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459 (0,129s) •

Project

Combined Immunotherapy of Tumours Induced by Human Papillomavirus (NR8004)

The aim of the project is to develop an immunotherapeutic procedure against papilloma virus-associated tumours employing prime/boost strategy. The approach combines heterologous vaccines. They include DNA vaccines, recombinant vacci...

FD - Onkologie a hematologie

  • 2004 - 2006
    • •
  • 13 021 tis. Kč
    • •
  • 10 895 tis. Kč
    • •
  • MZ
Project

Vectors for gene therapy targeted on stromal cells of solid tumors (NR9238)

Investigation of an anti-tumor therapeutic DNA vaccine and vectors for gene therapy targeting tumor fibroblasts in mouse model of tumors induced by papilloma virus HPV16. DNA vaccine will provide immunization against fibroblast acti...

FD - Onkologie a hematologie

  • 2007 - 2009
    • •
  • 9 764 tis. Kč
    • •
  • 9 542 tis. Kč
    • •
  • MZ
Project

Use of dendritic cells infected by attenuated recombinant vaccinia viruses for eliciting of specific immune response (GA310/99/0543)

papilloma virus 16 on the growth of tumors induced by this virus.Use of dendritic cells infected by attenuated recombinant vaccinia viruses the vaccine based on infection of dendritic cells (DC) by recombinant vac...

FN - Epidemiologie, infekční nemoci a klinická imunologie

  • 1999 - 2001
    • •
  • 2 745 tis. Kč
    • •
  • 2 625 tis. Kč
    • •
  • GA ČR
Project

Expression of papillomavirus antigenic epitopes in plants using plant viral vector (GA521/06/0973)

The aim of the proposed project is to prepare protein antigens derived from human papilloma virus HPV16 and to optimize their expression in plants for the purpose of developing experimental anti-HPV16 vaccines. We propose the produc...

EE - Mikrobiologie, virologie

  • 2006 - 2008
    • •
  • 3 909 tis. Kč
    • •
  • 3 909 tis. Kč
    • •
  • GA ČR
Project

Biosafe plant virus expression system for transient production of human papillomavirus oncoproteins and their use for therapeutic vaccine development (GA521/09/1525)

a stringent containtment of the recombinant viruses and provides us with biosafe transient...

EI - Biotechnologie a bionika

  • 2009 - 2011
    • •
  • 4 792 tis. Kč
    • •
  • 4 792 tis. Kč
    • •
  • GA ČR
Project

Structual antigens of papovaviruses fuctions , cellular interactions and utilisation for gene therapy purposes (GA204/96/0256)

polyoma- and papilloma- virus late antigens and their interactions with host cell...

EB - Genetika a molekulární biologie

  • 1996 - 1998
    • •
  • 3 048 tis. Kč
    • •
  • 2 567 tis. Kč
    • •
  • GA ČR
Project

Polyomavirus Pseudocapsids as Vectors Applications for Genetic and Immunological Therapeutic Purposes of Modified VP1 Pseudocapsids (OK 372)

be extrapolated to other, human papovaviruses (papilloma virus, JCV or BKV). For the optimal...

EE - Mikrobiologie, virologie

  • 1998 - 2001
    • •
  • 2 773 tis. Kč
    • •
  • 1 853 tis. Kč
    • •
  • MŠMT
Project

Mechanisms of protective immunity against tumours with different expression of immunodulatory molecules (IAA500520807)

To design effective protocols for vaccination and immunotherapy of tumour variants of the same aetiology whose phenotype has been modified by immunoediting, a better understanding of the differences in the mechanisms of specific protective immunity a...

FD - Onkologie a hematologie

  • 2008 - 2010
    • •
  • 2 800 tis. Kč
    • •
  • 2 800 tis. Kč
    • •
  • AV ČR
Project

Plant production of human papillomavirus proteins and immunogenic properties of transgenic plant tissues (GA521/05/2092)

The aim of the project is the regeneration of transformed plants of tomato, potato, carrot and lettuce that produce large amounts of human papillomavirus 16 proteins LI and E7. The major etiological role of particular types of human papillomaviruses ...

EI - Biotechnologie a bionika

  • 2005 - 2007
    • •
  • 4 356 tis. Kč
    • •
  • 4 356 tis. Kč
    • •
  • GA ČR
Project

Development of a Novel Recombinogenic Technique for Chloroplast Transformation and its Use for Production of human papillomavirus E7 Protein in Plants (IAA500960903)

Our aim is to develop more efficient method for plant chloroplast transformation using biolistic bombardment with linear DNA vectors together with chloroplast cassettes expressing bacteriophage lambda Red proteins. The idea stems from experiments wit...

EI - Biotechnologie a bionika

  • 2009 - 2012
    • •
  • 4 613 tis. Kč
    • •
  • 4 613 tis. Kč
    • •
  • AV ČR
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