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913 (0,099s) •

Project

Novel peptide‐based aggregation inhibitors as potential therapeutics for neurodegenerative diseases (8X25063)

peptides (iv) Assessment of the toxicity and overall effects of selected LEA-based peptides in neural cell lines. (v) Validation of Aβ40 and α-Syn anti-aggregationThe project's overall objective is to identify LEA-based pr...

Biophysics

  • 2025 - 2027
    • •
  • 246 tis. Kč
    • •
  • 246 tis. Kč
    • •
  • MŠMT
Project

Combinatorial approach to myelin and/or beta-sheet breakers. Implication for the therapeutic approaches to Alzheiner's and prion diseases (GA203/02/1379)

peptide aggregates. In these experiment we will use fluorescent and dialysis method.-intercalator peptide library functionalized with 9-amino acridine and to prepare a peptide fragment fromhuman prion protein (HuP...

CC - Organická chemie

  • 2002 - 2004
    • •
  • 1 840 tis. Kč
    • •
  • 1 327 tis. Kč
    • •
  • GA ČR
Project

Self-assembly of amphiphilic peptides with helical character (GA14-12598S)

In living organisms, a wide variety of peptides self-assemble into a range conditions and properties of self-assembly of amphiphilic peptides with prolate shape. The key insight in the self-assembly is rationalization of the depende...

CF - Fyzikální chemie a teoretická chemie

  • 2014 - 2018
    • •
  • 4 460 tis. Kč
    • •
  • 4 460 tis. Kč
    • •
  • GA ČR
Project

Membrane interactions of proteins associated with alzheimer's disease and parkinson's disease implications for diseases' pathologies and therapeutic avenues (LH13259)

disruption by amyloidogenic peptides and their aggregates. This information might shedAberrant misfolding and aggregation of amyloidogenic proteins is implicated for the occurrenceof these incurable diseases are still unkn...

BO - Biofyzika

  • 2013 - 2015
    • •
  • 1 365 tis. Kč
    • •
  • 1 365 tis. Kč
    • •
  • MŠMT
Project

Comparison of effects of amyloid beta peptide 1-40 and 1-42 on hemicholinium-3 sensitive choline carriers and influence of cholesterol (GA305/03/1547)

of amyloidbeta peptides (Abeta) depending on their aggregation. Our earlier experiments to the nonspecific interaction of peptide with membrane lipids occur here.Theaim of the project is to evaluate differences between act...

FH - Neurologie, neurochirurgie, neurovědy

  • 2003 - 2005
    • •
  • 1 404 tis. Kč
    • •
  • 1 404 tis. Kč
    • •
  • GA ČR
Project

Capillary electromigration methods and their application for the separation of proteins and peptides (GV203/96/K128)

and physico-chemsical characterization of peptides along with the development of new proteins, peptide hormones, peptides involved in reproduction functions etc will be focused both on the separation of protein aggrega...

CE - Biochemie

  • 1996 - 2000
    • •
  • 5 646 tis. Kč
    • •
  • 5 646 tis. Kč
    • •
  • GA ČR
Project

Evaluation of the binding between cerebrosterol and amyloid beta peptide 1-40 (GA305/09/0457)

indicated the decreased actions of nonaggregated and aggregated peptides when racemic 24, it is suggested that amyloid beta peptides play a key role in the pathogenesis of disease. Toxicity of peptides is probably...

CE - Biochemie

  • 2009 - 2011
    • •
  • 2 238 tis. Kč
    • •
  • 2 238 tis. Kč
    • •
  • GA ČR
Project

Development of New Fluorescence Methods for the Characterization of Pores Formed by Antimicrobial Peptides (GAP208/10/1090)

Antimicrobial peptides, AMPs, disrupt biological membranes with the possible consequence of cell death. They have raised much interest as possible alternatives to conventional antibiotics. One main mechanism for the function of AMPs is the f...

CF - Fyzikální chemie a teoretická chemie

  • 2010 - 2012
    • •
  • 2 162 tis. Kč
    • •
  • 2 162 tis. Kč
    • •
  • GA ČR
Project

Non-natural inhibitors of physiologically important protein interaction systems based on synthetic combinatorial libraries (GA203/97/1025)

peptide and non-peptide structures. They will be used for design and synthesis of non, inhibitors of platelet aggregation and fibrin(ogen) interactions, and antagonists......

CE - Biochemie

  • 1997 - 1999
    • •
  • 2 711 tis. Kč
    • •
  • 1 776 tis. Kč
    • •
  • GA ČR
Project

Expanding the Optical Activity Method to the Realm of Biomolecules (GAP208/11/0105)

. The methods will be applied to prion-derived peptide segments, nanotube-DNA aggregates...

CF - Fyzikální chemie a teoretická chemie

  • 2011 - 2015
    • •
  • 15 766 tis. Kč
    • •
  • 15 766 tis. Kč
    • •
  • GA ČR
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