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12 (0,048s) •

Project

Unravelling the regulation and interactions of p63. (GA19-06530S)

p63 is a member of the p53 family but has distinct functions in normal development and cancer. Like p53, many of the transcriptional targets of p63 are known, but, unlike p53, how p63 is regulated at transcriptional/post-tr...

Cell biology

  • 2019 - 2023
    • •
  • 8 388 tis. Kč
    • •
  • 7 809 tis. Kč
    • •
  • GA ČR
Project

The role of homologues, p73, p63 and KET proteins, in cell cycle, malignant transformation of the cell and apoptosis. (NC6404)

One of our major interests is to study the functions of p73alpha,p73beta,KET and p63 homologues of p53 tumour suppressor in developmental and cell cycle regulation, in tumour biology as well as functional interactions among these proteins. W...

FD - Onkologie a hematologie

  • 2000 - 2002
    • •
  • 5 858 tis. Kč
    • •
  • 5 846 tis. Kč
    • •
  • MZ
Project

p63 and p73 proteins as predictive markers in clinical oncology. (NT14602)

Primary experiments will be performed using MDA-MB-468 cell line derived from triple-negative breast carcinoma. Inducible expression of p63 protein in this cell line allows characterizing the role of p63 and its isoforms in cancer c...

FD - Onkologie a hematologie

  • 2013 - 2015
    • •
  • 4 961 tis. Kč
    • •
  • 4 961 tis. Kč
    • •
  • MZ
Project

The role of p63 expression in human epithelial cells (GPP301/10/P431)

the role of p63 in breast cancer cells using over-expression strategies to uncover the ability of p63 to directly influence differentiation pathways and phenotypic markers......

EB - Genetika a molekulární biologie

  • 2010 - 2012
    • •
  • 1 550 tis. Kč
    • •
  • 1 550 tis. Kč
    • •
  • GA ČR
Project

Guanine quadruplex-mediated functions of p53, p63 and p73 proteins in cancer biology (GA19-15168S)

-specific nucleic acid interactions of p63/p73 isoforms in comparison to p53 and SP1. G cells. The properties of p63/p73 isoforms, DNA topology and protein-protein......

Biochemistry and molecular biology

  • 2019 - 2022
    • •
  • 3 782 tis. Kč
    • •
  • 3 776 tis. Kč
    • •
  • GA ČR
Project

Influence of conformation motifs and epigenetic modifications to DNA binding properties of p53 family proteins (GA15-21855S)

An altered pattern of epigenetic modifications is central to many common human diseases, including cancer. DNA methylation, histone deacetylation, and methylation of histones are often associated with a repressed chromatin state and with the silencin...

EB - Genetika a molekulární biologie

  • 2015 - 2017
    • •
  • 6 795 tis. Kč
    • •
  • 6 795 tis. Kč
    • •
  • GA ČR
Project

Interactions of p53 family proteins with biologically significant DNA quadruplexes (GA13-36108S)

Tumor suppressor function of p53, p63 and p73 proteins is strongly dependent on DNA binding activities. Remarkable functional flexibility of p53 (from transcription regulation to genome stability maintenance) is connected with different mode...

EB - Genetika a molekulární biologie

  • 2013 - 2015
    • •
  • 4 919 tis. Kč
    • •
  • 4 919 tis. Kč
    • •
  • GA ČR
Project

Tumor suppressor proteins of p53 family and chromosomal protein HMG1. A search for a functional link. (GA301/02/0952)

p53 is one of the most extensively studied genes. p53 is a crucial tumor suppressor for preventing the malignant transformation of cells by regulating a number of (down-stream) genes related to the cell-cycle control and programmed cell death (apopto...

EB - Genetika a molekulární biologie

  • 2002 - 2004
    • •
  • 3 664 tis. Kč
    • •
  • 1 947 tis. Kč
    • •
  • GA ČR
Project

Interactions between mutated p53 proteins and p73 isoforms and their impact on p73 DNA binding and transactivation (GP301/04/P023)

The p53 family includes p53, p63 and p73 proteins that have a high degree of structural identity. The interaction between the tumour suppressor protein p53 and the p73 protein is very weak under physiological conditions but it was shown that...

EB - Genetika a molekulární biologie

  • 2004 - 2006
    • •
  • 377 tis. Kč
    • •
  • 377 tis. Kč
    • •
  • GA ČR
Project

Interactions of p73 protein and its isoforms with DNA. Influences of DNA supercoiling, conformation and anticancer drugs (GP204/07/P476)

The p73 protein shares a remarkable homology with closely related protein p53. It exists in many isoforms that differ in their structure and functions. It was found that p73 is not a classic tumour suppressor, but it is crucial for proper function of...

EB - Genetika a molekulární biologie

  • 2007 - 2009
    • •
  • 1 056 tis. Kč
    • •
  • 1 056 tis. Kč
    • •
  • GA ČR
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