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149 (0,06s) •

Project

Purinergic P2X receptors and their role in suprachiasmatic nuclei of hypothalamus (IAA500110702)

cells in culture and acutelly isolated or organotypic SCN slices. Patch clamp...

ED - Fyziologie

  • 2007 - 2009
    • •
  • 1 863 tis. Kč
    • •
  • 1 863 tis. Kč
    • •
  • AV ČR
Project

Cell volume regulation in glial cells during brain ischemia/reperfusion (GAP303/10/1338)

or hypotonic stress will be measured by the patch-clamp technique, and the mRNA levels...

FH - Neurologie, neurochirurgie, neurovědy

  • 2010 - 2012
    • •
  • 3 996 tis. Kč
    • •
  • 3 996 tis. Kč
    • •
  • GA ČR
Project

Effect of ethanol and its principle metabolite acetaldehyde on cardiac inward rectifier potassium currents a link to atrial fibrillation related to alcohol consumption? (NT14301)

of the effect of ethanol and acetaldehyde on IK1 and IK(Ach) by whole cell patch clamp...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2013 - 2015
    • •
  • 3 369 tis. Kč
    • •
  • 3 229 tis. Kč
    • •
  • MZ
Project

Modulatory role of sigma signalling in electromechanical coupling of isolated cardiomyocyte and heart (GA305/04/1385)

of sigma ligands in heart muscle voltage clamp and patch clamp techniques will be used...

ED - Fyziologie

  • 2004 - 2006
    • •
  • 1 509 tis. Kč
    • •
  • 1 509 tis. Kč
    • •
  • GA ČR
Project

Clinical significance and electrophysiological evaluation of KCNQ1 gene mutation c.926C>T (p.T309I) as a possible long QT syndrome founder mutation (NV16-30571A)

Mutations in genes encoding cardiac ionic channels and related proteins are identified in ~50% families with the long QT syndrome. Each family is usually characterized by its own mutation; the same mutation found in unrelated families living in the s...

FA - Kardiovaskulární nemoci včetně kardiochirurgie

  • 2016 - 2020
    • •
  • 10 413 tis. Kč
    • •
  • 10 381 tis. Kč
    • •
  • MZ
Project

Functional assessment of genetic variants in clinically “true” cases of idiopathic ventricular fibrillation in vitro and in silico modelling to reveal the arrhythmogenic mechanism (NU22-02-00348)

using measurements of ionic currents by the whole cell patch clamp technique...

Cardiac and Cardiovascular systems

  • 2022 - 2025
    • •
  • 14 750 tis. Kč
    • •
  • 14 750 tis. Kč
    • •
  • MZ
Project

The role of glutamate receptors during postnatal development of motoneurones (GA305/96/0680)

of patch clamp recording from spinal cord slices will be used. The goal of this study...

ED - Fyziologie

  • 1996 - 1998
    • •
  • 1 107 tis. Kč
    • •
  • 695 tis. Kč
    • •
  • GA ČR
Project

The structure and function of the nicotinic acetylcholine receptor (IAA7011902)

We will use a combination of site-directed mutagenesis and patch clamp to investigate the binding of ligands to the nAChR and the coupling terween ligand binding and channel opening. Specifically we will: 1) Investigate the contribu...

EB - Genetika a molekulární biologie

  • 1999 - 2002
    • •
  • 5 144 tis. Kč
    • •
  • 2 339 tis. Kč
    • •
  • AV ČR
Project

Cellular and molecular mechanisms of nociception at spinal cord level. (GA309/03/0752)

and single channel properties of glutamate receptors will be studied using patch clamp...

FH - Neurologie, neurochirurgie, neurovědy

  • 2003 - 2005
    • •
  • 2 074 tis. Kč
    • •
  • 2 074 tis. Kč
    • •
  • GA ČR
Project

Phenotypic regulation and functional properties of glutamate receptor channels on spinal cord neurones (GA309/00/1654)

. The patch clamp technique, together with the molecular analysis of the receptor subunit...

FH - Neurologie, neurochirurgie, neurovědy

  • 2000 - 2002
    • •
  • 4 729 tis. Kč
    • •
  • 2 793 tis. Kč
    • •
  • GA ČR
  • 1 - 10 out of 149