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1 201 (0,172s) •

Project

Development of chemical regulators of miRNA and RNAi pathways (GA13-29531S)

Here, we propose to use chemical biology to study miRNA and RNAi pathways. These pathways use small RNAs as sequence-specic guides for silencing gene expression. miRNAs of small molecules inhibiting or stimulating miRNA and RNAi

EB - Genetika a molekulární biologie

  • 2013 - 2018
    • •
  • 8 056 tis. Kč
    • •
  • 8 056 tis. Kč
    • •
  • GA ČR
Project

Establishing the signaling pathway associated with secondary injury, reactive oxygen species and inflammation in spinal cord injury and during its repair. (LTAUSA17120)

To study signalling pathways activated during spinal cord injury, particularly mTOR pathway in cells and in spinal cord tissue. To study inhibition of mTOR pathway using blocators of mTORC1 or mTORC2 complex. To study the e...

FH - Neurologie, neurochirurgie, neurovědy

  • 2017 - 2020
    • •
  • 7 673 tis. Kč
    • •
  • 7 673 tis. Kč
    • •
  • MŠMT
Project

Heme Biosynthesis in Euglenozoa (GA206/08/1423)

necessary for life.However, this pathway is obviously absent in trypanosomas represent a unique model possessing both known pathways to synthesize heme; one is localized in complex chloroplast (5C pathway), the second is a...

EE - Mikrobiologie, virologie

  • 2008 - 2010
    • •
  • 2 255 tis. Kč
    • •
  • 2 255 tis. Kč
    • •
  • GA ČR
Project

Effects of dehydroepiandrosterone (DHEA) on signallin pathways of energy metabolism in human hepatocytes (1P05OC063)

analysis of impacts of hormones DHEA and DHEA-S on signallin pathways regulating metabolism of main energetic substrates in human body...

FE - Ostatní obory vnitřního lékařství

  • 2005 - 2005
    • •
  • 638 tis. Kč
    • •
  • 426 tis. Kč
    • •
  • MŠMT
Project

Dysfunction of the apoptosome pathway in non-small cell lung cancer (NS9715)

The project is aimed at the study of molecular mechanisms underlying apoptosome pathway dysfunction in non-small cell lung carcinoma (NSCLC) cells and tissues, with using the methods of derepression of apoptosome apparatus activation and act...

FD - Onkologie a hematologie

  • 2008 - 2011
    • •
  • 5 508 tis. Kč
    • •
  • 5 508 tis. Kč
    • •
  • MZ
Project

Iron-sulfur cluster biosynthesis in Giardia intestinalis mitosomes and their role in cellular metabolism and antibiotic resistance. (GA23-06888S)

Synthesis of iron-sulfur clusters via the ISC pathway is one of the key role of mitochondria. The pathway supplies these cofactors to the respiratory chain and other-mitochondrial cluster biosynthesis. ISC pathway remained ...

Biochemistry and molecular biology

  • 2023 - 2025
    • •
  • 9 368 tis. Kč
    • •
  • 9 368 tis. Kč
    • •
  • GA ČR
Project

Structural biology of the Wnt/PCP signaling pathway (LUAUS25170)

The non-canonical Wnt pathway, specifically the planar cell polarity (PCP) pathway, plays a key role in physiological processes such as embryonic development, tissue homeostasis, and cell migration. The PCP pathway controls...

Biochemistry and molecular biology

  • 2025 - 2028
    • •
  • 11 980 tis. Kč
    • •
  • 11 980 tis. Kč
    • •
  • MŠMT
Project

The role of the JAK/STAT signalling pathway in cellular senescence (GA204/08/1418)

Cellular senescence is proposed to be a tumorigenesis barrier to slow or inhibit the progression of proneoplastic lesions to neoplasia. In our recent work we found persistent activation of JAK/STAT signaling pathway during drug-induced senes...

CE - Biochemie

  • 2008 - 2012
    • •
  • 6 643 tis. Kč
    • •
  • 6 643 tis. Kč
    • •
  • GA ČR
Project

Removing tumour cells defences Defining and inhibiting the survival pathways exploited by tumour cells that suppress Fas-mediated apoptosis (GA301/00/0563)

how tumoraccomplish this desentization of the intracellular Fas signalling pathway. Molecular survival pathways which might inhibit Fas-mediated signalling in tumor cells include ERK (MAPK) pathway and the mitochondrial ap...

FD - Onkologie a hematologie

  • 2000 - 2002
    • •
  • 1 802 tis. Kč
    • •
  • 1 552 tis. Kč
    • •
  • GA ČR
Project

Molecular mechanisms of non-canonical Wnt signaling in leukemia (GAP301/11/0747)

Wnts, a family of glycoproteins, signal through a variety of signaling pathways of non-canonical Wnt signalling (Wnt/PCP pathway) in context of B-Cell Chronic LymphocyticLeukaemia (CLL). Functional studies of the Wnt/PCP pathway...

FD - Onkologie a hematologie

  • 2011 - 2014
    • •
  • 5 360 tis. Kč
    • •
  • 5 360 tis. Kč
    • •
  • GA ČR
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