of p53 isoforms in the context of epigenetic modifications and local DNA structures. We will...

Oncology

  • 2018 - 2020
    • •
  • 6 593 tis. Kč
    • •
  • 6 398 tis. Kč
    • •
  • GA ČR
Project

Local DNA structures and their role in mutant p53 protein function in human tumours (GA22-21903S)

cancers. Wild-type p53 binds DNA sequence-specifically, but also recognizes various. Differences in mutant p53 binding to structured DNAs are poorly understood. We will systematically study b...

Oncology

  • 2022 - 2024
    • •
  • 7 056 tis. Kč
    • •
  • 7 056 tis. Kč
    • •
  • GA ČR
Project

Interactions of tumor suppressor proteins with DNA. Roles of DNA conformation and protein modifications (GA204/02/0734)

The ability of tumor suppressor protein p53 to bind to specific DNA sequences and recombination. Loss of the p53 DNA binding functions frequently results in cancer mutants (involving the p53

CE - Biochemie

  • 2002 - 2004
    • •
  • 4 448 tis. Kč
    • •
  • 3 042 tis. Kč
    • •
  • GA ČR
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